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IL-17A Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS668973

MBS668973 is an antibody targeting IL-17A. Also known as Monoclonal Antibody to IL-17A (Clone: ABM2B14). Reactive in Human. Host: Mouse. More details

$210 / 0.025 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IL-17A, Monoclonal Antibody
Full Product Name
Monoclonal Antibody to IL-17A (Clone: ABM2B14)
Product Gene Name
Product Synonym Gene Name
IL17A
Product Synonym Names
Interleukin-17A; Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8; Monoclonal Antibody to IL-17A (Clone: ABM2B14)
Clonality
Monoclonal
Isotype
IgG2a, Kappa
Clone Number
ABM2B14
Host
Mouse
Species Reactivity
Human
Form/Format
100 ug in 200 ul PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Purity/Purification
Purified
Protein G Chromatography
Preparation and Storage
Store the antibody at 4 degree C, stable for 6 months.
For long-term storage, store at -20 degree C.
Avoid repeat freezing and thawing
Molecular Weight
17,504 Da
OMIM
Z58820 mRNA
3D Structure
ModBase 3D Structure for Q16552
Antigen
IL17A
Immunogen Information
Full length recombinant protein of Interleukin-17A was used as the immunogen of this antibody.
Conjugation
Unconjugated

Product Categories/Family for anti-IL-17A antibody

Applications Tested/Suitable for anti-IL-17A antibody
Flow Cytometry (FC/FACS)
Application Notes for anti-IL-17A antibody
FC/FC/FACS: 2-4 ug/cells10^6 

Testing Data of anti-IL-17A antibody

Figure-1: Intracellular staining of IL-17A in PBMC treated with PMA (25ng/ml) and ionomycin (250ng/ml) for overnight, then Brefedin A (1x) was added to cells for 4hr prior to harvest. Anti- IL-17A (Clone: ABM2B14) was used at 2 ug/10^6 cells. Green represents isotype control; red represents Anti-IL-17A. Goat anti-mouse PE conjugate was used as secondary antibody.
Mouse Anti-IL-17A Monoclonal Antibody – Cat# MBS668973

Other Notes

Small volumes of anti-IL-17A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IL-17A. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
interleukin-17A
NCBI Official Synonym Full Names
interleukin 17A
NCBI Official Symbol
IL17A
NCBI Official Synonym Symbols
IL17; CTLA8; IL-17; CTLA-8; IL-17A
UniProt Protein Name
Interleukin-17A
UniProt Synonym Protein Names
Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8
Protein Family
UniProt Gene Name
IL17A
UniProt Synonym Gene Names
CTLA8; IL17; IL-17; IL-17A; CTLA-8
NCBI Protein Information
interleukin-17A

NCBI Summary for IL-17A

The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
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UniProt Comments for IL-17A

Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-IL-17A antibody

 Organ/Tissue Name  Pubmed Publications
 Mixed Antibodies  >78 publications with IL-17A and Mixed
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