Cd49d/VLA-4 Antibody – Mouse

CD49d, a member of the integrin family of extracellular matrix and cell adhesion molecules, is the integrin ?4 chain. CD49d associates noncovalently with CD29, the integrin ?1 subunit, to form the ?4?1 very late antigen-4 (VLA-4) heterodimer. Integrin ?4 can also associate with integrin ?7 to form the ?4?7 heterodimer. It is expressed on most leukocytes with the possible exception of neutrophils. VLA-4 mediates leukocyte binding to CD106 (VCAM-1) and is involved in the migration of leukocytes from blood to tissue at sites of inflammation. VLA-4 can also provide a costimulatory signal to T cells for activation and proliferation. The ?4?7 integrin heterodimer is expressed on a small subpopulation of thymocytes, most lymph node T and B lymphocytes, NK cells, and eosinophils. Integrin ?4?7 also binds to fibronectin and VCAM-1

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Small volumes of anti-CD49d/VLA-4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS670394 is an antibody targeting CD49d/VLA-4. Also known as Mouse Anti-Human CD49d/VLA-4-FITC. Reactive in Human. Host: Mouse.