Mouse Anti-TRAIL Monoclonal Antibody – Cat# MBS670328

TRAIL Antibody – Mouse Monoclonal

Name: TRAIL Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS670328
Price: 405 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS670328

MBS670328 is an antibody targeting TRAIL. Also known as Mouse Anti-Human TRAIL-UNLB. Reactive in Human. Host: Mouse. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

TRAIL, Monoclonal Antibody

Full Product Name

Mouse Anti-Human TRAIL-UNLB

Product Synonym Names

Mouse anti-Human TRAIL

Clonality

Monoclonal

Isotype

IgG2b

Clone Number

SB91a

Host

Mouse

Species Reactivity

Human

Form/Format

Purified (UNLB) Antibody

Specificity

Reacts with Human TRAIL
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family of cytokines. This type II transmembrane protein is expressed by several cytotoxic immune cells, including natural killer cells and activated T cells, and is selective for tumorigenic and virally infected cells2,3. TRAIL can bind to DR4 and DR5 receptors on target cells which facilitates recruitment of numerous signaling proteins to form a death-inducing signaling complex. This signaling complex is then believed to propagate the apoptotic signal through the recruitment and activation of Caspase-84,5.
Numerous studies have identified TRAIL as a potent apoptotic factor in a variety of human cancer cell lines, but this cytokine does not appear to affect normal cell lines6. Therefore, the selectivity and anti-tumorigenic properties of TRAIL make it an intriguing and potentially therapeutic agent in the treatment of cancer.

Preparation and Storage

The purified (UNLB) antibody is supplied as 0.5mg purified immunoglobulin in 1.0mL of 100mM borate buffered saline, pH 8.0; store at 2-8 degree C.
Reagents are stable for the period shown on the label if stored as directed.

Immunogen

Full Length Recombinant Human TRAIL

Characterization

To ensure acceptable performance, each batch of product is tested by ELISA to conform to characteristics of a standard reference reagent.

Applications Tested/Suitable for anti-TRAIL antibody

ELISA

Application Notes for anti-TRAIL antibody

ELISA: 0.1 - 1.0ug/mL

Product References and Citations for anti-TRAIL antibody

1) Zamai, L. et al. (1998). J. Exp. Med. 188:2375-80.
3) Jin, Z. and El-Deiry, W.S. (2006). Mol. Cell. Biol. 26:8136-48.
4) Thorburn, A. (2004). Cell. Sign. 16:139-44.
5) Micheau, O. and Tschopp, J. (2003). Cell. 114:181-90.
6) Nagane, M. et al. (2001). Apop. 6:191-7.

Other Notes

Small volumes of anti-TRAIL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TRAIL. It may not necessarily be applicable to this product.

Protein Family

Tumor necrosis factor ligand superfamily

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.