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DPPA4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS668631

DPPA4 (Developmental pluripotency-associated 4) is a DNA binding SAP domain-containing protein. It is highly expressed in embryonal carcinomas, pluripotent germ cell tumors, and other cancers. It is also mutated in some cancers. DPPA4 overexpression induces… More details

$200 / 0.025 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DPPA4, Polyclonal Antibody
Full Product Name
Polyclonal Antibody to DPPA4
Product Gene Name
anti-DPPA4 antibody
Product Synonym Names
DPPA4; Developmental pluripotency-associated protein 4; Antibody to DPPA4; Anti-DPPA4 Antibody; DPPA4 Antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Predicted: Mouse
Form/Format
25 ug in 50 ul/100 ug in 200 ul PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Purity/Purification
Purified
Protein A Chromatography
Preparation and Storage
Store the antibody at 4 degree C, stable for 6 months.
For long-term storage, store at -20 degree C.
Avoid repeated freeze and thaw cycles.
Molecular Weight
33,541 Da
OMIM
AK001575 mRNA
3D Structure
ModBase 3D Structure for Q7L190
Immunogen Information
A partial length recombinant DPPA4 protein (amino acids 1-206) was used as the immunogen for this antibody.
Antigen
DPPA4

Product Categories/Family for anti-DPPA4 antibody

Antibodies; Stem Cells
Applications Tested/Suitable for anti-DPPA4 antibody
Western Blot (WB)
Application Notes for anti-DPPA4 antibody
WB: 1-2 ug/ml

Testing Data of anti-DPPA4 antibody

Fig-1: Expression analysis DPPA4. Anti-DPPA4 antibody (11-12042) was used at 1 ug/ml on Jurkat lysate.
Rabbit Anti-DPPA4 Polyclonal Antibody – Cat# MBS668631

Other Notes

Small volumes of anti-DPPA4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DPPA4 purchase

MBS668631 is an antibody targeting DPPA4. Also known as Polyclonal Antibody to DPPA4. Reactive in Human
Predicted: Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DPPA4. It may not necessarily be applicable to this product.

NCBI GI #
296434484
NCBI GeneID
55211
NCBI Accession #
Q7L190.2
UniProt Primary Accession #
Q7L190
UniProt Secondary Accession #
Q9H9N5; Q9NVI6; A8K4M7
UniProt Related Accession #
Q7L190
NCBI Official Full Name
Developmental pluripotency-associated protein 4
NCBI Official Synonym Full Names
developmental pluripotency associated 4
NCBI Official Symbol
DPPA4
NCBI Official Synonym Symbols
2410091M23Rik
UniProt Protein Name
Developmental pluripotency-associated protein 4
Protein Family
Developmental pluripotency-associated protein
UniProt Gene Name
DPPA4
NCBI Protein Information
developmental pluripotency-associated protein 4

NCBI Summary for DPPA4

This gene encodes a nuclear factor that is involved in the maintenance of pluripotency in stem cells and essential for embryogenesis. The encoded protein has a scaffold-attachment factor A/B, acinus and PIAS (SAP) domain that binds DNA and is thought to modify chromatin. Mice with a homozygous knockout of the orthologous gene die during late embryonic development or within hours after birth. Knockout embryos are normal in size at embryonic day 18.5 but exhibit skeletal and lung tissue abnormalities. This gene, when mutated, is highly expressed in embryonal carcinomas, pluripotent germ cell tumors, and other cancers and is thought to play an important role in tumor progression. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
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UniProt Comments for DPPA4

DPPA4: May be involved in the maintenance of active epigenetic status of target genes. May inhibit differentiation of embryonic cells into a primitive ectoderm lineage.

Protein type: Cell development/differentiation

Chromosomal Location of Human Ortholog: 3q13.13

Cellular Component: nucleoplasm

Molecular Function: protein binding

Biological Process: somatic stem cell maintenance
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Research Articles on DPPA4

1. knockdown of PCGF1 results in reduced expression of DPPA4 and other subunits of the variant PRC1 complex at both mRNA and protein levels

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DPPA4 antibody

 Reference Product  PubMed Publications
 NANOG antibody  >12 publications with DPPA4 and NANOG
 SOX2 antibody  >12 publications with DPPA4 and SOX2
 TDGF1 antibody  >2 publications with DPPA4 and TDGF1

Pathways associated with anti-DPPA4 antibody

 Products by Pathway  Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 POU5F1 (OCT4), SOX2, NANOG Activate Genes Related To Proliferation Pathway antibodies  POU5F1 (OCT4), SOX2, NANOG Activate Genes Related To Proliferation Pathway Diagram
 Transcriptional Regulation Of Pluripotent Stem Cells Pathway antibodies  Transcriptional Regulation Of Pluripotent Stem Cells Pathway Diagram

Diseases associated with anti-DPPA4 antibody

 Disease Name  Pubmed Publications
 Fetal Death Antibodies  >1 publications with DPPA4 and Fetal Death

Organs/Tissues associated with anti-DPPA4 antibody

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >9 publications with DPPA4 and Embryonic Tissue
 Testis Antibodies  >6 publications with DPPA4 and Testis
 Bone Marrow Antibodies  >3 publications with DPPA4 and Bone Marrow
 Placenta Antibodies  >1 publications with DPPA4 and Placenta
 Ovary Antibodies  >1 publications with DPPA4 and Ovary
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