hCD154 Recombinant Protein

Human CD154 (CD40 Ligand) is a member of the tumor necrosis factor (TNF) family and is expressed on the surface of activated T cells. It can undergo proteolytic cleavage into a 19kD immunologically active soluble form. Interaction of CD154 and CD40 is essential for isotype switching in B cells. Known genetic defects that alter this interaction lead to impaired immune system function (1). Increased levels of CD154 has been associated with autoimmune disorders including SLE, CLL and eosinophilic fasciitis (5,9,10,11). CD154 has been reported to be expressed on vascular endothelial cells, smooth muscle cells, macrophages and activated platelets indicating a role for the CD40-CD154 immunoregulatory signaling in arthrosclerosis and cardiovascular disorders (7,12,13).

1)D. Gray, et al, (1994) Seminars in Immunol 6: 303-310. 2) A.C. Grammer, et al, (1995) J Immunol 154: 4996-5010. 3) F. Pietravalle, et al, (1996) J Biol Chemistry 271: 5965-5967. 4) R.J. Noelle, (1996) Immunity 4: 415-419. 5) A. Desai-Mehta, et al, (1996) J Clin Invest 97: 2063-2073. 6) I.S. Grewal and R.A. Flavell, (1996) Immunol Today 17: 410-414. 7) F. Mach, et al, (1997) Proc Natl Acad Sci USA 94:1931-1936. 8) A.C. Grammer, et al, (1999) J Immunol 163: 4150-4159. 9) D. Hollenbaugh, (1992) EMBO 11: 4314-4321. 10) R.K. Vakkalanka, et al, (1999) Arthritis Rhem 42:871-81. 11) M. Jinnin, et al.(2003) Ann Rhem Dis 62: 190-191. 12) U. Schonbeck, et al, (2000) PNAS USA 97: 7458-7463. 13) U. Schonbeck, et al, (2001) Circulation 104: 2266-2268. 14) AC Grammer, PF Lipsky, et al (2000) Advances in Immunology 76: 61-178. 15) AC Grammer, PF Lipsky, et al (2004) Arthristis Research and Therapy 6: 28-38. 16). Melter M, D M Briscoe, et al (2000) Blood 96:3801-3808. 17). Takamatsu H, RME Parkhouse, et al. (1999) Immunology 97(2):211-213. 18) Daisuke I, J F Modiano, et al. (2012) Leukemia and Lymphoma 53(7): 1390-1398 19) Brodeur SR, RS Geha, et al. (2003) Immunity 18(6): 837-848 20) KC Bankert, GA Bishop, et al.(2015) J Immunol 194(9): 4319-4327. PMID: 25795759.ID: 21) CR Smulski, S Fournel, et al. (2017) Cell Death and Disease 8(2):e2601. doi: 10.1038/cddis.2017.22. PMID: 28182009

Small volumes of hCD154 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS666938 is a recombinant protein targeting hCD154. Also known as Recombinant hCD154-muCD8 R-PE Conjugate.