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FSH Receptor (FSHR) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS669032

FSH receptor is a member of the G protein coupled receptor family consisting of 9 introns and 10 exons and a promoter region and is located on chromosome 2p21. FSH receptor was shown to be expressed selectively on the luminal surface of tumor blood vessels. A… More details

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Product Overview

Online Datasheet in PDF
Product Name
FSH Receptor (FSHR), Monoclonal Antibody
Full Product Name
Monoclonal Antibody to FSH Receptor (Clone: ABM5D29)
Product Gene Name
anti-FSHR antibody
Product Synonym Names
Follicle-stimulating hormone receptor; FSH-R; Follitropin receptor
Clonality
Monoclonal
Isotype
IgG1, Kappa
Clone Number
ABM5D29
Host
Mouse
Species Reactivity
Human
Form/Format
25 ug in 50 uL/100 ug in 200 uL PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Purity/Purification
Purified
Protein G Chromatography
Preparation and Storage
Store the antibody at 4°C; stable for 6 months.
For long-term storage; store at -20°C.
Avoid repeated freeze and thaw cycles.
OMIM
M65085 mRNA
3D Structure
ModBase 3D Structure for P23945
Antigen
FSH Receptor
Immunogen Information
A partial length recombinant protein (a.a 03-200) of FSH Receptor was used as the immunogen for this antibody.
Conjugation
Unconjugated

Product Categories/Family for anti-FSHR antibody

Cancer Marker
Applications Tested/Suitable for anti-FSHR antibody
Western Blot (WB), Flow Cytometry (FC/FACS)
Application Notes for anti-FSHR antibody
WB: 2-4 ug/ml
FC/FACS: 0.5-1 ug/10^6

Western Blot (WB) of anti-FSHR antibody

Fig-1: Western blot analysis of FSH Receptor. Anti-FSH Receptor antibody (Clone: ABM5D29) was used at 2 ug/ml on Hela lysate.
Mouse Anti-FSHR Monoclonal Antibody – Cat# MBS669032

Flow Cytometry (FC/FACS) of anti-FSHR antibody

Fig-2: Intracellular flow analysis of FSH receptor antibody on A431 cells using 0.5 ug/10^6 cells (Clone: ABM5D29). Green represents isotype control; red represents anti-FSH receptor antibody. Goat anti-mouse PE conjugate was used as secondary antibody. (Cells were fixed with 4% paraformaldehyde for 10 min and washed with PBS by centrifuging at 1100 for 5 min followed by permeabilization for 20 min and washed again as mentioned above. Then cell were incubated with primary antibody for 45 min. and after washing the cells twice in PBS, incubated with conjugated secondary antibody for 30 min. Data acquisition was done after washing twice with PBS as mentioned above).
Mouse Anti-FSHR Monoclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS669032

Flow Cytometry (FC/FACS) of anti-FSHR antibody

Fig-3: Intracellular flow analysis of FSH receptor antibody on HeLa cells using 0.5 ug/10^6 cells (Clone: ABM5D29). Green represents isotype control; red represents anti-FSH receptor antibody. Goat anti-mouse PE conjugate was used as secondary. (Cells were fixed with 4% paraformaldehyde for 10 min and washed with PBS by centrifuging at 1100 for 5 min followed by permeabilization for 20 min and washed again as mentioned above. Then cell were incubated with primary antibody for 45 min. and after washing the cells twice in PBS, incubated with conjugated secondary antibody for 30 min. Data acquisition was done after washing twice with PBS as mentioned above).
Mouse Anti-FSHR Monoclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS669032

Other Notes

Small volumes of anti-FSHR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FSHR purchase

MBS669032 is an antibody targeting FSHR. Also known as Monoclonal Antibody to FSH Receptor (Clone: ABM5D29). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for FSHR. It may not necessarily be applicable to this product.

NCBI GI #
31657138
NCBI GeneID
2492
NCBI Accession #
NP_000136.2
UniProt Primary Accession #
P23945
UniProt Secondary Accession #
Q05AH0; Q16225; Q4QRJ3; Q4ZFZ2; Q53RW2; A0A0A0MSC5; A8K947; G5CBS7; G5E967; J3KQ00
UniProt Related Accession #
P23945
GenBank Nucleotide #
NM_000145.3
NCBI Official Full Name
follicle-stimulating hormone receptor isoform 1
NCBI Official Synonym Full Names
follicle stimulating hormone receptor
NCBI Official Symbol
FSHR
NCBI Official Synonym Symbols
LGR1; ODG1; FSHR1; FSHRO
UniProt Protein Name
Follicle-stimulating hormone receptor
UniProt Synonym Protein Names
Follitropin receptor
Protein Family
Follicle-stimulating hormone receptor
UniProt Gene Name
FSHR
UniProt Synonym Gene Names
LGR1; FSH-R
NCBI Protein Information
follicle-stimulating hormone receptor

NCBI Summary for FSHR

The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
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UniProt Comments for FSHR

Receptor for follicle-stimulating hormone or follitropin (PubMed:11847099, PubMed:24058690). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099). Induces cAMP production through the activation of PI3K-AKT and SRC-ERK1/2 signaling pathways (PubMed:24058690).
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Research Articles on FSHR

1. T cells redirected against FSHR(+) tumor cells with full-length FSH represent a promising therapeutic alternative against a broad range of ovarian malignancies, with negligible toxicity even in the presence of cognate targets in tumor-free ovaries

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FSHR antibody

 Reference Product  PubMed Publications
 FSHB antibody  >16 publications with FSHR and FSHB
 APPL1 antibody  >4 publications with FSHR and APPL1
 GRK4 antibody  >1 publications with FSHR and GRK4
 AKT2 antibody  >1 publications with FSHR and AKT2

Pathways associated with anti-FSHR antibody

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 FSH Signaling Pathway antibodies  FSH Signaling Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 GPCRs, Other Pathway antibodies  GPCRs, Other Pathway Diagram
 Hormone Ligand-binding Receptors Pathway antibodies  Hormone Ligand-binding Receptors Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with anti-FSHR antibody

 Disease Name  Pubmed Publications
 Genital Diseases, Female Antibodies  >113 publications with FSHR and Genital Diseases, Female
 Ovarian Diseases Antibodies  >89 publications with FSHR and Ovarian Diseases
 Infertility, Female Antibodies  >62 publications with FSHR and Infertility, Female
 Neoplasms Antibodies  >59 publications with FSHR and Neoplasms
 Infertility, Male Antibodies  >44 publications with FSHR and Infertility, Male
 Genital Diseases, Male Antibodies  >38 publications with FSHR and Genital Diseases, Male
 Polycystic Ovary Syndrome Antibodies  >26 publications with FSHR and Polycystic Ovary Syndrome
 Ovarian Hyperstimulation Syndrome Antibodies  >25 publications with FSHR and Ovarian Hyperstimulation Syndrome
 Drug Toxicity Antibodies  >12 publications with FSHR and Drug Toxicity
 Disorders of Sex Development Antibodies  >11 publications with FSHR and Disorders of Sex Development

Organs/Tissues associated with anti-FSHR antibody

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >119 publications with FSHR and Testis
 Mixed Antibodies  >1 publications with FSHR and Mixed
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