CD4 Antibody – Rat Monoclonal

CD4: Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts. Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane, is part of P4HB/PDI- CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins. Interacts with PTK2/FAK1; this interaction requires the presence of HIV-1 gp120.

Protein type: Cell surface; Membrane protein, integral

Cellular Component: cell surface; endoplasmic reticulum lumen; endoplasmic reticulum membrane; external side of plasma membrane; integral to membrane; lipid raft; membrane; plasma membrane

Molecular Function: coreceptor activity; enzyme binding; glycoprotein binding; immunoglobulin binding; MHC class II protein binding; protein binding; protein homodimerization activity; protein kinase binding; zinc ion binding

Biological Process: adaptive immune response; cell adhesion; cell surface receptor linked signal transduction; cytokine production; defense response to Gram-negative bacterium; immune response; immune system process; induction by virus of cell-cell fusion in host; maintenance of cellular protein localization; positive regulation of calcium-mediated signaling; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein kinase activity; positive regulation of T cell activation; positive regulation of T cell proliferation; regulation of T cell activation; T cell activation; T cell differentiation; T cell selection