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ASC2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS668515

ASC2/POP1 is a PAAD domain only protein originally identified in a bioinformatics screen aimed at understanding molecular apoptosis mechanisms.Human ASC2/POP1 is an 89 amino acid protein and migrates at ~10-12 kDa on SDS-PAGE gels. ASC2/POP1 has high amino… More details

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Product Overview

Online Datasheet in PDF
Product Name
ASC2, Polyclonal Antibody
Full Product Name
Polyclonal Antibody to ASC2 (ASC-2/POP)
Product Gene Name
anti-ASC2 antibody
Product Synonym Names
PYDC1; ASC2; ASCI; POP1; PYC1; PAAD-only protein 1; Pyrin-only protein 1; cPOP1; cellular POP1; Antibody to ASC2 (ASC-2/POP); Anti-ASC2 (ASC-2/POP) Antibody; ASC2 (ASC-2/POP) Antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Gerbil, Human, Mouse, Rat
Form/Format
50 ul sera
Purity/Purification
Serum
Preparation and Storage
Store the antibody at 4 degree C, stable for 6 months.
For long-term storage, store at -20 degree C.
Avoid repeated freeze and thaw cycles.
Molecular Weight
10,107 Da
OMIM
AF454669 mRNA
3D Structure
ModBase 3D Structure for Q8WXC3
Immunogen Information
A full-length recombinant protein of ASC2 (ASC-2/POP) was used as the immunogen for this antibody
Antigen
ASC2 (ASC-2/POP)

Product Categories/Family for anti-ASC2 antibody

Antibodies; Apoptosis
Applications Tested/Suitable for anti-ASC2 antibody
Western Blot (WB), Immunohistochemistry (IHC) Formalin/Paraffin, Immunoprecipitation (IP)
Application Notes for anti-ASC2 antibody
WB: 1: 1000-1: 2000
IHC (paraffin): 1: 1000-1: 5000
IP: 1: 50-1: 200

Western Blot (WB) of anti-ASC2 antibody

Fig: 1 Western blot analysis of ASC2/POP1 using at 1: 2000. HEK-293 cells were transiently transfected with plasmids encoding ASC2, POP1 or a negative control plasmid. ASC2 and POP1 were detected at the expected 12 kDa molecular weight.
Rabbit Anti-ASC2 Polyclonal Antibody – Cat# MBS668515

Immunohistochemistry (IHC) of anti-ASC2 antibody

Fig: 2 Immunhistochemical analysis of ASC2/POP1 expression in mouse using at 1: 2000. A, prostate tissue from a male mouse prostatitis. B, kidney from a mouse with pyelonephritis. A1 and B1, high magnification of A and B, respectively. ASC2/POP1 staining is seen in the granulocytes.
Rabbit Anti-ASC2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS668515

Immunohistochemistry (IHC) of anti-ASC2 antibody

Fig: 3 Immunhistochemical analysis of ASC2/POP1 expression in mouse spleen using at 1: 2000. A and A1, spleen at low and high magnification, respectively.  ASC2/POP1 staining is seen in the granulocytes, whereas the lymph and megakaryocytes are negative. 
Rabbit Anti-ASC2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS668515

Other Notes

Small volumes of anti-ASC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ASC2 purchase

MBS668515 is an antibody targeting ASC2. Also known as Polyclonal Antibody to ASC2 (ASC-2/POP). Reactive in Gerbil, Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ASC2. It may not necessarily be applicable to this product.

NCBI GI #
74730989
NCBI GeneID
260434
NCBI Accession #
Q8WXC3.1
UniProt Primary Accession #
Q8WXC3
UniProt Secondary Accession #
Q8NFP8; B2R8L4
UniProt Related Accession #
Q8WXC3
NCBI Official Full Name
Pyrin domain-containing protein 1
NCBI Official Synonym Full Names
pyrin domain containing 1
NCBI Official Symbol
PYDC1
NCBI Official Synonym Symbols
ASC2; POP1; PYC1; cPOP1
UniProt Protein Name
Pyrin domain-containing protein 1
UniProt Synonym Protein Names
PAAD-only protein 1
UniProt Gene Name
PYDC1
UniProt Synonym Gene Names
cPOP1
NCBI Protein Information
pyrin domain-containing protein 1

UniProt Comments for ASC2

PYDC1: Associates with apoptosis-associated specklike protein containing a CARD domain (ASC) and modulates its ability to collaborate with pyrin and cryopyrin in NF-kappa-B and pro- caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: cytosol; IkappaB kinase complex; nucleus

Molecular Function: protein binding

Biological Process: inhibition of NF-kappaB transcription factor; innate immune response; negative regulation of interleukin-1 beta secretion; negative regulation of protein kinase activity; positive regulation of interleukin-1 beta secretion; tumor necrosis factor-mediated signaling pathway
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Research Articles on ASC2

1. Changes in the tertiary structure of mutated pyrin B30.2 domain interrupting the formation of the pyrin-caspase-1 complex are related to the manifestations of Mediterranean familial fever.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ASC2 antibody

 Products by Pathway  Pathway Diagram
 NOD-like Receptor Signaling Pathway antibodies  NOD-like Receptor Signaling Pathway Diagram
 NOD-like Receptor Signaling Pathway antibodies  NOD-like Receptor Signaling Pathway Diagram

Diseases associated with anti-ASC2 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1 publications with ASC2 and Inflammation
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