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PD-1 Antibody – Rat Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS669261

MBS669261 is an antibody targeting PD-1. Also known as Monoclonal Antibody to Mouse PD-1 (29F.1A12). Reactive in Mouse. Host: Rat. More details

$210 / 0.025 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PD-1, Monoclonal Antibody
Full Product Name
Monoclonal Antibody to Mouse PD-1 (29F.1A12)
Product Gene Name
anti-PD-1 antibody
Product Synonym Gene Name
Pdcd1
Product Synonym Names
Programmed cell death protein 1; Pdcd1; 18566; Q02242; Programmed cell death protein 1; CD279; mPD-1
Clonality
Monoclonal
Isotype
IgG2a, Kappa
Clone Number
29F.1A12
Host
Rat
Species Reactivity
Mouse
Form/Format
100 ug in 200 ul PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Purity/Purification
Protein G Chromatography Purified
Preparation and Storage
Store the antibody at 4 degree C, stable for 6 months. For long-term storage, store at -20 degree C. Avoid repeated freeze and thaw cycles.
Molecular Weight
31,842 Da
3D Structure
ModBase 3D Structure for Q02242
Immunogen
Programmed cell death protein 1
Immunogen Information
Recombinant PD-1-Ig fusion protein was used as the immunogen for this antibody.
Conjugation
Unconjugated

Product Categories/Family for anti-PD-1 antibody

Cancer Marker
Applications Tested/Suitable for anti-PD-1 antibody
Flow Cytometry (FC/FACS)
Application Notes for anti-PD-1 antibody
FC/FACS: 0.2-0.4 ug/10^6 Cells

Flow Cytometry (FC/FACS) of anti-PD-1 antibody

Figure 1: Cell surface staining of splenocytes stimulated with ConA + mIL2 for 3 days. Green represents Rat isotope control, red represents Anti-mouse PD-1 (10-7647). 0.2 ug antibodies were used. Goat anti-rat PE was used as secondary antibody.
Rat Anti-PD-1 Monoclonal Antibody – Cat# MBS669261

Other Notes

Small volumes of anti-PD-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PD-1. It may not necessarily be applicable to this product.

NCBI GI #
6679239
NCBI GeneID
18566
NCBI Accession #
NP_032824.1
UniProt Primary Accession #
Q02242
UniProt Related Accession #
Q02242
GenBank Nucleotide #
NM_008798.2
NCBI Official Full Name
programmed cell death protein 1
NCBI Official Synonym Full Names
programmed cell death 1
NCBI Official Symbol
Pdcd1
NCBI Official Synonym Symbols
PD-1; Pdc1; Ly101
UniProt Protein Name
Programmed cell death protein 1
UniProt Synonym Protein Names
CD_antigen: CD279
UniProt Gene Name
Pdcd1
UniProt Synonym Gene Names
Pd1; Protein PD-1; mPD-1
NCBI Protein Information
programmed cell death protein 1

UniProt Comments for PD-1

Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors ().

Research Articles on PD-1

1. These results show that PD-1 plays an inhibitory role during the naive-to-effector CD8 T cell transition and that the PD-1 pathway can also be modulated at this stage of T cell differentiation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PD-1 antibody

 Reference Product  PubMed Publications
 Cd274 antibody  >1020 publications with PD-1 and Cd274
 Pdcd1lg2 antibody  >151 publications with PD-1 and Pdcd1lg2
 Ptpn11 antibody  >10 publications with PD-1 and Ptpn11
 Ptpn6 antibody  >7 publications with PD-1 and Ptpn6
 Lck antibody  >5 publications with PD-1 and Lck
 Cd3e antibody  >2 publications with PD-1 and Cd3e

Pathways associated with anti-PD-1 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 PD-1 Signaling Pathway antibodies  PD-1 Signaling Pathway Diagram
 T Cell Receptor Signaling Pathway antibodies  T Cell Receptor Signaling Pathway Diagram
 T Cell Receptor Signaling Pathway antibodies  T Cell Receptor Signaling Pathway Diagram

Diseases associated with anti-PD-1 antibody

 Disease Name  Pubmed Publications
 Melanoma Antibodies  >735 publications with PD-1 and Melanoma
 Lung Neoplasms Antibodies  >514 publications with PD-1 and Lung Neoplasms
 Lung Diseases Antibodies  >484 publications with PD-1 and Lung Diseases
 Inflammation Antibodies  >331 publications with PD-1 and Inflammation
 Adenocarcinoma Antibodies  >301 publications with PD-1 and Adenocarcinoma
 Liver Diseases Antibodies  >290 publications with PD-1 and Liver Diseases
 Necrosis Antibodies  >215 publications with PD-1 and Necrosis
 Kidney Diseases Antibodies  >161 publications with PD-1 and Kidney Diseases
 Cardiovascular Diseases Antibodies  >117 publications with PD-1 and Cardiovascular Diseases
 Liver Neoplasms Antibodies  >105 publications with PD-1 and Liver Neoplasms

Organs/Tissues associated with anti-PD-1 antibody

 Organ/Tissue Name  Pubmed Publications
 Thymus Antibodies  >43 publications with PD-1 and Thymus
 Uncharacterized Tissue Antibodies  >1 publications with PD-1 and Uncharacterized Tissue
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