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MYD88 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS668958

MyD88 (Myeloid differentiation factor) is an essential adaptor molecule in all TLR (Toll-like receptor) signaling pathways except TLR3. MyD88 is composed of an N-terminal (Death Domain) and a highly conserved C-terminal TIR (Toll/interleukin-1 Receptor)… More details

$210 / 0.025 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
MyD88, Monoclonal Antibody
Full Product Name
Monoclonal Antibody to MyD88 (Clone: ABM2H20) FITC Conjugated
Product Gene Name
Product Synonym Names
Myeloid differentiation primary response protein MyD88
Clonality
Monoclonal
Isotype
IgG1 Kappa
Clone Number
ABM2H20
Host
Mouse
Species Reactivity
Human
Form/Format
0.2 mg/ml in Tris buffer containing 0.05% Azide
Purity/Purification
Purified
Protein G Chromatography
Preparation and Storage
Store the antibody at 4 degree C; stable for 6 months.
Molecular Weight
34,097 Da
OMIM
U70451 mRNA
3D Structure
ModBase 3D Structure for Q99836
Antigen
MyD88
Immunogen Information
A partial length recombinant protein of human MyD88 (amino acids 13-221) was used as an immunogen for this antibody.
Conjugation
FITC

Product Categories/Family for anti-MYD88 antibody

Applications Tested/Suitable for anti-MYD88 antibody
Flow Cytometry (FC/FACS)
Application Notes for anti-MYD88 antibody
FC/FACS analysis: 0.5-1 ug/ml

Flow Cytometry (FC/FACS) of anti-MYD88 antibody

Fig: 1-Intracellular flow analysis of MyD88 in PBMC using 0.5 ug/10^6 cells. Green represents isotype control; red represents FITC conjugated anti-MyD88 antibody (10-3012F).
Mouse Anti-MYD88 Monoclonal Antibody – Cat# MBS668958

Other Notes

Small volumes of anti-MYD88 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MYD88 purchase

MBS668958 is an antibody targeting MYD88. Also known as Monoclonal Antibody to MyD88 (Clone: ABM2H20) FITC Conjugated. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for MYD88. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
myeloid differentiation primary response protein MyD88 isoform 5
NCBI Official Synonym Full Names
myeloid differentiation primary response 88
NCBI Official Symbol
MYD88
NCBI Official Synonym Symbols
MYD88D
UniProt Protein Name
Myeloid differentiation primary response protein MyD88
UniProt Gene Name
MYD88
NCBI Protein Information
myeloid differentiation primary response protein MyD88

NCBI Summary for MYD88

This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
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UniProt Comments for MYD88

Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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