• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

DNMT3a Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS669017

Dnmt3a belongs to the mammalian methyltransferase gene family which is responsible for tissue-specific gene expression. Dnmt3a together with other methyltransferases conducts de novo methylation of cytosine residues in CpG islands by the enzymatic addition of… More details

$385 / 0.1 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DNMT3a, Monoclonal Antibody
Full Product Name
Monoclonal Antibody to DNMT3a (Clone: ABM13G4) FITC Conjugated
Product Gene Name
Product Synonym Gene Name
DNMT3A
Product Synonym Names
DNA (cytosine-5)-methyltransferase 3A; DNA methyltransferase HsaIIIA; DNA MTase HsaIIIA; M.HsaIIIA
Clonality
Monoclonal
Isotype
IgG1, Kappa
Clone Number
ABM13G4
Host
Mouse
Species Reactivity
Human
Form/Format
Purified; 25ug in 125 ul/100ug in 500ul Tris and 0.05% sodium azide is highly toxic
Purity/Purification
Purified
Protein G Chromatography
Preparation and Storage
Store the antibody at 4 degree C, stable for 6 months.
OMIM
AF067972 mRNA
3D Structure
ModBase 3D Structure for Q9Y6K1
Antigen
DNMT3a
Immunogen Information
A partial length recombinant protein from DNMT3a was used as the immunogen for this antibody.
Conjugation
FITC
Applications Tested/Suitable for anti-DNMT3a antibody
Flow Cytometry (FC/FACS)
Application Notes for anti-DNMT3a antibody
FC/FACS: 0.5-1 ug/10^6

Flow Cytometry (FC/FACS) of anti-DNMT3a antibody

Fig-1: Intracellular FLOW staining of PMA treated Jurkat cells using 0.5 ug of antibody. Green represents FITC conjugated IgG1 isotype control, Red represents FITC conjugated DNMT3a (MBS669017).
Mouse Anti-DNMT3a Monoclonal Antibody – Cat# MBS669017

Other Notes

Small volumes of anti-DNMT3a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DNMT3a purchase

MBS669017 is an antibody targeting DNMT3a. Also known as Monoclonal Antibody to DNMT3a (Clone: ABM13G4) FITC Conjugated. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for DNMT3a. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
DNA (cytosine-5)-methyltransferase 3A isoform c
NCBI Official Synonym Full Names
DNA methyltransferase 3 alpha
NCBI Official Symbol
DNMT3A
NCBI Official Synonym Symbols
TBRS; DNMT3A2; M.HsaIIIA
UniProt Protein Name
DNA (cytosine-5)-methyltransferase 3A
UniProt Synonym Protein Names
DNA methyltransferase HsaIIIA; DNA MTase HsaIIIA; M.HsaIIIA
Protein Family
UniProt Gene Name
DNMT3A
UniProt Synonym Gene Names
Dnmt3a; DNA MTase HsaIIIA; M.HsaIIIA
NCBI Protein Information
DNA (cytosine-5)-methyltransferase 3A

NCBI Summary for DNMT3a

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. [provided by RefSeq, Mar 2016]
Show more

UniProt Comments for DNMT3a

Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000