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MHC Class II (HLA-DQB1) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS673933

MBS673933 is an antibody targeting HLA-DQB1. Also known as Mouse Anti-Chicken MHC Class II-UNLB. Reactive in Chicken. Host: Mouse. More details

$395 / 0.5 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MHC Class II (HLA-DQB1), Monoclonal Antibody
Full Product Name
Mouse Anti-Chicken MHC Class II-UNLB
Product Gene Name
anti-HLA-DQB1 antibody
Product Synonym Names
Mouse Anti-Chicken MHC Class II - Purified, Unlabeled Antibody; Mouse Anti-Chicken MHC Class II
Clonality
Monoclonal
Isotype
Mouse IgG1 kappa
Clone Number
2G11
Host
Mouse
Species Reactivity
Chicken
Form/Format
Purified (UNLB) Antibody
Specificity
Chicken MHC Class II (B-L) molecules
The chicken major histocompatibility complex (MHC), or B complex, consists of several clusters of highly polymorphic genes. Like their mammalian counterparts, the avian MHC exerts genetic influence over a variety of important biological functions such as immune response, disease resistance, growth and development, aging, and reproduction. Chicken MHC Class II genes, also known as the B-L subregion, of the chicken MHC encode cell surface glycoproteins that are homologous to mammalian Class II antigens. B-L antigens structurally are similar to mammalian Class II molecules in that they are noncovalently bound dimmers of one 32-34 kDa heavy chain and one 27-30 kDa light chain. MHC Class II is primarily expressed on B cells and antigen presenting cells (APCs).1
Preparation and Storage
The purified (UNLB) antibody is supplied as 0.5 mg of purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. Store at 2- 8 degree C.
The fluorescein (FITC) conjugate is supplied as 0.5 mg in 1.0 mL of PBS/NaN3. Store at 2-8 degree C.
The R-phycoerythrin (R-PE) conjugate is supplied as 0.1 mg in 1.0 mL of PBS/NaN3 and a stabilizing agent. Store at 2-8 degree C. Do not freeze!
Protect conjugated forms from light. Each reagent is stable for the period shown on the bottle label if stored as directed.
Molecular Weight
26,489 Da
Chromosome Location
Chromosome: 6; NC_000006.11 (32627657..32634466, complement). Location: 6p21.3
3D Structure
ModBase 3D Structure for O19707
Characterization
To ensure optimal performance, each batch of monoclonal antibody is tested by flow cytometry to conform to characteristics of a standard reference reagent.
Applications Tested/Suitable for anti-HLA-DQB1 antibody
Flow Cytometry; Immunoblot; Immunohistochemistry; Immunoprecipitation
Application Notes for anti-HLA-DQB1 antibody
Flow Cytometry Suggested Dilution: <= 1 ug/10^6 cells

Product References and Citations for anti-HLA-DQB1 antibody

1. Guillemot, F., P. Turmal, D. Charron, M. Le Douarin, and C. Auffray. 1986. J. Immunol. 137:1251.
2. Lawson, S., L. Rothwell, B. Lambrecht, K. Howes, K. Venugopal, and P. Kaiser. 2001. Dev. Comp. Immunol. 25:69.
3. Koritschoner, N.P., J. Madruga, S. Knespel, G. Blendinger, B. Anzinger, A. Otto, M. Zenke, and P. Bartunek. 2001. Cell Growth Differ. 12:563.
4. Katevuo, K., and O. Vainio. 1996. Immunol. 89:419.
5. Madruga, J., N. Koritschoner, S.S. Diebold, S.M. Kurz, and M. Zenke. 1999. J. Cell Sci. 112:1685.
6. Salomonsen, J., D. Dunon, K. Skjodt, D. Thorpe, O. Vainio, and J. Kaufman. 1991. Proc. Natl. Acad. Sci. USA. 88:1359.
7. Kaufman, J., K.Skjoedt, J. Salomonsen, M. Simonsen, L. Du Pasquier, R. Parisot, and P. Riegert. 1990. J. Immunol. 144:2258.

Other Notes

Small volumes of anti-HLA-DQB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for HLA-DQB1. It may not necessarily be applicable to this product.

NCBI GI #
1160938
NCBI GeneID
3119
UniProt Primary Accession #
O19707
UniProt Related Accession #
O19506; O19632; O19707; O19709; O19710; O19711; O19712; O19714; O19715; A0AQY9
NCBI Official Full Name
MHC class II
NCBI Official Synonym Full Names
major histocompatibility complex, class II, DQ beta 1
NCBI Official Symbol
HLA-DQB1
NCBI Official Synonym Symbols
IDDM1; CELIAC1; HLA-DQB
UniProt Protein Name
MHC class II HLA-DQ-beta-1
Protein Family
HLA class II histocompatibility antigen
UniProt Gene Name
HLA-DQB1
UniProt Entry Name
O19707_HUMAN
NCBI Protein Information
HLA class II histocompatibility antigen, DQ beta 1 chain; MHC DQ beta; MHC class2 antigen; OTTHUMP00000029167; OTTHUMP00000178569; OTTHUMP00000178570; OTTHUMP00000178571; lymphocyte antigen; MHC class II antigen DQB1; MHC class II DQ beta chain; MHC class II antigen HLA-DQ-beta-1; MHC class II HLA-DQ beta glycoprotein; major histocompatibility complex class II beta; HLA class II histocompatibility antigen, DQ beta 1 chain-like

NCBI Summary for HLA-DQB1

HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq]
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UniProt Comments for HLA-DQB1

Sequence similarities: Contains 1 Ig-like C1-type (immunoglobulin-like) domain. SAAS SAAS014745

Research Articles on HLA-DQB1

1. that DQB1*0604 hz comprised most to all of the positive association with cervical dystonia

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HLA-DQB1 antibody

 Reference Product  PubMed Publications
 CD4 antibody  >71 publications with HLA-DQB1 and CD4
 INS antibody  >25 publications with HLA-DQB1 and INS
 HLA-DQA2 antibody  >5 publications with HLA-DQB1 and HLA-DQA2
 CD74 antibody  >1 publications with HLA-DQB1 and CD74

Pathways associated with anti-HLA-DQB1 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immunity Signaling Pathway antibodies  Adaptive Immunity Signaling Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram

Organs/Tissues associated with anti-HLA-DQB1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >591 publications with HLA-DQB1 and Blood
 Pancreas Antibodies  >92 publications with HLA-DQB1 and Pancreas
 Skin Antibodies  >71 publications with HLA-DQB1 and Skin
 Liver Antibodies  >60 publications with HLA-DQB1 and Liver
 Thyroid Antibodies  >47 publications with HLA-DQB1 and Thyroid
 Brain Antibodies  >43 publications with HLA-DQB1 and Brain
 Eye Antibodies  >41 publications with HLA-DQB1 and Eye
 Heart Antibodies  >28 publications with HLA-DQB1 and Heart
 Lung Antibodies  >28 publications with HLA-DQB1 and Lung
 Intestine Antibodies  >24 publications with HLA-DQB1 and Intestine
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