CD54 Antibody – Rat Monoclonal

Monoclonal

IgG_{2b κ}

YN1/1.7.4

Rat

Mouse

The biotin (BIOT) conjugate is supplied as 0.5 mg in 1.0 mL of PBS/NaN3.

Mouse CD54/ICAM-1, Mr 95 kDa
CD54, a member of the immunoglobulin superfamily of cell surface receptors and also known as Intercellular Adhesion Molecule-1 (ICAM-1), is a type I transmembrane glycoprotein that mediates important cell/cell interactions. CD54 is expressed on endothelial cells, dendritic cells, keratinocytes and lymphocytes. Its expression is upregulated by inflammatory mediators such as IFN- gamma, IL-1, TNF- alpha, lipopolysaccharide and phorbol esters. Endothelial CD54 contributes to the extravasation of leukocytes from blood vessels, particularly in areas of inflammation. CD54 on antigen-presenting cells contributes to antigen-specific T-cell activation, presumably by enhancing interactions between T cell and antigen-presenting cells. These adhesion reactions are mediated via the binding of CD54 to its major ligands, LFA-1 and Mac-1.

Store at 2-8°C.

Mouse NS-1 cells