Rat Anti-IL4 Monoclonal Antibody – Cat# MBS670068

Il-4 (IL4) Antibody – Rat Monoclonal

Name: IL4 Antibody; Monoclonal; Rat; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS670068
Price: 365 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS670068

MBS670068 is an antibody targeting IL4. Also known as Rat Anti-Mouse IL-4-UNLB. Reactive in Mouse. Host: Rat. More details

$365 / 0.5 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

IL-4 (IL4), Monoclonal Antibody

Full Product Name

Rat Anti-Mouse IL-4-UNLB

Product Gene Name

anti-IL4 antibody

Product Synonym Names

Rat Anti-Mouse IL-4 - Purified, Unlabeled Antibody; Rat Anti-Mouse IL-4

Clonality

Monoclonal

Isotype

Rat IgG1 kappa

Clone Number

BVD6-24G2

Host

Rat

Species Reactivity

Mouse

Form/Format

Purified (UNLB) Antibody

Specificity

Mouse Interleukin-4 (IL-4)1,2 This is a non-neutralizing antibody.

Preparation and Storage

The purified (UNLB) antibody is supplied as 0.5 mg purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. Store at 2- 8 degree C.
The biotin (BIOT) conjugate is supplied as 0.5 mg labeled antibody in 1.0 mL of PBS/NaN3. Store at 2-8 degree C.
Reagents are stable for the period shown on the label if stored as directed.

Molecular Weight

15,023 Da

Chromosome Location

Chromosome: 2; NC_010444.2 (140218906..140226454). Location: 2; 2

3D Structure

ModBase 3D Structure for Q04745

Immunogen

E. coli-expressed recombinant mouse IL-4

Characterization

To ensure acceptable performance, each batch of product is tested in a sandwich ELISA to conform to characteristics of a standard reference reagent.

Applications Tested/Suitable for anti-IL4 antibody

ELISA

Application Notes for anti-IL4 antibody

Research Application(s): ELISA Detection: BVD6-24G2 monoclonal antibody is useful as a detection antibody in a sandwich ELISA for quantifying mouse IL-4 protein levels.3-5 Biotinylated BVD6-24G2 antibody should be paired with purified BVD4-1D11 antibody as the capture antibody, with purified recombinant mouse IL-4 as the standard.
Since applications vary, each investigator should determine the optimal concentration appropriate for individual applications.

Product References and Citations for anti-IL4 antibody

1. Abrams, J.S., M.-G. Roncarolo, H.. Yssel, U. Andersson, G.J. Gleich, and J.E., Silver. 1992. Strategies of anti-cytokine monoclonal antibody development: Immunoassay of IL-10 and IL-5 in clinical samples. Immunol. Rev. 127:5-24.
2. Sander, B., I. Hoiden, U. Andersson, E. Moller, and J. Abrams. 1993. Similar frequencies and kinetics of cytokine producing cells in murine peripheral blood and sera. J. Immunol. Meth. 166:201-214.
3. Chatelain, R., K. Varkila, and R. Coffman. 1991. IL-4 induces a Th2 response in Leishmania major-infected mice. J. Immunol. 148:1182- 1187.
4. Bogen, S., I. Fogelman, and A. Abbas. 1993. Analysis of IL-2, IL-4, and IFN- gamma -producing cells in situ during immune responses to protein antigens. J. Immunol. 150: 4197-4205.
5. Shirai, A., V. Sierra, C. Kelly, and D. Klinman. 1994. Individual cells simultaneously produce both IL-4 and IL-6 in vivo. Cytokine 6:329- 336.

Other Notes

Small volumes of anti-IL4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IL4. It may not necessarily be applicable to this product.

NCBI GI #

55742622

NCBI GeneID

397225

NCBI Accession #

NP_999288.1

UniProt Primary Accession #

Q04745

UniProt Secondary Accession #

Q29054; Q8MKE6

UniProt Related Accession #

Q04745

GenBank Nucleotide #

NM_214123.1

NCBI Official Full Name

interleukin-4

NCBI Official Symbol

IL4

UniProt Protein Name

Interleukin-4

UniProt Synonym Protein Names

B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1

Protein Family

Interleukin

UniProt Gene Name

IL4

UniProt Entry Name

IL4_PIG

NCBI Protein Information

interleukin-4; IL-4; BSF-1; B-cell stimulatory factor 1; lymphocyte stimulatory factor 1

UniProt Comments for IL4

Function: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.

Subcellular location: Secreted.

Sequence similarities: Belongs to the IL-4/IL-13 family.

Research Articles on IL4

1. IL-4 induced activation of Akt/SREBP-1/lipid biosynthesis in EC, resulting in protection against membrane attack complex and melittin, in association with mitochondrial protection.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-IL4 antibody

Products by Pathway	Pathway Diagram
Allograft Rejection Pathway antibodies	Allograft Rejection Pathway Diagram
Allograft Rejection Pathway antibodies	Allograft Rejection Pathway Diagram
Asthma Pathway antibodies	Asthma Pathway Diagram
Asthma Pathway antibodies	Asthma Pathway Diagram
Autoimmune Thyroid Disease Pathway antibodies	Autoimmune Thyroid Disease Pathway Diagram
Autoimmune Thyroid Disease Pathway antibodies	Autoimmune Thyroid Disease Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Fc Epsilon RI Signaling Pathway antibodies	Fc Epsilon RI Signaling Pathway Diagram
Fc Epsilon RI Signaling Pathway antibodies	Fc Epsilon RI Signaling Pathway Diagram

Diseases associated with anti-IL4 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>237 publications with IL4 and Neoplasms
Hypersensitivity Antibodies	>211 publications with IL4 and Hypersensitivity
Inflammation Antibodies	>191 publications with IL4 and Inflammation
Hypersensitivity, Immediate Antibodies	>167 publications with IL4 and Hypersensitivity, Immediate
Asthma Antibodies	>144 publications with IL4 and Asthma
Lung Diseases Antibodies	>134 publications with IL4 and Lung Diseases
Respiratory Hypersensitivity Antibodies	>124 publications with IL4 and Respiratory Hypersensitivity
Leukemia Antibodies	>64 publications with IL4 and Leukemia
Lymphoma Antibodies	>56 publications with IL4 and Lymphoma
Intestinal Diseases Antibodies	>53 publications with IL4 and Intestinal Diseases