Mouse Anti-GSK3A Monoclonal Antibody – Cat# MBS670117

GSK-3 Alpha (GSK3A) Antibody – Mouse Monoclonal

Name: GSK3A Antibody; Monoclonal; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS670117
Price: 485 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS670117

MBS670117 is an antibody targeting GSK3A. Also known as Mouse Anti-GSK-3a-UNLB. Host: Mouse. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

GSK-3 alpha (GSK3A), Monoclonal Antibody

Full Product Name

Mouse Anti-GSK-3a-UNLB

Product Gene Name

anti-GSK3A antibody

Product Synonym Names

Mouse Anti-GSK-3a - Purified, Unlabeled Antibody; Mouse Anti-GSK-3 alpha

Clonality

Monoclonal

Isotype

Mouse IgG2a

Clone Number

SBGSK3 alpha 2

Host

Mouse

Form/Format

Purified (UNLB) Antibody

Specificity

Human, mouse and rat GSK-3 alpha
Glycogen synthase kinase-3 (GSK-3) is a protein serine kinase that phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK-3 and subsequently inhibits GSK-3 acutely leading to the stimulation of glycogen synthesis. GSK-3 signaling is performed by two isoforms, GSK-3 alpha and GSK-3 beta. The two isoforms share 97% sequence similarity within their catalytic domains. GSK-3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility.

Preparation and Storage

The purified antibody (UNLB) is supplied as 0.1 mg purified immunoglobulin in 0.2 mL of 100 mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. Store at 2- 8 degree C.
The horseradish peroxidase (HRP) conjugate is supplied as 1.0 mL of stock solution in 50% glycerol/50% PBS, pH 7.4. No preservative added. Store at 2-8 degree C or long-term at -20 degree C.
Protect conjugated forms from light. Reagents are stable for the period shown on the label if stored as directed.

Molecular Weight

50,981 Da

Chromosome Location

Chromosome: 19; NC_000019.9 (42734338..42746736, complement). Location: 19q13.2

OMIM

606784

3D Structure

ModBase 3D Structure for P49840

Characterization

To insure lot-to-lot consistency, each batch of product is tested by western blotting to conform with the characteristics of a standard reference reagent.

Applications Tested/Suitable for anti-GSK3A antibody

Western Blot

Other Notes

Small volumes of anti-GSK3A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GSK3A. It may not necessarily be applicable to this product.

NCBI GI #

49574532

NCBI GeneID

2931

NCBI Accession #

NP_063937.2

UniProt Primary Accession #

P49840

UniProt Secondary Accession #

O14959

UniProt Related Accession #

P49840; Q68D16

GenBank Nucleotide #

NM_019884.2

NCBI Official Full Name

glycogen synthase kinase-3 alpha

NCBI Official Synonym Full Names

glycogen synthase kinase 3 alpha

NCBI Official Symbol

GSK3A

NCBI Official Synonym Symbols

DKFZp686D0638

UniProt Protein Name

Glycogen synthase kinase-3 alpha

Protein Family

Glycogen synthase kinase

UniProt Gene Name

GSK3A

UniProt Entry Name

GSK3A_HUMAN

NCBI Protein Information

glycogen synthase kinase-3 alpha; GSK-3 alpha; OTTHUMP00000198366; OTTHUMP00000198367; OTTHUMP00000198368

NCBI Summary for GSK3A

Glycogen synthase kinase 3-alpha (GSK3A; EC {2.7.1.37}) is a multifunctional protein serine kinase, homologous to Drosophila 'shaggy' (zeste-white3) and implicated in the control of several regulatory proteins including glycogen synthase (see GYS1, {138570}) and transcription factors (e.g., JUN, {165160}). It also plays a role in the WNT ({164820}) and PI3K (see PIK3CG, {601232}) signaling pathways (see review by {1:Ali et al. (2001)}).[supplied by OMIM]

UniProt Comments for GSK3A

Function: Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN

Catalytic activity: ATP + [tau protein] = ADP + [tau protein] phosphate.

Subunit structure: Monomer. Interacts with ARRB2

Sequence similarities: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.Contains 1 protein kinase domain.

Research Articles on GSK3A

1. Data show that the effects of PI3K-Akt signalling on IL-10 responses were mediated at least in part by GSK3.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GSK3A antibody

Reference Product	PubMed Publications
SGK3 antibody	>1 publications with GSK3A and SGK3
SGK1 antibody	>1 publications with GSK3A and SGK1
AKT1 antibody	>1 publications with GSK3A and AKT1

Pathways associated with anti-GSK3A antibody

Products by Pathway	Pathway Diagram
AKT Phosphorylates Targets In The Cytosol Pathway antibodies	AKT Phosphorylates Targets In The Cytosol Pathway Diagram
Activation Of Chaperones By IRE1alpha Pathway antibodies	Activation Of Chaperones By IRE1alpha Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class I PI3K Signaling Events Mediated By Akt Pathway antibodies	Class I PI3K Signaling Events Mediated By Akt Pathway Diagram
Diabetes Pathways antibodies	Diabetes Pathways Diagram
Downstream Signaling Of Activated FGFR Pathway antibodies	Downstream Signaling Of Activated FGFR Pathway Diagram
FOXM1 Transcription Factor Network Pathway antibodies	FOXM1 Transcription Factor Network Pathway Diagram
Glycogen Metabolism Pathway antibodies	Glycogen Metabolism Pathway Diagram

Diseases associated with anti-GSK3A antibody

Disease Name	Pubmed Publications
Fibrosis Antibodies	>2 publications with GSK3A and Fibrosis
Mental Disorders Antibodies	>2 publications with GSK3A and Mental Disorders
Cardiomegaly Antibodies	>1 publications with GSK3A and Cardiomegaly
Cardiovascular Diseases Antibodies	>1 publications with GSK3A and Cardiovascular Diseases
Intestinal Diseases Antibodies	>1 publications with GSK3A and Intestinal Diseases
Neoplasms Antibodies	>1 publications with GSK3A and Neoplasms
Adenoma Antibodies	>1 publications with GSK3A and Adenoma
Neurodegenerative Diseases Antibodies	>1 publications with GSK3A and Neurodegenerative Diseases
Dementia Antibodies	>1 publications with GSK3A and Dementia
Adenocarcinoma Antibodies	>1 publications with GSK3A and Adenocarcinoma

Organs/Tissues associated with anti-GSK3A antibody

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>3 publications with GSK3A and Muscle
Brain Antibodies	>3 publications with GSK3A and Brain
Heart Antibodies	>2 publications with GSK3A and Heart
Blood Antibodies	>2 publications with GSK3A and Blood
Kidney Antibodies	>1 publications with GSK3A and Kidney
Mammary Gland Antibodies	>1 publications with GSK3A and Mammary Gland
Embryonic Tissue Antibodies	>1 publications with GSK3A and Embryonic Tissue
Ovary Antibodies	>1 publications with GSK3A and Ovary
Connective Tissue Antibodies	>1 publications with GSK3A and Connective Tissue
Liver Antibodies	>1 publications with GSK3A and Liver