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BAX Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS668531

The Bcl-2 families of apoptosis-related genes plays central roles in regulating apoptotic pathways. Regulation of cell death through apoptosis is critical for the maintenance of homeostasis, defense against infectious agents, and normal development. Bcl-2… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Bax, Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Bax
Product Gene Name
anti-BAX antibody
Product Synonym Names
BAX; BCL2L4; Bcl-2-like protein 4; Antibody to Bax; Anti-Bax Antibody; Bax Antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Dog, Rat, Mouse
Form/Format
50 ul sera
Purity/Purification
Serum
Preparation and Storage
Store the antibody at 4 degree C, stable for 6 months.
For long-term storage, store at -20 degree C.
Avoid repeated freeze and thaw cycles.
Molecular Weight
19,718 Da
OMIM
L22473 mRNA
3D Structure
ModBase 3D Structure for Q07812
Immunogen Information
A full length recombinant protein of mouse Bax was used as immunogen for this antibody
Antigen
Bax

Product Categories/Family for anti-BAX antibody

Antibodies; Apoptosis
Applications Tested/Suitable for anti-BAX antibody
Immunoprecipitation (IP), Immunohistochemistry (IHC) Formalin/Paraffin, Western Blot (WB)
Application Notes for anti-BAX antibody
WB: 1: 1000-1: 2000
IHC (paraffin): 1: 1000-1: 5000
IP: 1: 50-1: 200

Western Blot (WB) of anti-BAX antibody

Fig: 1 Western blot analysis of full-length recombinant mouse Bax using at 1: 2000.
Rabbit Anti-BAX Polyclonal Antibody – Cat# MBS668531

Immunohistochemistry (IHC) of anti-BAX antibody

Fig: 2 Formalin-fixed paraffin embedded section of dog ischemic brain cortex stained for Bax expression using at 1: 2000. At 2 hr post ischemia, Bax staining was seen in the dying neuron that had morphological features of apoptosis.  In contrast, mophologically normal appearing neurons lacked Bax staining (arrowheads). Hematoxylin-eosin counterstain.
Rabbit Anti-BAX Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS668531

Other Notes

Small volumes of anti-BAX antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BAX purchase

MBS668531 is an antibody targeting BAX. Also known as Polyclonal Antibody to Bax. Reactive in Dog, Rat, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for BAX. It may not necessarily be applicable to this product.

NCBI GI #
728945
NCBI GeneID
581
NCBI Accession #
Q07812.1
UniProt Primary Accession #
Q07812
UniProt Secondary Accession #
P55269; Q07814; Q07815; Q8WZ49; Q9NR76; Q9NYG7; Q9UCZ6; Q9UCZ7; Q9UQD6; A8K4W1
UniProt Related Accession #
Q07812
NCBI Official Full Name
Apoptosis regulator BAX
NCBI Official Synonym Full Names
BCL2 associated X, apoptosis regulator
NCBI Official Symbol
BAX
NCBI Official Synonym Symbols
BCL2L4
UniProt Protein Name
Apoptosis regulator BAX
UniProt Synonym Protein Names
Bcl-2-like protein 4; Bcl2-L-4
Protein Family
Apoptosis regulator
UniProt Gene Name
BAX
UniProt Synonym Gene Names
BCL2L4; Bcl2-L-4
NCBI Protein Information
apoptosis regulator BAX

NCBI Summary for BAX

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for BAX

Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
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Research Articles on BAX

1. Low BAX/BCL2 mRNA is associated with laryngeal squamous cell carcinoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-BAX antibody

 Products by Pathway  Pathway Diagram
 Activation, Translocation And Oligomerization Of BAX Pathway antibodies  Activation, Translocation And Oligomerization Of BAX Pathway Diagram
 AhR Pathway antibodies  AhR Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram

Diseases associated with anti-BAX antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >7926 publications with BAX and Neoplasms
 Necrosis Antibodies  >1918 publications with BAX and Necrosis
 Heart Diseases Antibodies  >1787 publications with BAX and Heart Diseases
 Nervous System Diseases Antibodies  >1767 publications with BAX and Nervous System Diseases
 Ischemia Antibodies  >1438 publications with BAX and Ischemia
 Brain Diseases Antibodies  >1319 publications with BAX and Brain Diseases
 Inflammation Antibodies  >944 publications with BAX and Inflammation
 Breast Neoplasms Antibodies  >911 publications with BAX and Breast Neoplasms
 Liver Diseases Antibodies  >902 publications with BAX and Liver Diseases
 Intestinal Neoplasms Antibodies  >801 publications with BAX and Intestinal Neoplasms

Organs/Tissues associated with anti-BAX antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3027 publications with BAX and Blood
 Brain Antibodies  >2292 publications with BAX and Brain
 Liver Antibodies  >1636 publications with BAX and Liver
 Lung Antibodies  >1243 publications with BAX and Lung
 Bone Antibodies  >745 publications with BAX and Bone
 Nerve Antibodies  >700 publications with BAX and Nerve
 Prostate Antibodies  >687 publications with BAX and Prostate
 Skin Antibodies  >492 publications with BAX and Skin
 Stomach Antibodies  >470 publications with BAX and Stomach
 Intestine Antibodies  >380 publications with BAX and Intestine
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