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Il-13 (IL13) Antibody – Rat Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS670055

MBS670055 is an antibody targeting IL13. Also known as Rat Anti-Human IL-13-UNLB. Reactive in Human. Host: Rat. More details

$415 / 0.5 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
IL-13 (IL13), Monoclonal Antibody
Full Product Name
Rat Anti-Human IL-13-UNLB
Product Gene Name
anti-IL13 antibody
Product Synonym Names
Rat Anti-Human IL-13 - Purified, Unlabeled Antibody; Rat Anti-Human IL-13
Clonality
Monoclonal
Isotype
Rat IgG1 kappa
Clone Number
JES10-2E10
Host
Rat
Species Reactivity
Human
Form/Format
Purified (UNLB) Antibody
Specificity
Human Interleukin-13 (IL-13)1,2 (This is a neutralizing antibody.)
Preparation and Storage
The purified (UNLB) antibody is supplied as 0.5 mg purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. Store at 2- 8 degree C.
The biotin (BIOT) conjugate is supplied as 0.5 mg labeled antibody in 1.0 mL of PBS/NaN3. Store at 2-8 degree C.
Reagents are stable for the period shown on the label if stored as directed.
Molecular Weight
15,816 Da
Chromosome Location
Chromosome: 5; NC_000005.9 (131993865..131996801). Location: 5q31
OMIM
147683
3D Structure
ModBase 3D Structure for P35225
Immunogen
COS-expressed recombinant human IL-13
Characterization
To ensure acceptable performance, each batch of product is tested in a sandwich ELISA to conform to characteristics of a standard reference reagent.
Applications Tested/Suitable for anti-IL13 antibody
ELISA; Western Blot
Application Notes for anti-IL13 antibody
Research Application(s): ELISA Detection: JES10-2E10 monoclonal antibody is useful as a detection antibody in a sandwich ELISA for quantifying human IL-13 protein levels.1,2 Biotinylated JES10-2E10 antibody should be paired with purified JES- 35G12 antibody or JES10-5A2 as the capture antibody, with purified recombinant human IL-13 as the standard.
Western Blotting: The purified JES10-2E10 antibody is also useful for Western blotting applications. A concentration of 1-5 ug/mL (in conjunction with AP-labeled Goat Anti-Rat-Ig) has been found to enable detection of <= 100 ng/lane of recombinant human IL-13 under reducing conditions.
Since applications vary, each investigator should determine the optimal concentration appropriate for individual applications.

Product References and Citations for anti-IL13 antibody

1. McKenzie, A., and G. Zurawski. 1994. Measurement of IL-13. In Current Protocols in Immunology (J. Coligamn, A. Kruisbeek, D. Margulies, E. Shevach, W. Strober, eds.). John Wiley and Sons, New York. Unit 6.18.
2. Abrams, J. 1995. Immunoenzymetric assay of mouse and human cytokines using NIP-labeled anti-cytokine antibodies. In Current Protocols in Immunology (J. Coligamn, A. Kruisbeek, D. Margulies, E. Shevach, W. Strober, eds.). John Wiley and Sons, New York. Unit 6.20.

Other Notes

Small volumes of anti-IL13 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IL13. It may not necessarily be applicable to this product.

NCBI GI #
1045452
NCBI GeneID
3596
UniProt Primary Accession #
P35225
UniProt Secondary Accession #
O43644; Q4VB52; Q9UDC7
UniProt Related Accession #
P35225; Q4VB50; Q4VB51; Q4VB53
NCBI Official Full Name
interleukin-13
NCBI Official Synonym Full Names
interleukin 13
NCBI Official Symbol
IL13
NCBI Official Synonym Symbols
ALRH; BHR1; P600; IL-13; MGC116786; MGC116788; MGC116789
UniProt Protein Name
Interleukin-13
Protein Family
Interleukin
UniProt Gene Name
IL13
UniProt Synonym Gene Names
NC30
UniProt Entry Name
IL13_HUMAN
NCBI Protein Information
interleukin-13; allergic rhinitis; OTTHUMP00000066048; Bronchial hyperresponsiveness-1 (bronchial asthma)

NCBI Summary for IL13

This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq]
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UniProt Comments for IL13

Function: Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.

Subunit structure: Interacts with IL13RA2.

Subcellular location: Secreted.

Involvement in disease: Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [

MIM:607154]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure.

Sequence similarities: Belongs to the IL-4/IL-13 family.

Caution: It is uncertain whether Met-1 or Met-15 is the initiator.

Sequence caution: The sequence AAA36107.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAA83738.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAB01681.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAC03535.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAK53823.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence CAA48824.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
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Research Articles on IL13

1. Epigenetic regulation of the IL-13-induced human eotaxin-3 gene by CREB-binding protein-mediated histone 3 acetylation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IL13 antibody

 Reference Product  PubMed Publications
 IL13RA1 antibody  >272 publications with IL13 and IL13RA1
 IL4R antibody  >41 publications with IL13 and IL4R
 IL13RA2 antibody  >10 publications with IL13 and IL13RA2
 VCAM1 antibody  >4 publications with IL13 and VCAM1

Pathways associated with anti-IL13 antibody

 Products by Pathway  Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokines And Inflammatory Response Pathway antibodies  Cytokines And Inflammatory Response Pathway Diagram
 Fc Epsilon RI Signaling Pathway antibodies  Fc Epsilon RI Signaling Pathway Diagram
 Fc Epsilon RI Signaling Pathway antibodies  Fc Epsilon RI Signaling Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram
 IL12 Signaling Mediated By STAT4 Pathway antibodies  IL12 Signaling Mediated By STAT4 Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram

Diseases associated with anti-IL13 antibody

 Disease Name  Pubmed Publications
 Hypersensitivity Antibodies  >984 publications with IL13 and Hypersensitivity
 Inflammation Antibodies  >914 publications with IL13 and Inflammation
 Asthma Antibodies  >895 publications with IL13 and Asthma
 Hypersensitivity, Immediate Antibodies  >849 publications with IL13 and Hypersensitivity, Immediate
 Lung Diseases Antibodies  >839 publications with IL13 and Lung Diseases
 Respiratory Hypersensitivity Antibodies  >711 publications with IL13 and Respiratory Hypersensitivity
 Neoplasms Antibodies  >382 publications with IL13 and Neoplasms
 Eosinophilia Antibodies  >235 publications with IL13 and Eosinophilia
 Fibrosis Antibodies  >228 publications with IL13 and Fibrosis
 Bronchial Hyperreactivity Antibodies  >178 publications with IL13 and Bronchial Hyperreactivity

Organs/Tissues associated with anti-IL13 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >137 publications with IL13 and Brain
 Bone Marrow Antibodies  >109 publications with IL13 and Bone Marrow
 Mixed Antibodies  >58 publications with IL13 and Mixed
 Testis Antibodies  >5 publications with IL13 and Testis
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