• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

CD74w Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS669145

CD74, a Type-II transmembrane protein, is a unique member of RIP-processed protein family. It consists of an extracytoplasmic domain, a transmembrane segment and an intracytoplasmic domain. It is expressed in B-cells, monocytes, macrophages and other Class II… More details

$685 / 0.1 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD74w, Monoclonal Antibody
Full Product Name
Monoclonal Antibody to CD74w (Clone: LN-2)
Product Gene Name
anti-CD74w antibody
Product Synonym Gene Name
CD74
Product Synonym Names
CD74; DHLAG; HLA-DR antigens-associated invariant chain; Ii; Ia antigen-associated invariant chain; p33
Clonality
Monoclonal
Isotype
IgG1 Kappa
Clone Number
LN-2
Host
Mouse
Species Reactivity
Human
Form/Format
100 ug in 200 ul PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Purity/Purification
Purified
Protein G Chromatography
Preparation and Storage
Store the antibody at 4 degree C; stable for 6 months.
For long-term storage; store at -20 degree C.
Avoid repeated freeze and thaw cycles.
Molecular Weight
18,328 Da
OMIM
K01144 mRNA
3D Structure
ModBase 3D Structure for P04233
Antigen
CD74w
Immunogen Information
SU-DHL-4 lymphoma cells were used as the immunogen for the CD74 antibody.
Conjugation
Unconjugated

Product Categories/Family for anti-CD74w antibody

Cancer Marker
Applications Tested/Suitable for anti-CD74w antibody
Immunohistochemistry (IHC)
Application Notes for anti-CD74w antibody
IHC analysis: 1: 200-1: 400

Flow Cytometry (FC/FACS) of anti-CD74w antibody

Fig: 1 Immunohistochemical analysis of CD74w in human tonsil tissue using CD74w antibody (Clone: LN-2) at 1: 200 dilution.
Mouse Anti-CD74w Monoclonal Antibody – Cat# MBS669145

Other Notes

Small volumes of anti-CD74w antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD74w purchase

MBS669145 is an antibody targeting CD74w. Also known as Monoclonal Antibody to CD74w (Clone: LN-2). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD74w. It may not necessarily be applicable to this product.

NCBI GI #
68448537
NCBI GeneID
972
NCBI Accession #
NP_001020329.1
UniProt Primary Accession #
P04233
UniProt Secondary Accession #
Q14597; Q29832; Q5U0J8; Q8SNA0; Q8WLP6; A8K7R1; B4DNE8; D3DQG3; D3DQG4
UniProt Related Accession #
P04233
GenBank Nucleotide #
NM_001025158.2
NCBI Official Full Name
HLA class II histocompatibility antigen gamma chain isoform c
NCBI Official Synonym Full Names
CD74 molecule
NCBI Official Symbol
CD74
NCBI Official Synonym Symbols
II; DHLAG; HLADG; Ia-GAMMA
UniProt Protein Name
HLA class II histocompatibility antigen gamma chain
UniProt Synonym Protein Names
HLA-DR antigens-associated invariant chain; Ia antigen-associated invariant chain; Ii; p33; CD_antigen: CD74
UniProt Gene Name
CD74
UniProt Synonym Gene Names
DHLAG; Ii
NCBI Protein Information
HLA class II histocompatibility antigen gamma chain

NCBI Summary for CD74w

The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Show more

UniProt Comments for CD74w

Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.
Show more

Research Articles on CD74w

1. The data validate CD74 as a useful prognostic tumor cell protein marker associated with favorable recurrence-free survival and overall survival in stage III melanoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD74w antibody

 Reference Product  PubMed Publications
 MIF antibody  >198 publications with CD74w and MIF
 HLA-DRB1 antibody  >6 publications with CD74w and HLA-DRB1

Pathways associated with anti-CD74w antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 MHC Class II Antigen Presentation Pathway antibodies  MHC Class II Antigen Presentation Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram

Diseases associated with anti-CD74w antibody

 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >120 publications with CD74w and Immune System Diseases
 Inflammation Antibodies  >101 publications with CD74w and Inflammation
 Carcinoma Antibodies  >73 publications with CD74w and Carcinoma
 Adenocarcinoma Antibodies  >43 publications with CD74w and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >39 publications with CD74w and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >39 publications with CD74w and Disease Models, Animal
 Lung Neoplasms Antibodies  >33 publications with CD74w and Lung Neoplasms
 Brain Diseases Antibodies  >24 publications with CD74w and Brain Diseases
 Necrosis Antibodies  >19 publications with CD74w and Necrosis
 Carcinoma, Non-Small-Cell Lung Antibodies  >19 publications with CD74w and Carcinoma, Non-Small-Cell Lung

Organs/Tissues associated with anti-CD74w antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >170 publications with CD74w and Blood
 Lung Antibodies  >62 publications with CD74w and Lung
 Brain Antibodies  >50 publications with CD74w and Brain
 Bone Antibodies  >42 publications with CD74w and Bone
 Bone Marrow Antibodies  >33 publications with CD74w and Bone Marrow
 Vascular Antibodies  >29 publications with CD74w and Vascular
 Lymph Antibodies  >27 publications with CD74w and Lymph
 Lymph Node Antibodies  >25 publications with CD74w and Lymph Node
 Kidney Antibodies  >24 publications with CD74w and Kidney
 Skin Antibodies  >21 publications with CD74w and Skin
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000