Rat Anti-ATP6V1B2 Monoclonal Antibody – Cat# MBS673218

Cd11b/Mac-1 (ATP6V1B2) Antibody – Rat Monoclonal

Name: ATP6V1B2 Antibody; Monoclonal; Rat; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS673218
Price: 300 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS673218

CD11b, the integrin alphaM subunit, combines with CD18, the integrin B2 subunit, to form the integrin Mac-1, also known as complement receptor 3 (CR3), which mediates adhesion to C3bi and ICAM-1/CD54. Mac-1 is expressed at varying levels on granulocytes,… More details

$300 / 0.5 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CD11b/Mac-1 (ATP6V1B2), Monoclonal Antibody

Full Product Name

Rat Anti-Mouse CD11b/Mac-1a-UNLB

Product Gene Name

anti-ATP6V1B2 antibody

Product Synonym Names

Rat Anti-Mouse CD11b/Mac-1a - Purified, Unlabeled Antibody; Rat Anti-Mouse CD11b/Mac-1

Clonality

Monoclonal

Isotype

Rat (Dark Agouti) IgG_2bkappa

Clone Number

M1/70

Host

Rat

Species Reactivity

Mouse

Form/Format

Purified (UNLB) Antibody

Specificity

Mouse/Human/Rhesus/Baboon/Rabbit CD11b; Mr 170 kDa

Preparation and Storage

Store at 2- 8°C.
The purified (UNLB) antibody is supplied as 0.5 mg of purified immunoglobulin in 1.0 mL of borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added.

Chromosome Location

chromosome: 8; Location: 8p22-p21

OMIM

606939

3D Structure

ModBase 3D Structure for P21281

Immunogen

C57BL/10 mouse splenic T cells and concanavaline A-activated C57BL/10 splenocytes

Applications Tested/Suitable for anti-ATP6V1B2 antibody

Flow Cytometry

Application Notes for anti-ATP6V1B2 antibody

Flow Cytometry Suggested Dilution: Purfied (UNLB) antibody <1 ug/10⁶ cells

Product References and Citations for anti-ATP6V1B2 antibody

1. Springer, T.A., G. Galfre. D.S. Secher, and C. Milstein. 1978. Eur. J. Immunol. 8:539.
2. Springer, T., G. Galfre, D.S. Secher, and C. Milstein. 1979. Eur. J. Immunol. 9:301.
3. Springer, T.A., D. Davignon, M.-K. Ho, K. Kurzinger, E. Martz, and F. Sanchez-Madrid. 1982. Immunol. Rev. 68:171.
4. Beller, D.I., T.A. Springer, R.D. Schreiber. 1982. J. Exp. Med. 156:1000.
5. Sanchez-Madrid, F., P. Simon, S. Thompson, and T.A. Springer. 1983. J. Exp. Med. 158:586.
6. Lub, M., Y. van Kooyk, and C.J. Figdor. 1996. J. Leukoc. Biol. 59:648.
7. Kantor, A.B., A. M. Stall, S. Adams, L.A. Herzenberg, and L.A. Herzenberg. 1992. Proc. Natl. Acad. Sci. USA 89:3320.
8. Ault, K.A., and T.A. Springer. 1981. J. Immunol. 126:359.
9. Gresham, H.D., I.L. Graham, D.C. Anderson, and E.J. Brown. 1991. J. Clin. Invest. 88:588.
10. Springer, T.A. 1994. Cell 76:310.
11. Flotte, T.J., T.A. Springer, and G. Thorbecke. 1983. Am. J. Pathol. 111:112.
12. Gyetko, M.R., S. Sud, T. Kendall, J.A. Fuller, M. W. Newstead, and T.J. Standiford. 2000. J. Immunol. 165:1513.

Other Notes

Small volumes of anti-ATP6V1B2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ATP6V1B2 purchase

MBS673218 is an antibody targeting ATP6V1B2. Also known as Rat Anti-Mouse CD11b/Mac-1a-UNLB. Reactive in Mouse. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for ATP6V1B2. It may not necessarily be applicable to this product.

NCBI GI #

124127039

NCBI GeneID

526

UniProt Primary Accession #

P21281

UniProt Secondary Accession #

Q14544; Q15859; Q96IR0; B2R5Z3; D3DSQ5

UniProt Related Accession #

P21281; Q59HF3

NCBI Official Full Name

CD11b

NCBI Official Synonym Full Names

ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2

NCBI Official Symbol

ATP6V1B2

NCBI Official Synonym Symbols

HO57; VATB; VPP3; Vma2; ATP6B2; ATP6B1B2; ATP6V1B2

UniProt Protein Name

V-type proton ATPase subunit B, brain isoform

UniProt Synonym Protein Names

Endomembrane proton pump 58 kDa subunit; HO57; Vacuolar proton pump subunit B 2

Protein Family

V-type proton ATPase

UniProt Gene Name

ATP6V1B2

UniProt Synonym Gene Names

ATP6B2; VPP3

UniProt Entry Name

VATB2_HUMAN

NCBI Protein Information

V-type proton ATPase subunit B, brain isoform; V-ATPase B2 subunit; V-ATPase subunit B 2; vacuolar proton pump subunit B 2; H+ transporting two-sector ATPase; vacuolar H+-ATPase 56,000 subunit; endomembrane proton pump 58 kDa subunit

NCBI Summary for ATP6V1B2

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts. [provided by RefSeq]

UniProt Comments for ATP6V1B2

Function: Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Subunit structure: V-ATPase is an heteromultimeric enzyme composed of a peripheral catalytic V1 complex (main components: subunits A, B, C, D, E, and F) attached to an integral membrane V0 proton pore complex (main component: the proteolipid protein).

Subcellular location: Endomembrane system; Peripheral membrane protein. Melanosome. Note: Endomembrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Ref.8 Ref.9

Sequence similarities: Belongs to the ATPase alpha/beta chains family.

Research Articles on ATP6V1B2

1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ATP6V1B2 antibody

Products by Pathway	Pathway Diagram
Collecting Duct Acid Secretion Pathway antibodies	Collecting Duct Acid Secretion Pathway Diagram
Collecting Duct Acid Secretion Pathway antibodies	Collecting Duct Acid Secretion Pathway Diagram
Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway antibodies	Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway Diagram
Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway antibodies	Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway Diagram
Insulin Receptor Recycling Pathway antibodies	Insulin Receptor Recycling Pathway Diagram
Iron Uptake And Transport Pathway antibodies	Iron Uptake And Transport Pathway Diagram
Oxidative Phosphorylation Pathway antibodies	Oxidative Phosphorylation Pathway Diagram
Oxidative Phosphorylation Pathway antibodies	Oxidative Phosphorylation Pathway Diagram
Phagosome Pathway antibodies	Phagosome Pathway Diagram
Phagosome Pathway antibodies	Phagosome Pathway Diagram

Diseases associated with anti-ATP6V1B2 antibody

Disease Name	Pubmed Publications
Mental Disorders Antibodies	>2 publications with ATP6V1B2 and Mental Disorders
Seizures Antibodies	>1 publications with ATP6V1B2 and Seizures
Neurodegenerative Diseases Antibodies	>1 publications with ATP6V1B2 and Neurodegenerative Diseases
Insulin Resistance Antibodies	>1 publications with ATP6V1B2 and Insulin Resistance
Acidosis Antibodies	>1 publications with ATP6V1B2 and Acidosis
Schizophrenia Antibodies	>1 publications with ATP6V1B2 and Schizophrenia
Diabetes Mellitus, Type 2 Antibodies	>1 publications with ATP6V1B2 and Diabetes Mellitus, Type 2

Organs/Tissues associated with anti-ATP6V1B2 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>2 publications with ATP6V1B2 and Blood
Muscle Antibodies	>1 publications with ATP6V1B2 and Muscle
Spleen Antibodies	>1 publications with ATP6V1B2 and Spleen
Nerve Antibodies	>1 publications with ATP6V1B2 and Nerve
Heart Antibodies	>1 publications with ATP6V1B2 and Heart
Kidney Antibodies	>1 publications with ATP6V1B2 and Kidney
Pancreas Antibodies	>1 publications with ATP6V1B2 and Pancreas
Brain Antibodies	>1 publications with ATP6V1B2 and Brain