Rat Anti-HLA-DQB1 Monoclonal Antibody – Cat# MBS673640

MHC Class II (HLA-DQB1) Antibody – Rat Monoclonal

Name: HLA-DQB1 Antibody; Monoclonal; Rat; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS673640
Price: 345 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS673640

MBS673640 is an antibody targeting HLA-DQB1. Also known as Rat Anti-Mouse MHC Class II-PE. Reactive in Mouse. Host: Rat. More details

$345 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MHC Class II (HLA-DQB1), Monoclonal Antibody

Full Product Name

Rat Anti-Mouse MHC Class II-PE

Product Gene Name

anti-HLA-DQB1 antibody

Product Synonym Names

Rat Anti-Mouse MHC Class II - Phycoerythrin-Labeled; Rat Anti-Mouse MHC Class II

Clonality

Monoclonal

Isotype

Rat IgG2b

Clone Number

NIMR-4

Host

Rat

Species Reactivity

Mouse

Form/Format

R - phycoerythrin (R - PE) Conjugate

Specificity

MHC Class II molecules
The monoclonal antibody NIMR-4 reacts specifically with a non-polymorphic I-A-encoded epitope on MHC Class II antigens. Class II antigens are predominantly expressed on antigen-presenting cells including B lymphocytes, macrophages, dendritic cells and certain epithelial cells.

Preparation and Storage

The purified (UNLB) antibody is supplied as 0.5 mg of purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. Store at 2- 8 degree C.
The fluorescein (FITC) conjugate is supplied as 0.5 mg in 1.0 mL of PBS/NaN3. Store at 2-8 degree C.
The biotin (BIOT) conjugate is supplied as 0.5 mg in 1.0 mL of PBS/NaN3. Store at 2-8 degree C.
The R-phycoerythrin (R-PE) conjugate is supplied as 0.1 mg in 1.0 mL or 0.2 mg in 2.0 mL of PBS/NaN3 and a stabilizing agent. Store at 2-8 degree C. Do not freeze!
The Spectral Red (SPRD) conjugate is supplied as 0.1 mg in 1.0 mL of PBS/NaN3 and a stabilizing agent. Store at 2-8 degree C. Do not freeze!
The low endotoxin, azide-free (LE/AF) antibody is supplied as 0.5 mg purified immunoglobulin in 1.0 mL of PBS. Aliquot and store at or below -20 degree C.
Protect conjugated forms from light. Aliquot and freeze the low endotoxin, azide-free product at -20 degree C immediately upon receipt. Each reagent is stable for the period shown on the bottle label if stored as directed.

Molecular Weight

26,489 Da

Chromosome Location

Chromosome: 6; NC_000006.11 (32627657..32634466, complement). Location: 6p21.3

3D Structure

ModBase 3D Structure for O19707

Characterization

To ensure lot-to-lot consistency, each batch of product is tested by flow cytometry to conform to characteristics of a standard reference reagent. Representative data are included in this product insert.

Applications Tested/Suitable for anti-HLA-DQB1 antibody

Flow Cytometry

Application Notes for anti-HLA-DQB1 antibody

Research Application(s): Complement-dependent cytotoxicity assays

Flow Cytometry Suggested Dilution: <=0.2 ug/10^6 cells

Product References and Citations for anti-HLA-DQB1 antibody

1. R.M.E. Parkhouse. 1996. Personal communication.

Other Notes

Small volumes of anti-HLA-DQB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for HLA-DQB1. It may not necessarily be applicable to this product.

NCBI GI #

1160938

NCBI GeneID

3119

UniProt Primary Accession #

O19707

UniProt Related Accession #

O19506; O19632; O19707; O19709; O19710; O19711; O19712; O19714; O19715; A0AQY9

NCBI Official Full Name

MHC class II

NCBI Official Synonym Full Names

major histocompatibility complex, class II, DQ beta 1

NCBI Official Symbol

HLA-DQB1

NCBI Official Synonym Symbols

IDDM1; CELIAC1; HLA-DQB

UniProt Protein Name

MHC class II HLA-DQ-beta-1

Protein Family

HLA class II histocompatibility antigen

UniProt Gene Name

HLA-DQB1

UniProt Entry Name

O19707_HUMAN

NCBI Protein Information

HLA class II histocompatibility antigen, DQ beta 1 chain; MHC DQ beta; MHC class2 antigen; OTTHUMP00000029167; OTTHUMP00000178569; OTTHUMP00000178570; OTTHUMP00000178571; lymphocyte antigen; MHC class II antigen DQB1; MHC class II DQ beta chain; MHC class II antigen HLA-DQ-beta-1; MHC class II HLA-DQ beta glycoprotein; major histocompatibility complex class II beta; HLA class II histocompatibility antigen, DQ beta 1 chain-like

NCBI Summary for HLA-DQB1

HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq]

UniProt Comments for HLA-DQB1

Sequence similarities: Contains 1 Ig-like C1-type (immunoglobulin-like) domain. SAAS SAAS014745

Research Articles on HLA-DQB1

1. that DQB1*0604 hz comprised most to all of the positive association with cervical dystonia

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HLA-DQB1 antibody

Reference Product	PubMed Publications
CD4 antibody	>71 publications with HLA-DQB1 and CD4
INS antibody	>25 publications with HLA-DQB1 and INS
HLA-DQA2 antibody	>5 publications with HLA-DQB1 and HLA-DQA2
CD74 antibody	>1 publications with HLA-DQB1 and CD74

Pathways associated with anti-HLA-DQB1 antibody

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Organs/Tissues associated with anti-HLA-DQB1 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>591 publications with HLA-DQB1 and Blood
Pancreas Antibodies	>92 publications with HLA-DQB1 and Pancreas
Skin Antibodies	>71 publications with HLA-DQB1 and Skin
Liver Antibodies	>60 publications with HLA-DQB1 and Liver
Thyroid Antibodies	>47 publications with HLA-DQB1 and Thyroid
Brain Antibodies	>43 publications with HLA-DQB1 and Brain
Eye Antibodies	>41 publications with HLA-DQB1 and Eye
Heart Antibodies	>28 publications with HLA-DQB1 and Heart
Lung Antibodies	>28 publications with HLA-DQB1 and Lung
Intestine Antibodies	>24 publications with HLA-DQB1 and Intestine