CD105 Antibody – Rat Monoclonal

Monoclonal

Rat IgG2a kappa

MJ7/18

Rat

Mouse

Purified (UNLB) Antibody

Mouse endoglin, Mr 90kDa
CD105/endoglin is a disulfide-linked type II transmembrane homodimer that is predominantly expressed on vascular endothelial cells. It is also found on pre-erythroblasts, macrophages and lymphoid and myeloid leukemic cells.2 Both mouse and human CD105 exhibit >70% sequence homology in their cytoplasmic domains with type III transforming growth factor beta (TGF beta) receptor.3 CD105 has been shown to be one of several receptors for the various isoforms of TGF beta, which in turn is one of a family of proteins involved in regulation of cell differentiation, migration of cells and control of the immune response.4

The purified (UNLB) antibody is supplied as 0.5 mg of purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. Store at 2- 8 degree C.
Protect conjugated forms from light. Reagents are stable for the period shown on the label if stored as directed.

Inflamed mouse skin

To ensure lot-to-lot consistency, each batch of monoclonal antibody is tested by immunohistochemical staining and/or flow cytometry to conform to characteristics of a standard reference reagent.