Nucleophosmin (NPM1) Antibody – Rabbit Polyclonal

NPM1: a nucleolar protein associated with nucleolar ribonucleoprotein structures and that binds single-stranded nucleic acids. Is a major component of template activating factor (TAF)-III. It plays a role in controlling centrosome duplication, and may function in the assembly and/or transport of the ribosome. Two alternatively spliced isoforms have been described.

Protein type: Nucleolus; Translation; Oncoprotein; RNA-binding

Cellular Component: centrosome; small ribosomal subunit; granular component; focal adhesion; cell; spindle pole centrosome; cytosol; ribonucleoprotein complex; nucleoplasm; cytoskeleton; membrane; cytoplasm; nucleolus; nuclear speck; intracellular; nucleus; large ribosomal subunit

Molecular Function: protein homodimerization activity; protein kinase inhibitor activity; histone binding; RNA binding; transcription coactivator activity; unfolded protein binding; protein kinase binding; ribosomal large subunit binding; NF-kappaB binding; rRNA binding; protein binding; phosphatidylinositol-3,4,5-triphosphate binding; enzyme binding; DNA binding; nucleic acid binding; protein heterodimerization activity; Tat protein binding; ribosomal small subunit binding

Biological Process: positive regulation of catalytic activity; positive regulation of DNA metabolic process; regulation of centriole replication; positive regulation of translation; regulation of cell cycle; centrosome cycle; nucleocytoplasmic transport; ribosomal large subunit biogenesis and assembly; ribosomal large subunit export from nucleus; regulation of DNA damage response, signal transduction by p53 class mediator; activation of NF-kappaB transcription factor; negative regulation of cell proliferation; protein localization; regulation of neuron apoptosis; positive regulation of cell proliferation; response to stress; cell growth; protein homooligomerization; ribosomal small subunit export from nucleus; protein destabilization; cell aging; positive regulation of cellular biosynthetic process; DNA repair; protein oligomerization; nucleosome assembly; ribosomal small subunit biogenesis and assembly; rRNA export from nucleus; regulation of endodeoxyribonuclease activity; negative regulation of nuclear mRNA splicing, via spliceosome; positive regulation of protein kinase activity; cell volume homeostasis; positive regulation of DNA replication; negative regulation of apoptosis