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IL17A Antibody – Rat Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS670091

MBS670091 is an antibody targeting IL17A. Also known as Rat Anti-Mouse IL-17-LE/AF. Reactive in Mouse. Host: Rat. More details

$445 / 0.5 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IL-17 (IL17A), Monoclonal Antibody
Full Product Name
Rat Anti-Mouse IL-17-LE/AF
Product Gene Name
anti-IL17A antibody
Product Synonym Names
Rat Anti-Mouse IL-17 - Low Endotoxin/Azide-Free; Rat Anti-Mouse IL-17
Clonality
Monoclonal
Isotype
Rat IgG1 kappa
Clone Number
TC11-18H10
Host
Rat
Species Reactivity
Mouse
Form/Format
Low Endotoxin, Azide - Free (LE/AF)
Specificity
Mouse Interleukin-17 (IL-17)
Preparation and Storage
The purified (UNLB) antibody is supplied as 0.5 mg purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. Store at 2- 8 degree C.
The low endotoxin, azide-free (LE/AF) antibody is supplied as 0.5 mg purified immunoglobulin in 1.0 mL of PBS. Aliquot and store at or below -20 degree C.
Protect conjugated forms from light. Aliquot and freeze the low endotoxin, azide-free product at -20 degree C immediately upon receipt. Each reagent is stable for the period shown on the bottle label if stored as directed.
Molecular Weight
17,504 Da
Chromosome Location
Chromosome: 6; NC_000006.11 (52051185..52055436). Location: 6p12
OMIM
603149
3D Structure
ModBase 3D Structure for Q16552
Immunogen
E. coli-expressed recombinant mouse IL-17
Characterization
To ensure acceptable performance, each batch of product is tested in a sandwich ELISA to conform to characteristics of a standard reference reagent.
Applications Tested/Suitable for anti-IL17A antibody
ELISA; Flow Cytometry; Immunofluorescence; Western Blot
Application Notes for anti-IL17A antibody
Research Application(s): ELISA Capture: TC11-18H10 monoclonal antibody is useful as a capture antibody in a sandwich ELISA for quantifying mouse IL-17 protein levels. Purified TC11-18H10 antibody should be paired with biotinylated TC11-8H4 antibody as the detection antibody, with purified recombinant mouse IL-17 as the standard.
Immunofluorescence/Flow Cytometry: TC11-18H10 antibody is useful for intracytoplasmic staining and flow cytometric analysis to identify and enumerate IL-17-positive cells within mixed cell populations. Rat IgG1 should be used as a specificity control. Western Blotting: The purified TC11-18H10 antibody is also useful for Western blotting applications. For Western blotting, a concentration of 1-5 ug/mL (in conjunction with AP-labeled Goat Anti-Rat-Ig) has been found to enable detection of <= 100 ng/lane of recombinant mouse IL-17 under reducing conditions.
Neutralization: The LE/AF form of TC11-18H10 can be used for neutralizing mouse IL-17 bioactivity. A suitable LE/AF Rat IgG1 should be used as an isotype control.
Since applications vary, each investigator should determine the optimal concentration appropriate for individual applications.

Other Notes

Small volumes of anti-IL17A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IL17A. It may not necessarily be applicable to this product.

NCBI GI #
1155223
NCBI GeneID
3605
NCBI Accession #
AAC50341.1
UniProt Primary Accession #
Q16552
UniProt Secondary Accession #
Q5T2P0
UniProt Related Accession #
Q16552
NCBI Official Full Name
IL-17
NCBI Official Synonym Full Names
interleukin 17A
NCBI Official Symbol
IL17A
NCBI Official Synonym Symbols
IL17; CTLA8; IL-17; IL-17A
UniProt Protein Name
Interleukin-17A
UniProt Synonym Protein Names
Cytotoxic T-lymphocyte-associated antigen 8
Protein Family
Interleukin
UniProt Gene Name
IL17A
UniProt Synonym Gene Names
CTLA8; IL17; IL-17; IL-17A; CTLA-8
UniProt Entry Name
IL17_HUMAN
NCBI Protein Information
interleukin-17A; CTLA-8; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)

NCBI Summary for IL17A

The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
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UniProt Comments for IL17A

Function: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts.

Subunit structure: Homodimer. Ref.8

Subcellular location: Secreted.

Tissue specificity: Restricted to activated memory T-cells.

Post-translational modification: Found both in glycosylated and nonglycosylated forms.

Sequence similarities: Belongs to the IL-17 family.
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Research Articles on IL17A

1. Decreased IL-17 expression in intestinal mucosa of patients with inflammatory bowel disease strongly correlate with endoscopic response and mucosal healing following infliximab therapy

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IL17A antibody

 Reference Product  PubMed Publications
 FOXP3 antibody  >536 publications with IL17A and FOXP3
 STAT3 antibody  >229 publications with IL17A and STAT3
 TGFB1 antibody  >113 publications with IL17A and TGFB1
 IL17RA antibody  >92 publications with IL17A and IL17RA
 IL6 antibody  >81 publications with IL17A and IL6
 STAT1 antibody  >74 publications with IL17A and STAT1
 IL23A antibody  >57 publications with IL17A and IL23A
 IL17RC antibody  >18 publications with IL17A and IL17RC
 NFKB1 antibody  >1 publications with IL17A and NFKB1

Pathways associated with anti-IL17A antibody

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 IL23-mediated Signaling Events Pathway antibodies  IL23-mediated Signaling Events Pathway Diagram
 IL27-mediated Signaling Events Pathway antibodies  IL27-mediated Signaling Events Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram
 Rheumatoid Arthritis Pathway antibodies  Rheumatoid Arthritis Pathway Diagram
 Rheumatoid Arthritis Pathway antibodies  Rheumatoid Arthritis Pathway Diagram
 TCR Signaling Pathway antibodies  TCR Signaling Pathway Diagram

Diseases associated with anti-IL17A antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1930 publications with IL17A and Inflammation
 Autoimmune Diseases Antibodies  >1563 publications with IL17A and Autoimmune Diseases
 Necrosis Antibodies  >799 publications with IL17A and Necrosis
 Nervous System Diseases Antibodies  >599 publications with IL17A and Nervous System Diseases
 Respiratory Tract Diseases Antibodies  >545 publications with IL17A and Respiratory Tract Diseases
 Lung Diseases Antibodies  >476 publications with IL17A and Lung Diseases
 Central Nervous System Diseases Antibodies  >465 publications with IL17A and Central Nervous System Diseases
 Hypersensitivity Antibodies  >398 publications with IL17A and Hypersensitivity
 Colitis Antibodies  >255 publications with IL17A and Colitis
 Liver Diseases Antibodies  >143 publications with IL17A and Liver Diseases

Organs/Tissues associated with anti-IL17A antibody

 Organ/Tissue Name  Pubmed Publications
 Mixed Antibodies  >83 publications with IL17A and Mixed
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