Il-21 (IL21) Antibody – Mouse Monoclonal

This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Function: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG1 and IgG3 in B-cells

By similarity. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. Ref.1 Ref.6

Subcellular location: Secreted Ref.1.

Tissue specificity: Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. Ref.1

Sequence similarities: Belongs to the IL-15/IL-21 family.

Sequence caution: The sequence AAG29348.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH66258.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH66259.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH66260.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH66261.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH66262.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH69124.1 differs from that shown. Reason: Erroneous initiation. The sequence AAU88182.1 differs from that shown. Reason: Erroneous initiation. The sequence ABG36529.1 differs from that shown. Reason: Erroneous initiation.