CD49b Antibody – Rat Monoclonal

ITGA2: Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Belongs to the integrin alpha chain family.

Protein type: Membrane protein, integral; Receptor, misc.; Cell adhesion; Motility/polarity/chemotaxis

Cellular Component: cell surface; focal adhesion; cell projection; membrane; perinuclear region of cytoplasm; axon; integral to membrane; plasma membrane; nerve terminal; integrin complex; nucleus; external side of plasma membrane

Molecular Function: integrin binding; collagen binding; protein heterodimerization activity; metal ion binding; protein complex binding; laminin binding

Biological Process: focal adhesion formation; positive regulation of cell adhesion; positive regulation of positive chemotaxis; positive regulation of translation; positive regulation of smooth muscle cell proliferation; cell-matrix adhesion; positive regulation of leukocyte migration; positive regulation of collagen binding; positive regulation of collagen biosynthetic process; positive regulation of cell projection organization and biogenesis; positive regulation of smooth muscle cell migration; establishment of protein localization; positive regulation of smooth muscle contraction; cell adhesion; positive regulation of DNA binding; integrin-mediated signaling pathway; substrate-bound cell migration; skin morphogenesis; hypotonic response; cell-substrate adhesion; detection of mechanical stimulus involved in sensory perception of pain; cell adhesion mediated by integrin; positive regulation of phagocytosis, engulfment; positive regulation of transmission of nerve impulse; positive regulation of inflammatory response