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DLL1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS668627

DLL1 (Delta-like 1) is a human homolog of the Drosophila Notch ligand Delta that is the ligand for Notch3. It belongs to the family of Notch ligands and Notch signaling is one of the most conserved pathways in the regulation of cell differentiation and cell… More details

$200 / 0.025 mg +1 FREE 8GB USB
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
DLL1, Polyclonal Antibody
Full Product Name
Polyclonal Antibody to DLL1
Product Gene Name
anti-DLL1 antibody
Product Synonym Names
DLL1; UNQ146/PRO172; Drosophila Delta homolog 1; Antibody to DLL1; Anti-DLL1 Antibody; DLL1 Antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Predicted: Mouse
Form/Format
25 ug in 50 ul/100 ug in 200 ul PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Purity/Purification
Purified
Protein A Chromatography
Preparation and Storage
Store the antibody at 4 degree C, stable for 6 months.
For long-term storage, store at -20 degree C.
Avoid repeated freeze and thaw cycles.
Molecular Weight
27,355 Da
OMIM
AF003522 mRNA
3D Structure
ModBase 3D Structure for O00548
Immunogen Information
A partial length recombinant DLL1 protein (amino acids 506-714) was used as the immunogen for this antibody.
Antigen
DLL1

Product Categories/Family for anti-DLL1 antibody

Antibodies; Development and Differentiation
Applications Tested/Suitable for anti-DLL1 antibody
Western Blot (WB)
Application Notes for anti-DLL1 antibody
WB: 1-2 ug/ml

Testing Data of anti-DLL1 antibody

Fig-1: Expression analysis of DLL1. Anti-DLL1 antibody (11-10034) was used at 1 ug/ml on h Heart lysate.
Rabbit Anti-DLL1 Polyclonal Antibody – Cat# MBS668627

Other Notes

Small volumes of anti-DLL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DLL1 purchase

MBS668627 is an antibody targeting DLL1. Also known as Polyclonal Antibody to DLL1. Reactive in Human
Predicted: Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DLL1. It may not necessarily be applicable to this product.

NCBI GI #
118582508
NCBI GeneID
28514
NCBI Accession #
O00548.2
UniProt Primary Accession #
O00548
UniProt Secondary Accession #
Q9NU41; Q9UJV2; B2RAK7; B5M0B3
UniProt Related Accession #
O00548
NCBI Official Full Name
Delta-like protein 1
NCBI Official Synonym Full Names
delta like canonical Notch ligand 1
NCBI Official Symbol
DLL1
NCBI Official Synonym Symbols
DL1; Delta; DELTA1
UniProt Protein Name
Delta-like protein 1
UniProt Synonym Protein Names
Drosophila Delta homolog 1; Delta1; H-Delta-1
Protein Family
Delta-like protein
UniProt Gene Name
DLL1
UniProt Synonym Gene Names
Delta1; H-Delta-1
NCBI Protein Information
delta-like protein 1

NCBI Summary for DLL1

DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication. [provided by RefSeq, Jul 2008]

UniProt Comments for DLL1

DLL1: Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor. Interacts with Notch receptors. Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney.

Protein type: Cell development/differentiation; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 6q27

Cellular Component: adherens junction; apical plasma membrane; lipid raft; plasma membrane

Molecular Function: Notch binding; protein binding; Tat protein binding

Biological Process: astrocyte development; cell differentiation; cerebellar molecular layer formation; cerebellar Purkinje cell layer structural organization; determination of left/right symmetry; heart looping; lateral inhibition; marginal zone B cell differentiation; negative regulation of cell differentiation; negative regulation of cell proliferation; negative regulation of epidermal cell differentiation; negative regulation of epithelial cell differentiation; negative regulation of interleukin-10 production; negative regulation of myoblast differentiation; negative regulation of neuron differentiation; neuron fate specification; Notch receptor processing; Notch signaling pathway; organ growth; positive regulation of cell proliferation; positive regulation of endocytosis; positive regulation of Notch signaling pathway; positive regulation of skeletal muscle growth; positive regulation of transcription from RNA polymerase II promoter; proximal/distal pattern formation; regulation of blood pressure; regulation of cell adhesion; regulation of cell division; regulation of growth; regulation of neurogenesis; regulation of skeletal muscle growth; regulation of somitogenesis; retina development in camera-type eye; retina morphogenesis in camera-type eye; skeletal muscle growth; somitogenesis; spinal cord development
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Research Articles on DLL1

1. Mir-34a functions as a regulator by decreasing the expression of NOTCH1 and DLL1. Our study is the first to identify a correlation between mir-34a and its target genes NOTCH1 and DLL1 in endometrial adenocarcinoma

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DLL1 antibody

 Reference Product  PubMed Publications
 NOTCH1 antibody  >103 publications with DLL1 and NOTCH1
 NOTCH2 antibody  >37 publications with DLL1 and NOTCH2
 JAG1 antibody  >33 publications with DLL1 and JAG1
 HES5 antibody  >25 publications with DLL1 and HES5
 JAG2 antibody  >18 publications with DLL1 and JAG2
 NOTCH3 antibody  >16 publications with DLL1 and NOTCH3
 MIB1 antibody  >5 publications with DLL1 and MIB1
 ADAM10 antibody  >3 publications with DLL1 and ADAM10

Pathways associated with anti-DLL1 antibody

 Products by Pathway  Pathway Diagram
 Activated NOTCH1 Transmits Signal To The Nucleus Pathway antibodies  Activated NOTCH1 Transmits Signal To The Nucleus Pathway Diagram
 Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway antibodies  Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 FBXW7 Mutants And NOTCH1 In Cancer Pathway antibodies  FBXW7 Mutants And NOTCH1 In Cancer Pathway Diagram
 NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway antibodies  NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway Diagram
 Neural Crest Differentiation Pathway antibodies  Neural Crest Differentiation Pathway Diagram

Diseases associated with anti-DLL1 antibody

 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >10 publications with DLL1 and Congenital Abnormalities
 Carcinoma Antibodies  >9 publications with DLL1 and Carcinoma
 Disease Models, Animal Antibodies  >9 publications with DLL1 and Disease Models, Animal
 Inflammation Antibodies  >8 publications with DLL1 and Inflammation
 Nervous System Diseases Antibodies  >7 publications with DLL1 and Nervous System Diseases
 Necrosis Antibodies  >5 publications with DLL1 and Necrosis
 Abnormalities, Multiple Antibodies  >5 publications with DLL1 and Abnormalities, Multiple
 Carcinoma, Squamous Cell Antibodies  >4 publications with DLL1 and Carcinoma, Squamous Cell
 Lung Diseases Antibodies  >4 publications with DLL1 and Lung Diseases
 Liver Neoplasms Antibodies  >3 publications with DLL1 and Liver Neoplasms

Organs/Tissues associated with anti-DLL1 antibody

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >39 publications with DLL1 and Embryonic Tissue
 Brain Antibodies  >36 publications with DLL1 and Brain
 Lung Antibodies  >15 publications with DLL1 and Lung
 Intestine Antibodies  >10 publications with DLL1 and Intestine
 Kidney Antibodies  >7 publications with DLL1 and Kidney
 Eye Antibodies  >6 publications with DLL1 and Eye
 Skin Antibodies  >6 publications with DLL1 and Skin
 Ear Antibodies  >5 publications with DLL1 and Ear
 Connective Tissue Antibodies  >4 publications with DLL1 and Connective Tissue
 Lymph Node Antibodies  >3 publications with DLL1 and Lymph Node
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