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PTPN13 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS668759

This antibody recognizes FAP-1, including FAP-1 isoforms; FAP-1 (also known as Fas-associated phosphatase-1, PTPN13, PTP-BAS, hPTPIE, and PTPL1) is a member of the protein tyrosine phosphatase (PTP) family. FAP-1 phosphatase is thought to be important in the… More details

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Product Overview

Online Datasheet in PDF
Product Name
PTPN13/PTPL1, Polyclonal Antibody
Full Product Name
Polyclonal Antibody to PTPN13/PTPL1 (FAP1)
Product Gene Name
anti-PTPN13 antibody
Product Synonym Names
PTPN13; PNP1; PTP1E; PTPL1; Fas-associated protein-tyrosine phosphatase 1; PTP-BAS; PTP-E1; Protein-tyrosine phosphatase 1E; Protein-tyrosine phosphatase PTPL1; Antibody to PTPN13/PTPL1 (FAP1); Anti-PTPN13/PTPL1 (FAP1) Antibody; PTPN13/PTPL1 (FAP1) Antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
50 ul sera
Purity/Purification
Serum
Preparation and Storage
Store the antibody at 4 degree C, stable for 6 months.
For long-term storage, store at -20 degree C.
Avoid repeated freeze and thaw cycles.
Molecular Weight
277,508 Da
OMIM
U12128 mRNA
3D Structure
ModBase 3D Structure for Q12923
Immunogen Information
A recombinant protein of human FAP-1 (amino acids 1279 to 1883) was used as immunogen for this antibody
Antigen
PTPN13/PTPL1 (FAP1)

Product Categories/Family for anti-PTPN13 antibody

Antibodies; Apoptosis
Applications Tested/Suitable for anti-PTPN13 antibody
Immunoprecipitation (IP), Immunohistochemistry (IHC) Formalin/Paraffin, Western Blot (WB)
Application Notes for anti-PTPN13 antibody
WB: 1: 1000-1: 2000
IHC (paraffin): 1: 1000-1: 5000
IP: 1: 50-1: 200

Western Blot (WB) of anti-PTPN13 antibody

Fig: 1 Western blot analysis of FAP-1 using at 1: 2000. In ovarian carcinoma cell lines FAP-1 expression was detected in SK-OV-3 and OVCAR-3, but not in BG-1 or HEY. Human Jurkat T and 293 kidney cell lines were used as negative and positive controls, respectively.
Rabbit Anti-PTPN13 Polyclonal Antibody – Cat# MBS668759

Immunohistochemistry (IHC) of anti-PTPN13 antibody

Fig: 2 Immunohistochemisty of FAP-1 in formalin-fixed, paraffin embedded ovarian carcinoma cores from a tissue microarray using at 1: 2000. A-D, samples are from four different patients. A1-D1 are high magnification images from A-D, respectively. Hematoxylin-eosin counterstain.
Rabbit Anti-PTPN13 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS668759

Immunohistochemistry (IHC) of anti-PTPN13 antibody

Fig: 3 Immunocytochemical analysis of FAP-1 in cell lines using at 1: 2000. In ovarian carcinoma cell lines FAP-1 expression was detected in SK-OV-3 and OVCAR-3, but not in BG-1 or HEY. Human 293 kidney and Jurkat T cell lines were used as positive and negative controls, respectively. The staining data correlates with the western blot data (figure to the left).
Rabbit Anti-PTPN13 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS668759

Other Notes

Small volumes of anti-PTPN13 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PTPN13 purchase

MBS668759 is an antibody targeting PTPN13. Also known as Polyclonal Antibody to PTPN13/PTPL1 (FAP1). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PTPN13. It may not necessarily be applicable to this product.

NCBI GI #
12643716
NCBI GeneID
5783
NCBI Accession #
Q12923.2
UniProt Primary Accession #
Q12923
UniProt Secondary Accession #
Q15159; Q15263; Q15264; Q15265; Q15674; Q16826; Q8IWH7; Q9NYN9; Q9UDA8; B2RTR0
UniProt Related Accession #
Q12923
NCBI Official Full Name
Tyrosine-protein phosphatase non-receptor type 13
NCBI Official Synonym Full Names
protein tyrosine phosphatase, non-receptor type 13
NCBI Official Symbol
PTPN13
NCBI Official Synonym Symbols
PNP1; FAP-1; PTP1E; PTPL1; PTPLE; PTP-BL; hPTP1E; PTP-BAS
UniProt Protein Name
Tyrosine-protein phosphatase non-receptor type 13
UniProt Synonym Protein Names
Fas-associated protein-tyrosine phosphatase 1; FAP-1; PTP-BAS; Protein-tyrosine phosphatase 1E; PTP-E1; hPTPE1; Protein-tyrosine phosphatase PTPL1
Protein Family
Tyrosine-protein phosphatase non-receptor
UniProt Gene Name
PTPN13
UniProt Synonym Gene Names
PNP1; PTP1E; PTPL1; FAP-1; PTP-E1; hPTPE1
NCBI Protein Information
tyrosine-protein phosphatase non-receptor type 13

NCBI Summary for PTPN13

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Oct 2008]
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UniProt Comments for PTPN13

PTPN13: Tyrosine phosphatase which regulates negatively FAS- induced apoptosis and NGFR-mediated pro-apoptotic signaling. Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)

Chromosomal Location of Human Ortholog: 4q21.3

Cellular Component: cytoplasm; lamellipodium; nucleus; plasma membrane

Molecular Function: protein binding; protein tyrosine phosphatase activity

Biological Process: protein amino acid dephosphorylation; regulation of phosphoinositide 3-kinase cascade
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Research Articles on PTPN13

1. PTPN13 overexpression significantly inhibited the progression of HCC cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PTPN13 antibody

 Reference Product  PubMed Publications
 FAS antibody  >80 publications with PTPN13 and FAS
 FASLG antibody  >18 publications with PTPN13 and FASLG
 FADD antibody  >10 publications with PTPN13 and FADD
 SRC antibody  >9 publications with PTPN13 and SRC
 TRIP6 antibody  >3 publications with PTPN13 and TRIP6
 RAPGEF6 antibody  >2 publications with PTPN13 and RAPGEF6
 EFNB1 antibody  >2 publications with PTPN13 and EFNB1
 EPHB2 antibody  >1 publications with PTPN13 and EPHB2
 PDCD10 antibody  >1 publications with PTPN13 and PDCD10

Pathways associated with anti-PTPN13 antibody

 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Ectoderm Differentiation Pathway antibodies  Ectoderm Differentiation Pathway Diagram
 Ephrin B Reverse Signaling Pathway antibodies  Ephrin B Reverse Signaling Pathway Diagram
 Fc-epsilon Receptor I Signaling In Mast Cells Pathway antibodies  Fc-epsilon Receptor I Signaling In Mast Cells Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 PI Metabolism Pathway antibodies  PI Metabolism Pathway Diagram
 Phospholipid Metabolism Pathway antibodies  Phospholipid Metabolism Pathway Diagram

Diseases associated with anti-PTPN13 antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >39 publications with PTPN13 and Carcinoma
 Adenocarcinoma Antibodies  >22 publications with PTPN13 and Adenocarcinoma
 Breast Neoplasms Antibodies  >15 publications with PTPN13 and Breast Neoplasms
 Colorectal Neoplasms Antibodies  >15 publications with PTPN13 and Colorectal Neoplasms
 Necrosis Antibodies  >14 publications with PTPN13 and Necrosis
 Carcinoma, Squamous Cell Antibodies  >11 publications with PTPN13 and Carcinoma, Squamous Cell
 Lung Neoplasms Antibodies  >11 publications with PTPN13 and Lung Neoplasms
 Liver Diseases Antibodies  >8 publications with PTPN13 and Liver Diseases
 Neoplasm Metastasis Antibodies  >7 publications with PTPN13 and Neoplasm Metastasis
 Carcinoma, Hepatocellular Antibodies  >6 publications with PTPN13 and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-PTPN13 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >13 publications with PTPN13 and Lung
 Brain Antibodies  >13 publications with PTPN13 and Brain
 Bone Antibodies  >8 publications with PTPN13 and Bone
 Thyroid Antibodies  >6 publications with PTPN13 and Thyroid
 Kidney Antibodies  >4 publications with PTPN13 and Kidney
 Testis Antibodies  >4 publications with PTPN13 and Testis
 Embryonic Tissue Antibodies  >3 publications with PTPN13 and Embryonic Tissue
 Mouth Antibodies  >2 publications with PTPN13 and Mouth
 Prostate Antibodies  >2 publications with PTPN13 and Prostate
 Muscle Antibodies  >2 publications with PTPN13 and Muscle
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