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IFIT2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS668147

MBS668147 is an antibody targeting IFIT2. Also known as IFIT2 Polyclonal Antibody. Reactive in Human (Predicted Reactivity: Mouse. Host: Rabbit. More details

$200 / 0.025 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IFIT2, Polyclonal Antibody
Full Product Name
IFIT2 Polyclonal Antibody
Product Gene Name
anti-IFIT2 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human (Predicted Reactivity: Mouse
Form/Format
Purified (Liquid)
Concentration
0.5mg/ml, 200µl (lot specific)
Preparation and Storage
Store antibody at 4 degree C, stable for 6 months. For long-term storage, store at -20 degree C. Avoid repeated freeze and thaw cycles. Expire 1 year from date of purchase.
Molecular Weight
54,632 Da
OMIM
147040
3D Structure
ModBase 3D Structure for P09913
Antigen
IFIT2
Immunogen
A partial recombinant IFIT2 protein (amino acids 150-370) was used as the immunogen for this antibody.

Product Categories/Family for anti-IFIT2 antibody

Immunology
Applications Tested/Suitable for anti-IFIT2 antibody
Western Blot (WB)
Application Notes for anti-IFIT2 antibody
Western Blot: 2-4 µg/ml

Western Blot (WB) of anti-IFIT2 antibody

Expression analysis of IFIT2. Anti-IFIT2 antibody (11-4059) was used at 4 µg/ml on Hela lysate.
Rabbit Anti-IFIT2 Polyclonal Antibody – Cat# MBS668147

Other Notes

Small volumes of anti-IFIT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IFIT2. It may not necessarily be applicable to this product.

NCBI GI #
153082755
NCBI GeneID
3433
NCBI Accession #
NP_001538.4
UniProt Primary Accession #
P09913
UniProt Secondary Accession #
Q5T767
UniProt Related Accession #
P09913
GenBank Nucleotide #
NM_001547.4
NCBI Official Full Name
interferon-induced protein with tetratricopeptide repeats 2
NCBI Official Synonym Full Names
interferon-induced protein with tetratricopeptide repeats 2
NCBI Official Symbol
IFIT2
NCBI Official Synonym Symbols
P54; G10P2; IFI54; ISG54; cig42; IFI-54; IFIT-2; GARG-39; IFI-54K; ISG-54K; ISG-54 K
UniProt Protein Name
Interferon-induced protein with tetratricopeptide repeats 2
UniProt Synonym Protein Names
ISG-54 K; Interferon-induced 54 kDa protein; IFI-54K; P54
Protein Family
Interferon-induced protein with tetratricopeptide repeats
UniProt Gene Name
IFIT2
UniProt Synonym Gene Names
CIG-42; G10P2; IFI54; ISG54; IFIT-2; IFI-54K; P54
UniProt Entry Name
IFIT2_HUMAN
NCBI Protein Information
interferon-induced protein with tetratricopeptide repeats 2; Interferon, alpha-inducible protein (MW 54kD); interferon-induced 54 kDa protein; interferon-induced protein 54

UniProt Comments for IFIT2

IFIT2: IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O- methylation (cap snatching mechanism). Can promote apoptosis. Belongs to the IFIT family.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 10q23.31

Cellular Component: endoplasmic reticulum; cytoplasm; cytosol

Molecular Function: protein binding

Biological Process: apoptotic mitochondrial changes; positive regulation of apoptosis; cytokine and chemokine mediated signaling pathway; response to virus; negative regulation of protein binding; defense response to virus
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Research Articles on IFIT2

1. Data shows that IFIT2 expression is downregulated in adenocarcinoma of gastric esophageal junction cells; its ectopic expression leads to cell apoptosis, suggesting its role as a tumor suppressor.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IFIT2 antibody

 Reference Product  PubMed Publications
 IFIT3 antibody  >28 publications with IFIT2 and IFIT3
 ISG15 antibody  >11 publications with IFIT2 and ISG15
 MX1 antibody  >9 publications with IFIT2 and MX1
 IRF7 antibody  >5 publications with IFIT2 and IRF7
 MX2 antibody  >5 publications with IFIT2 and MX2
 IRF1 antibody  >5 publications with IFIT2 and IRF1
 IRF3 antibody  >5 publications with IFIT2 and IRF3
 STAT2 antibody  >4 publications with IFIT2 and STAT2
 ISG20 antibody  >4 publications with IFIT2 and ISG20
 OASL antibody  >3 publications with IFIT2 and OASL

Pathways associated with anti-IFIT2 antibody

 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interferon Signaling Pathway antibodies  Interferon Signaling Pathway Diagram
 Interferon Alpha/beta Signaling Pathway antibodies  Interferon Alpha/beta Signaling Pathway Diagram
 Type II Interferon Signaling (IFNG) Pathway antibodies  Type II Interferon Signaling (IFNG) Pathway Diagram

Diseases associated with anti-IFIT2 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >10 publications with IFIT2 and Inflammation
 Nervous System Diseases Antibodies  >8 publications with IFIT2 and Nervous System Diseases
 Immune System Diseases Antibodies  >5 publications with IFIT2 and Immune System Diseases
 Skin Diseases Antibodies  >4 publications with IFIT2 and Skin Diseases
 Fever Antibodies  >3 publications with IFIT2 and Fever
 Cell Transformation, Neoplastic Antibodies  >2 publications with IFIT2 and Cell Transformation, Neoplastic
 Disease Models, Animal Antibodies  >2 publications with IFIT2 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >2 publications with IFIT2 and Cardiovascular Diseases
 Necrosis Antibodies  >2 publications with IFIT2 and Necrosis
 Influenza, Human Antibodies  >2 publications with IFIT2 and Influenza, Human

Organs/Tissues associated with anti-IFIT2 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >7 publications with IFIT2 and Lung
 Brain Antibodies  >7 publications with IFIT2 and Brain
 Blood Antibodies  >6 publications with IFIT2 and Blood
 Liver Antibodies  >4 publications with IFIT2 and Liver
 Kidney Antibodies  >4 publications with IFIT2 and Kidney
 Skin Antibodies  >4 publications with IFIT2 and Skin
 Bone Antibodies  >3 publications with IFIT2 and Bone
 Bone Marrow Antibodies  >3 publications with IFIT2 and Bone Marrow
 Mouth Antibodies  >2 publications with IFIT2 and Mouth
 Testis Antibodies  >2 publications with IFIT2 and Testis
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