Mouse Anti-IL31 Monoclonal Antibody – Cat# MBS670350

Il-31 (IL31) Antibody – Mouse Monoclonal

Name: IL31 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS670350
Price: 320 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS670350

MBS670350 is an antibody targeting IL31. Also known as Mouse Anti-Human IL-31-UNLB. Reactive in Human. Host: Mouse. More details

$320 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

IL-31 (IL31), Monoclonal Antibody

Full Product Name

Mouse Anti-Human IL-31-UNLB

Product Gene Name

anti-IL31 antibody

Product Synonym Names

Mouse anti-Human Interleukin-31 (IL-31)

Clonality

Monoclonal

Isotype

IgG2b

Clone Number

SB118b1

Host

Mouse

Species Reactivity

Human

Form/Format

Purified (UNLB) Antibody

Specificity

Reacts with native and recombinant human IL-311
Interleukin-31 (IL-31) is a 24kD alpha-helical protein and a member of the IL-6 family of cytokines that is preferentially expressed by CD4+ T cells2. This cytokine elicits its response by binding to a heterodimeric complex consisting of a gp130-like receptor chain and the oncostatin M receptor subunit. On target cells which include a broad range of immune and non-immune cells, IL-31 binding can induce activation of the Jak/STAT, AKT and MAPK signaling pathways. Due to the ubiquitous expression of its receptor complex, IL-31 has numerous physiological roles that include regulating hematopoiesis and immune response3,4. Over-expression has been linked chronic inflammatory states such as dermatitis, pruritus, airway hypersensitivity and inflammatory bowel disease5-7.

Preparation and Storage

The purified (UNLB) antibody is supplied as 0.1mg purified immunoglobulin in 0.1mL of 100 mM borate buffered saline, pH 8.0; store at 2-8 degree C.

Molecular Weight

18,205 Da

Chromosome Location

Chromosome: 12; NC_000012.11 (122656577..122658746, complement). Location: 12q24.31

OMIM

609509

3D Structure

ModBase 3D Structure for Q6EBC2

Immunogen

Recombinant human IL-31

Characterization

To ensure acceptable performance, each batch of product is tested by ELISA to conform to characteristics of a standard reference reagent.

Applications Tested/Suitable for anti-IL31 antibody

ELISA

Application Notes for anti-IL31 antibody

ELISA: 0.1 - 1.0ug

Product References and Citations for anti-IL31 antibody

1) Zhang, Q. et al. (2008). Cyto. Grow. Rev. 19:347-56.
3) Broxmeyer, H.E. et al. (2007). Exp. Hematol. 35:78-86.
4) Perrigoue, J.G. et al. (2007). J. Exp. Med. 204:481-7.
5) Sonkoly, E. et al. (2006). J. All. Clin. Immunol. 117:411-7.
6) Dillon, S.R. et al. (2004). Nat. Immunol. 5:752-60.
7) Dambacher, J. et al. (2007). Gut. 56:1257-65.

Other Notes

Small volumes of anti-IL31 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IL31. It may not necessarily be applicable to this product.

NCBI GI #

62122911

NCBI GeneID

386653

NCBI Accession #

NP_001014358.1

UniProt Primary Accession #

Q6EBC2

UniProt Secondary Accession #

A2RUQ1

UniProt Related Accession #

Q6EBC2

GenBank Nucleotide #

NM_001014336.1

NCBI Official Full Name

interleukin-31

NCBI Official Synonym Full Names

interleukin 31

NCBI Official Symbol

IL31

NCBI Official Synonym Symbols

IL-31

UniProt Protein Name

Interleukin-31

Protein Family

Interleukin

UniProt Gene Name

IL31

UniProt Synonym Gene Names

IL-31

UniProt Entry Name

IL31_HUMAN

NCBI Protein Information

interleukin-31

NCBI Summary for IL31

IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM, Mar 2008]

UniProt Comments for IL31

Function: Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. IL31 may function in skin immunity. Ref.1

Subcellular location: Secreted

Probable.

Tissue specificity: Detected at low levels in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small intestine and trachea. Ref.1

Induction: Up-regulated in skin homing T-cells of patients with atopic dermatitis (AD) and in activated circulating T-cells. Up-regulated in lesional biopsies of patients with allergic contact dermatitis (ACD). Ref.3 Ref.4

Research Articles on IL31

1. hypothesize that an altered regulation of IL-31 gene expression influence clinical course of AD. The available published data and our results lend support to an important role of IL-31 gene polymorphism in AD pathogenesis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IL31 antibody

Reference Product	PubMed Publications
IL31RA antibody	>12 publications with IL31 and IL31RA
OSMR antibody	>8 publications with IL31 and OSMR
IL6ST antibody	>1 publications with IL31 and IL6ST

Diseases associated with anti-IL31 antibody

Disease Name	Pubmed Publications
Dermatitis, Atopic Antibodies	>35 publications with IL31 and Dermatitis, Atopic
Inflammation Antibodies	>18 publications with IL31 and Inflammation
Brain Diseases Antibodies	>3 publications with IL31 and Brain Diseases
Autoimmune Diseases Antibodies	>2 publications with IL31 and Autoimmune Diseases
Necrosis Antibodies	>2 publications with IL31 and Necrosis
Movement Disorders Antibodies	>1 publications with IL31 and Movement Disorders
Hypersensitivity, Delayed Antibodies	>1 publications with IL31 and Hypersensitivity, Delayed