CD44 Antibody – Mouse

CD44, also known as phagocytic glycoprotein-1 (Pgp-1), exists as a large number of different isoforms resulting from alternative RNA splicing. The major isoform expressed on lymphocytes, myeloid cells, and erythrocytes is a glycosylated type I transmembrane protein. Other variable isoforms containing glycosaminoglycans have molecular weights ranging from 110 to 250 kDa and are widely expressed on hematopoietic and non-hematopoietic cells. CD44 contributes to the adhesion of leukocytes to endothelial cells, stromal cells, and the extracellular matrix. It also plays a functional role in cell migration, lymphocyte homing, and adhesion during hematopoiesis and lymphocyte activation.

1. Ellis PA, Hart DN, Colls BM, Nimmo JC, MacDonald JE, Angus HB. Hodgkin's cells express a novel pattern of adhesion molecules. Clin Exp Immunol. 1992;90:117-23. (IHC-FS)
2. Krajewski AS, Howie S, O'Grady J, Biddlestone LR, Bellamy CO. Immunohistochemical staining of paraffin sections of lymphoid and epithelial tissues with workshop adhesion structure subpanel 10 (CD44) mAb. In: Schlossman SF, Boumsell L, Gilks W, Harlan JM, Kishimoto T, Morimoto C, et al, editors. Leukocyte Typing V: White Cell Differentiation Antigens. Oxford: Oxford University Press; 1995. p. 1740-2. (IHC-PS)
3. Anwar F, Wood BL. CD44H and CD44V6 expression in different subtypes of Hodgkin lymphoma. Mod Pathol. 2000;13:1121-7. (IHC-PS)
4. Štefanová I, Hilgert I, Bažil V, Angelisová P, Ho?ejší V. Reactivity of the non-lineage/NK panel antibodies with purified antigens CD45, CD43, CD44, and CD18, and three 'novel' antigens MEM-43, MEM-53, and MEM-102. In: Knapp W, Dörken B, Gilks WR, Rieber EP, Schmidt RE, Stein H, et al, editors. Leukocyte Typing IV: White Cell Differentiation Antigens. Oxford: Oxford University Press; 1989. p. 678-80. (WB)
5. Fukuda Y, Kurihara N, Imoto I, Yasui K, Yoshida M, Yanagihara K, et al. CD44 is a potential target of amplification within the 11p13 amplicon detected in gastric cancer cell lines. Genes Chromosomes Cancer. 2000;29:315-24. (WB, ICC)
6. Mathieu S, Gerolami R, Luis J, Carmona S, Kol O, Crescence L, et al. Introducing alpha(1,2)-linked fucose into hepatocarcinoma cells inhibits vasculogenesis and tumor growth. Int J Cancer. 2007;121:1680-9. (ICC)
7. Mackay CR, Maddox JF, Wijffels GL, Mackay IR, Walker ID. Characterization of a 95,000 molecule on sheep leucocytes homologous to murine Pgp-1 and human CD44. Immunology. 1988;65:93-9. (IP)
8. Stamenkovic I, Aruffo A, Amiot M, Seed B. The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells. EMBO J. 1991;10:343-8. (IP, FC)
9. Bartolazzi A, Jackson D, Bennett K, Aruffo A, Dickinson R, Shields J, et al. Regulation of growth and dissemination of a human lymphoma by CD44 splice variants. J Cell Sci. 1995;108:1723-33. (IP, Depletion, FC)
10. Ruile P, Rank G, Rieber EP. mAb inhibiting the adherence of germinal centre B lymphocytes to follicular dendritic. In: Schlossman SF, Boumsell L, Gilks W, Harlan JM, Kishimoto T, Morimoto C, et al, editors. Leukocyte Typing V: White Cell Differentiation Antigens. Oxford: Oxford University Press; 1995. p. 1576-7. (Adhesion, Block)
11. Denning SM, Telen MJ, Hale LP, Liao HX, Haynes BF. CD44 and CD44R cluster report. In: Schlossman SF, Boumsell L, Gilks W, Harlan JM, Kishimoto T, Morimoto C, et al, editors. Leukocyte Typing V: White Cell Differentiation Antigens. Oxford: Oxford University Press; 1995. p. 1713-9. (Activ)
12. Takahashi K, Eto H, Tanabe KK. Involvement of CD44 in matrix metalloproteinase-2 regulation in human melanoma cells. Int J Cancer. 1999;80:387-95. (WB, Adhesion, Activ)
13. Murray D, Morrin M, McDonnell S. Increased invasion and expression of MMP-9 in human colorectal cell lines by a CD44-dependent mechanism. Anticancer Res. 2004;24:489-94. (Activ)
14. Chapman JR, Taylor CJ, Carter NP, Morris PJ. Comparison of non-lineage antibodies with cytotoxic autoreactive antibodies in haemodialysis patients. In: McMichael AJ, Beverley PC, Cobbold S, Crumpton MJ, Gilks W, Gotch FM, et al, editors. Leukocyte Typing III: White Cell Differentiation Antigens. Oxford: Oxford University Press; 1987. p. 826-8. (CMDC)
15. Dalchau R, Flanagan BF, Allen AK, Daar AS, Fabre JW. Chemical composition and tissue distribution of the human CD44 glycoprotein. In: Knapp W, Dörken B, Gilks WR, Rieber EP, Schmidt RE, Stein H, et al, editors. Leukocyte Typing IV: White Cell Differentiation Antigens. Oxford: Oxford University Press; 1989. p. 622-5. (Purification, FC)

Small volumes of anti-CD44 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS670608 is an antibody targeting CD44. Also known as Mouse Anti-Human CD44-LE/AF. Host: Mouse.