Myosin Heavy Chain 10, Non Muscle (MYH10) ELISA Kit for Mouse

This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-14 (MYO14). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene result in one form of autosomal dominant hearing impairment. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

MYH14: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). High levels of expression are found in small intestine, colon and skeletal muscle. Expression is low in organs composed mainly of smooth muscle, such as aorta, uterus and urinary bladder. No detectable expression is found in thymus, spleen, placenta and lymphocytes. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Motor

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: growth cone; membrane; axon; myosin II complex; cytoplasm; stress fiber; actomyosin

Molecular Function: microfilament motor activity; calmodulin binding; actin filament binding; actin-dependent ATPase activity; ATP binding

Biological Process: skeletal muscle contraction; axon guidance; regulation of cell shape; skeletal muscle development; sensory perception of sound; actin filament-based movement; metabolic process; actomyosin structure organization and biogenesis; ephrin receptor signaling pathway; generation of action potential

Disease: Peripheral Neuropathy, Myopathy, Hoarseness, And Hearing Loss; Deafness, Autosomal Dominant 4a