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TLR10 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS668030

TLR10 (Toll-Like Receptor10) is an orphan member of the TLR family and is the only pattern-recognition receptor without known ligand specificity and biological function. This protein plays a role in innate immune responses following viral infection. Influenza… More details

$210 / 0.025 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TLR10, Monoclonal Antibody
Full Product Name
TLR10 Monoclonal Antibody
Product Gene Name
anti-TLR10 antibody
Clonality
Monoclonal
Isotype
Mouse IgG2a, Kappa
Clone Number
ABM3C85
Host
Mouse
Species Reactivity
Human
Form/Format
Purified; 25 ug in 50 ul/100 ug in 200 ul PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Purity/Purification
Protein G Chromatography
Preparation and Storage
Store antibody at 4 degree C, stable for 6 months. For long-term storage, store at -20 degree C. Avoid repeated freeze and thaw cycles. Expire 1 year from date of purchase.
OMIM
606270
3D Structure
ModBase 3D Structure for Q9BXR5
Antigen
TLR10
Immunogen
A partial length recombinant TLR10 protein (Amino acid sequence 100-369 ) was used as the immunogen for this antibody.

Product Categories/Family for anti-TLR10 antibody

TLR
Applications Tested/Suitable for anti-TLR10 antibody
Western Blot (WB)
Application Notes for anti-TLR10 antibody
Western blot analysis: 2-4 ug/ml

Western Blot (WB) of anti-TLR10 antibody

Expression analysis of TLR10. Anti- TLR10 antibody (Clone: ABM3C85) was used at 2 µg/ml on human ovary lysate.
Mouse Anti-TLR10 Monoclonal Antibody – Cat# MBS668030

Flow Cytometry (FC/FACS) of anti-TLR10 antibody

Intracellular flow analysis of TLR10 in human PBMC (monocytes) using 2.0 µg/10^6 cells of TLR10 antibody (Clone: ABM3C85). Green represents isotype control; red represents anti-TLR10 antibody. Goat anti-mouse PE conjugate was used as secondary.
Mouse Anti-TLR10 Monoclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS668030

Other Notes

Small volumes of anti-TLR10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TLR10 purchase

MBS668030 is an antibody targeting TLR10. Also known as TLR10 Monoclonal Antibody. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for TLR10. It may not necessarily be applicable to this product.

NCBI GI #
62865621
NCBI GeneID
81793
NCBI Accession #
NP_001017388.1
UniProt Primary Accession #
Q9BXR5
UniProt Secondary Accession #
Q32MI7; Q32MI8; Q5FWG4; Q6UXL3; A8K7L1; B3Y668; D1CS21; D1CS22
UniProt Related Accession #
Q9BXR5
GenBank Nucleotide #
NM_001017388.2
NCBI Official Full Name
toll-like receptor 10 isoform a
NCBI Official Synonym Full Names
toll-like receptor 10
NCBI Official Symbol
TLR10
NCBI Official Synonym Symbols
CD290
UniProt Protein Name
Toll-like receptor 10
UniProt Synonym Protein Names
CD_antigen: CD290
Protein Family
Toll-like receptor
UniProt Gene Name
TLR10
UniProt Entry Name
TLR10_HUMAN
NCBI Protein Information
toll-like receptor 10

NCBI Summary for TLR10

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2010]
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UniProt Comments for TLR10

TLR10: Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Belongs to the Toll-like receptor family.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4p14

Cellular Component: membrane; plasma membrane; integral to membrane

Molecular Function: transmembrane receptor activity

Biological Process: toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; regulation of cytokine secretion; toll-like receptor signaling pathway; innate immune response; immune response; inflammatory response; positive regulation of inflammatory response; toll-like receptor 10 signaling pathway
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Research Articles on TLR10

1. TLR10 is a modulatory pattern-recognition receptor with mainly inhibitory properties

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-TLR10 antibody

 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With The TLR Signaling Cascade Pathway antibodies  Diseases Associated With The TLR Signaling Cascade Pathway Diagram
 Diseases Of Immune System Pathway antibodies  Diseases Of Immune System Pathway Diagram
 IRAK4 Deficiency (TLR5) Pathway antibodies  IRAK4 Deficiency (TLR5) Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 MyD88 Cascade Initiated On Plasma Membrane Pathway antibodies  MyD88 Cascade Initiated On Plasma Membrane Pathway Diagram
 Toll Like Receptor 10 (TLR10) Cascade Pathway antibodies  Toll Like Receptor 10 (TLR10) Cascade Pathway Diagram
 Toll Like Receptor 5 (TLR5) Cascade Pathway antibodies  Toll Like Receptor 5 (TLR5) Cascade Pathway Diagram
 Toll-Like Receptors Cascades Pathway antibodies  Toll-Like Receptors Cascades Pathway Diagram

Diseases associated with anti-TLR10 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >38 publications with TLR10 and Inflammation
 Lung Diseases Antibodies  >11 publications with TLR10 and Lung Diseases
 Asthma Antibodies  >11 publications with TLR10 and Asthma
 Hypersensitivity Antibodies  >9 publications with TLR10 and Hypersensitivity
 Necrosis Antibodies  >8 publications with TLR10 and Necrosis
 Respiratory Hypersensitivity Antibodies  >7 publications with TLR10 and Respiratory Hypersensitivity
 Carcinoma Antibodies  >5 publications with TLR10 and Carcinoma
 Cardiovascular Diseases Antibodies  >5 publications with TLR10 and Cardiovascular Diseases
 Kidney Diseases Antibodies  >4 publications with TLR10 and Kidney Diseases
 Death Antibodies  >3 publications with TLR10 and Death

Organs/Tissues associated with anti-TLR10 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >50 publications with TLR10 and Blood
 Lung Antibodies  >8 publications with TLR10 and Lung
 Spleen Antibodies  >7 publications with TLR10 and Spleen
 Bone Antibodies  >5 publications with TLR10 and Bone
 Intestine Antibodies  >5 publications with TLR10 and Intestine
 Lymph Node Antibodies  >5 publications with TLR10 and Lymph Node
 Brain Antibodies  >4 publications with TLR10 and Brain
 Connective Tissue Antibodies  >2 publications with TLR10 and Connective Tissue
 Trachea Antibodies  >1 publications with TLR10 and Trachea
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