CD1.1 Antibody – Mouse

CD1 molecules, like MHC I and II, play an important role in the immune system by presenting lipid, glycolipid and lipopeptide antigen to T and NKT cells. The chicken CD1 gene is located in the chicken MHC B locus and has an important implication for the primordial MHC gene evolution. Two proteins have been identified - CD1.1 and CD1.2. Analysis of RNA from blood cells showed that both genes are expressed in Bu-1 cells and CD8alpha cells. CD1.2 is expressed in TCRgammadelta cells but is nearly undetectable in TCRalphabeta. The monoclonal antibody CB3 antibody can identify cells of the B cell lineage and recognizes CD1.1 but not CD1.2 on the surface of transfected mammalian cells.

1. Pickel JM, Chen CH, Cooper MD. An avian B-lymphocyte protein associated with beta2-microglobulin. Immunogenetics. 1990;32:1-7. (Immunogen, FC, IHC-FS, ICC, IP)
2. Salomonsen J, Sørensen MR, Marston DA, Rogers SL, Collen T, van Hateren A, et al. Two CD1 genes map to the chicken MHC, indicating that CD1 genes are ancient and likely to have been present in the primordial MHC. Proc Natl Acad Sci USA. 2005;102:8668-73. (FC)
3. Wu Z, Rothwell L, Young JR, Kaufman J, Butter C, Kaiser P. Generation and characterization of chicken bone marrow-derived dendritic cells. Immunology. 2009;129:133-45. (FC)

Small volumes of anti-CD1.1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS670622 is an antibody targeting CD1.1. Also known as Mouse Anti-Chicken CD1.1-FITC. Host: Mouse.