• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

STRAP Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS668264

MBS668264 is an antibody targeting STRAP. Reactive in Human. Host: Rabbit. More details

$200 / 0.025 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
STRAP, Polyclonal Antibody
Full Product Name
STRAP
Product Gene Name
anti-STRAP antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Purified
Purity/Purification
Protein A purification
Concentration
0.5 ug/ml (lot specific)
Preparation and Storage
Store the antibody at 4 degree C, stable for 6 months. For long-term storage, store at -20 degree C. Avoid repeated freeze and thaw cycles.
Molecular Weight
39,778 Da
OMIM
605986
3D Structure
ModBase 3D Structure for Q9Y3F4
Immunogen
A partial length recombinant STRAP protein (amino acids 100-330) was used as the immunogen for this antibody.
Buffer
PBS containing 0.05% BSA and 0.05% sodium azide.
Target Modification
No
Produced from Ascites
No
Applications Tested/Suitable for anti-STRAP antibody
Western Blot (WB)

Western Blot (WB) of anti-STRAP antibody

Expression analysis of STRAP. Anti-STRAP antibody (11-8036) was used at 1 ug/ml on (1) Hela, (2) Jurkat and (3) HCT-116 lysates.
Rabbit Anti-STRAP Polyclonal Antibody – Cat# MBS668264

Other Notes

Small volumes of anti-STRAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for STRAP. It may not necessarily be applicable to this product.

NCBI GI #
148727341
NCBI GeneID
11171
NCBI Accession #
NP_009109.3
UniProt Primary Accession #
Q9Y3F4
UniProt Secondary Accession #
Q5TZT4; Q9NTK0; Q9UQC8; B2R5S5; B4DNJ6
UniProt Related Accession #
Q9Y3F4
GenBank Nucleotide #
NM_007178.3
NCBI Official Full Name
serine-threonine kinase receptor-associated protein
NCBI Official Synonym Full Names
serine/threonine kinase receptor associated protein
NCBI Official Symbol
STRAP
NCBI Official Synonym Symbols
MAWD; PT-WD; UNRIP
UniProt Protein Name
Serine-threonine kinase receptor-associated protein
UniProt Synonym Protein Names
MAP activator with WD repeats; UNR-interacting protein; WD-40 repeat protein PT-WD
Protein Family
Serine-threonine kinase receptor-associated protein
UniProt Gene Name
STRAP
UniProt Synonym Gene Names
MAWD; UNRIP
UniProt Entry Name
STRAP_HUMAN
NCBI Protein Information
serine-threonine kinase receptor-associated protein

UniProt Comments for STRAP

STRAP: The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. STRAP may play a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein. Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Binds directly to GEMIN6 and GEMIN7. Associates with the complex in the cytoplasm but not in the nucleus. Also interacts with CSDE1/UNR and MAWBP. Interacts with PDPK1. Belongs to the WD repeat STRAP family.

Protein type: RNA splicing; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 12p12.3

Cellular Component: cytoplasm; cytosol; nucleus; SMN complex

Molecular Function: protein binding; receptor binding

Biological Process: maintenance of gastrointestinal epithelium; negative regulation of epithelial cell proliferation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; spliceosomal snRNP biogenesis
Show more

Research Articles on STRAP

1. STRAP inhibits the transactivation function of Sp1 either by directly blocking its DNA binding domain or destabilizing Sp1 protein through ubiquitin-proteasome pathway in cell cycle G1 phase.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-STRAP antibody

 Reference Product  PubMed Publications
 SMAD7 antibody  >11 publications with STRAP and SMAD7
 GEMIN2 antibody  >6 publications with STRAP and GEMIN2
 TGFB1 antibody  >4 publications with STRAP and TGFB1
 GEMIN7 antibody  >4 publications with STRAP and GEMIN7
 GEMIN6 antibody  >3 publications with STRAP and GEMIN6
 PDPK1 antibody  >2 publications with STRAP and PDPK1
 SMN1 antibody  >1 publications with STRAP and SMN1

Pathways associated with anti-STRAP antibody

 Products by Pathway  Pathway Diagram
 Downregulation Of TGF-beta Receptor Signaling Pathway antibodies  Downregulation Of TGF-beta Receptor Signaling Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By TGF-beta Receptor Complex Pathway antibodies  Signaling By TGF-beta Receptor Complex Pathway Diagram
 Survival Motor Neuron (SMN) Complex Pathway antibodies  Survival Motor Neuron (SMN) Complex Pathway Diagram
 Survival Motor Neuron (SMN) Complex Pathway antibodies  Survival Motor Neuron (SMN) Complex Pathway Diagram
 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram
 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram
 TGF-beta Receptor Signaling Activates SMADs Pathway antibodies  TGF-beta Receptor Signaling Activates SMADs Pathway Diagram

Diseases associated with anti-STRAP antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >62 publications with STRAP and Carcinoma
 Cardiovascular Diseases Antibodies  >40 publications with STRAP and Cardiovascular Diseases
 Necrosis Antibodies  >22 publications with STRAP and Necrosis
 Fibrosis Antibodies  >22 publications with STRAP and Fibrosis
 Heart Diseases Antibodies  >21 publications with STRAP and Heart Diseases
 Adenocarcinoma Antibodies  >19 publications with STRAP and Adenocarcinoma
 Inflammation Antibodies  >18 publications with STRAP and Inflammation
 Hypertrophy Antibodies  >11 publications with STRAP and Hypertrophy
 Breast Neoplasms Antibodies  >11 publications with STRAP and Breast Neoplasms
 Mental Disorders Antibodies  >10 publications with STRAP and Mental Disorders

Organs/Tissues associated with anti-STRAP antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >405 publications with STRAP and Muscle
 Bone Antibodies  >164 publications with STRAP and Bone
 Thyroid Antibodies  >115 publications with STRAP and Thyroid
 Skin Antibodies  >103 publications with STRAP and Skin
 Nerve Antibodies  >93 publications with STRAP and Nerve
 Blood Antibodies  >91 publications with STRAP and Blood
 Larynx Antibodies  >83 publications with STRAP and Larynx
 Vascular Antibodies  >68 publications with STRAP and Vascular
 Heart Antibodies  >60 publications with STRAP and Heart
 Trachea Antibodies  >54 publications with STRAP and Trachea
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000