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MMP-2 (MMP2) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS670151

MBS670151 is an antibody targeting Mmp2. Also known as Mouse Anti-Human MMP-2-HRP. Reactive in Human. Host: Mouse. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
MMP-2 (Mmp2), Monoclonal Antibody
Full Product Name
Mouse Anti-Human MMP-2-HRP
Product Gene Name
anti-Mmp2 antibody
Product Synonym Names
Mouse Anti-Human MMP-2 - HRP; Mouse Anti-Human MMP-2
Clonality
Monoclonal
Isotype
Mouse IgG1
Clone Number
SB13a
Host
Mouse
Species Reactivity
Human
Form/Format
Horseradish Peroxidase (HRP) Conjugate
Specificity
Human MMP-2; Does not cross react to human MMP-1, MMP-3 or MMP-9
Matrix metalloproteinases (MMPs) are a family of at least 20 structurally related, zinc-containing enzymes that have the ability to breakdown connective tissue. MMP-2 is also known as gelatinase A, 72 kDa gelatinase, type IV collagenase and TBE-1. MMP-2, along with MMP-9, belongs to the gelatinase group of MMP's which have three repeats of a type II fibronectin domain inserted in the catalytic domain. MMP-2 has shown direct and indirect substrate specificity to collagens I, IV, V, VII, X and XIV, gelatin, elastin, laminin-1, laminin-5, myelin basic protein, MMP-1, MMP-9, and MMP-13. 1-15
Preparation and Storage
The purified antibody (UNLB) is supplied as 0.1 mg purified immunoglobulin in 0.2 mL of 100 mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. Store at 2- 8 degree C. • The horseradish peroxidase (HRP) conjugate is supplied as 1.0 mL of stock solution in 50% glycerol/50% PBS, pH 7.4. No preservative added. Store at 2-8 degree C or long-term at -20 degree C. • Reagents are stable for the period shown on the label if stored as directed.
Molecular Weight
3,196 Da
Chromosome Location
Chromosome: 19; NC_005118.2 (15246036..15275061, complement). Location: 19p11
3D Structure
ModBase 3D Structure for Q9JHC2
Immunogen
Recombinant MMP-2
Characterization
To insure lot-to-lot consistency, each batch of product is tested by ELISA to conform with the characteristics of a standard reference reagent.
Applications Tested/Suitable for anti-Mmp2 antibody
ELISA; Immunohistochemistry_PES
Application Notes for anti-Mmp2 antibody
Immunohistochemistry Suggested Dilution: 1:1,000-1:2,000
ELISA Suggested Dilution: 1:1,000-1:4,000

Product References and Citations for anti-Mmp2 antibody

1. Steffensen, B., U.M. Wallon, and C.M. Overall. 1995. J. Biol. Chem. 270:11555.
2. Collier, I.E., S.M. Wilhelm, A.Z. Eisen, B.L. Marmer, G.A. Grant, J.L. Seltzer, A. Kronberger, C. He, E.A. Bauer, and G.L. Goldberg. 1988. J. Biol. Chem. 263:6579.
3. Allan, J.A., A.J. Docherty, P.J. Barker, N.S. Huskisson, J.J. Reynolds, and G. Murphy. 1995. Biochem. J. 309:229.
4. Seltzer, J.L., A.Z. Eisen, E.A. Bauer, N.P. Morris, R.W. Glanville, and R.E. Burgeson. 1989. J. Biol. Chem. 264:3822.
5. Aimes, R.T., and J.P. Quigley. 1995. J. Biol. Chem. 270:5872.
6. Murphy, G., M.I. Cockett, R.V. Ward, and A.J. Docherty. 1991. Biochem. J. 277:277.
7. Welgus, H.G., C.J. Fliszar, J.L. Seltzer, T.M. Schmid, and J.J. Jeffery. 1990. J. Biiol. Chem. 265:13521.
8. Sires, U.I., B. Dublet, E. Aubert-Foucher, M. van der Rest, and G.G. Welgus. 1995. J. Biol. Chem. 270:1062.
9. Senior, R.M., G.L. Griffin, C.J. Fliszar, S.D. Shapiro, G.I. Goldberg, and H.G. Welgus. 1991. J. Biol. Chem. 266:7870.
10. Khan, K.M., G.W. Laurie, T.A. McCaffrey, and D.J. Falcone. 2002. J. Biol. Chem. 277:13778.
11. Giannelli, G., J. Falk-Marzillier, O. Schiraldi, W.G. Stetler-Stevenson, and V. Quaranta. 1997. Science 277:225.
12. Chandler, S., R. Coates, A. Gearing, J. Lury, G. Wells, and E. Bone. 1995. Neurosci. Lett. 201:223.
13. Crabbe, T., J.P. O'Connell, B.J. Smith, and A.J. Docherty. 1994. Biochemistry 33:14419.
14. Fridman, R., M. Toth, D. Pena, and S. Mobashery. 1995. Cancer Res. 55:2548.
15. Knauper, V., H. Will, C. Lopez-Otin, B. Smith, S.J. Atkinson, H. Stanton, R.M. Hembry, and G. Murphy. 1996. J. Biol. Chem. 271:17124.

Other Notes

Small volumes of anti-Mmp2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Mmp2. It may not necessarily be applicable to this product.

NCBI GI #
8050250
NCBI GeneID
81686
UniProt Primary Accession #
Q9JHC2
UniProt Related Accession #
P33436; Q9JHC2
NCBI Official Full Name
MMP-2
NCBI Official Synonym Full Names
matrix metallopeptidase 2
NCBI Official Symbol
Mmp2
NCBI Official Synonym Symbols
Mmp2
UniProt Protein Name
MMP-2
Protein Family
72 kDa type IV collagenase
UniProt Gene Name
Mmp2
UniProt Synonym Gene Names
MMP-2
UniProt Entry Name
Q9JHC2_RAT
NCBI Protein Information
72 kDa type IV collagenase; MMP-2; gelatinase A; 72 kDa gelatinase; matrix metalloproteinase 2; matrix metalloproteinase-2

NCBI Summary for Mmp2

plays important roles in wound healing, angiogenesis, platelet aggregation, and tumor metastasis; mediates the response of the intrinsic glomerular mesangial cell to inflammatory stimuli [RGD]

Research Articles on Mmp2

1. Data show that mmp-2, endothelin B receptor, and NO synthase are essential players in the sustained relaxin vasodilatory pathway.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Mmp2 antibody

 Products by Pathway  Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 GnRH Signaling Pathway antibodies  GnRH Signaling Pathway Diagram
 GnRH Signaling Pathway antibodies  GnRH Signaling Pathway Diagram
 IL-3 Signaling Pathway antibodies  IL-3 Signaling Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Matrix Metalloproteinases Pathway antibodies  Matrix Metalloproteinases Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram

Organs/Tissues associated with anti-Mmp2 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >184 publications with Mmp2 and Muscle
 Lung Antibodies  >147 publications with Mmp2 and Lung
 Artery Antibodies  >131 publications with Mmp2 and Artery
 Heart Antibodies  >110 publications with Mmp2 and Heart
 Brain Antibodies  >104 publications with Mmp2 and Brain
 Connective Tissue Antibodies  >69 publications with Mmp2 and Connective Tissue
 Embryonic Tissue Antibodies  >66 publications with Mmp2 and Embryonic Tissue
 Eye Antibodies  >50 publications with Mmp2 and Eye
 Prostate Antibodies  >43 publications with Mmp2 and Prostate
 Placenta Antibodies  >35 publications with Mmp2 and Placenta
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