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NLRP2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS668734

NALP2 (also known as PAN1/PYPAF2) is a member of the NLR (NACHT-LRR) family which includes both NODs and NALPs. Alternative names for the NLR family include CATERPILLER, NOD and NOD-LRR. NLR family members are thought to be intracellular pathogen-recognition… More details

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Product Overview

Online Datasheet in PDF
Product Name
NLRP2/NALP2, Polyclonal Antibody
Full Product Name
Polyclonal Antibody to NLRP2/NALP2 (PAN1)
Product Gene Name
anti-NLRP2 antibody
Product Synonym Names
NLRP2; NALP2; NBS1; PAN1; PYPAF2; Nucleotide-binding site protein 1; PYRIN domain and NACHT domain-containing protein 1; PYRIN-containing APAF1-like protein 2; Antibody to NLRP2/NALP2 (PAN1); Anti-NLRP2/NALP2 (PAN1) Antibody; NLRP2/NALP2 (PAN1) Antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
50 ul sera
Purity/Purification
Serum
Preparation and Storage
Store the antibody at 4 degree C, stable for 6 months.
For long-term storage, store at -20 degree C.
Avoid repeated freeze and thaw cycles.
Molecular Weight
117,883 Da
OMIM
AF298547 mRNA
3D Structure
ModBase 3D Structure for Q9NX02
Immunogen Information
A synthetic peptide of human NALP2 (amino acids 144-159 LGKEVFKGKKPDKDNR) was used as immunogen for this antibody
Antigen
NLRP2/NALP2 (PAN1)

Product Categories/Family for anti-NLRP2 antibody

Antibodies; Apoptosis
Applications Tested/Suitable for anti-NLRP2 antibody
Western Blot (WB), Immunohistochemistry (IHC) Formalin/Paraffin, Immunoprecipitation (IP)
Application Notes for anti-NLRP2 antibody
WB: 1: 1000-1: 2000
IHC (paraffin): 1: 1000-1: 5000
IP: 1: 50-1: 200

Western Blot (WB) of anti-NLRP2 antibody

Fig: 1 Western blot analysis of NALP2 (PAN1/PYPAF2) in differentiated THP-1 cells following IFN (interferon) g stimulation using NALP2 antibody at 1: 2000. TPA-differentiated THP-1 cells were cultured with 1000 units of IFNg for 0-24 hours as described in Bruey et al, 2004. Culturing differentiated THP-1 with IFNg resulted in transient elevations in NALP2 expression which peaked at 4-8 h after INFg treatment.
Rabbit Anti-NLRP2 Polyclonal Antibody – Cat# MBS668734

Other Notes

Small volumes of anti-NLRP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NLRP2 purchase

MBS668734 is an antibody targeting NLRP2. Also known as Polyclonal Antibody to NLRP2/NALP2 (PAN1). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NLRP2. It may not necessarily be applicable to this product.

NCBI GI #
17380148
NCBI GeneID
55655
NCBI Accession #
Q9NX02.1
UniProt Primary Accession #
Q9NX02
UniProt Secondary Accession #
Q53FL5; Q59G09; Q8IXT0; Q9BVN5; Q9H6G6; Q9HAV9; Q9NWK3; B4DZL7; I3L0G4
UniProt Related Accession #
Q9NX02
NCBI Official Full Name
NACHT, LRR and PYD domains-containing protein 2
NCBI Official Synonym Full Names
NLR family pyrin domain containing 2
NCBI Official Symbol
NLRP2
NCBI Official Synonym Symbols
NBS1; PAN1; NALP2; PYPAF2; CLR19.9
UniProt Protein Name
NACHT, LRR and PYD domains-containing protein 2
UniProt Synonym Protein Names
Nucleotide-binding site protein 1; PYRIN domain and NACHT domain-containing protein 1; PYRIN-containing APAF1-like protein 2
Protein Family
NACHT, LRR and PYD domains-containing protein
UniProt Gene Name
NLRP2
UniProt Synonym Gene Names
NALP2; NBS1; PAN1; PYPAF2
NCBI Protein Information
NACHT, LRR and PYD domains-containing protein 2

NCBI Summary for NLRP2

This gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). Members of this gene family are thought to be important regulators of immune responses. This gene product interacts with components of the IkB kinase (IKK) complex, and can regulate both caspase-1 and NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) activity. The pyrin domain is necessary and sufficient for suppression of NF-kB activity. An allelic variant (rs147585490) has been found that is incapable of blocking the transcriptional activity of NF-kB. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
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UniProt Comments for NLRP2

NLRP2: Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases. Belongs to the NLRP family. 4 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 19q13.42

Cellular Component: cytoplasm; Golgi apparatus; intracellular membrane-bound organelle; nuclear chromosome, telomeric region

Molecular Function: protein binding; Pyrin domain binding

Biological Process: positive regulation of caspase activity; positive regulation of interleukin-1 beta secretion
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Research Articles on NLRP2

1. genetic polymorphism is associated with chronic pancreatitis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-NLRP2 antibody

 Products by Pathway  Pathway Diagram
 Nucleotide-binding Oligomerization Domain (NOD) Pathway antibodies  Nucleotide-binding Oligomerization Domain (NOD) Pathway Diagram

Diseases associated with anti-NLRP2 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >17 publications with NLRP2 and Inflammation
 Necrosis Antibodies  >5 publications with NLRP2 and Necrosis
 Diabetes Mellitus Antibodies  >3 publications with NLRP2 and Diabetes Mellitus
 Musculoskeletal Abnormalities Antibodies  >3 publications with NLRP2 and Musculoskeletal Abnormalities
 Genital Diseases, Female Antibodies  >3 publications with NLRP2 and Genital Diseases, Female
 Growth Disorders Antibodies  >2 publications with NLRP2 and Growth Disorders
 Neuromuscular Diseases Antibodies  >1 publications with NLRP2 and Neuromuscular Diseases
 Poisoning Antibodies  >1 publications with NLRP2 and Poisoning
 Fibrosis Antibodies  >1 publications with NLRP2 and Fibrosis
 Male Urogenital Diseases Antibodies  >1 publications with NLRP2 and Male Urogenital Diseases

Organs/Tissues associated with anti-NLRP2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >12 publications with NLRP2 and Blood
 Brain Antibodies  >8 publications with NLRP2 and Brain
 Skin Antibodies  >4 publications with NLRP2 and Skin
 Eye Antibodies  >4 publications with NLRP2 and Eye
 Embryonic Tissue Antibodies  >3 publications with NLRP2 and Embryonic Tissue
 Kidney Antibodies  >2 publications with NLRP2 and Kidney
 Ovary Antibodies  >2 publications with NLRP2 and Ovary
 Lung Antibodies  >2 publications with NLRP2 and Lung
 Heart Antibodies  >1 publications with NLRP2 and Heart
 Pancreas Antibodies  >1 publications with NLRP2 and Pancreas
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