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MS4A1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS674125

MBS674125 is an antibody targeting MS4A1. Also known as Mouse Anti-Human CD20-FITC. Reactive in Human. Host: Mouse. More details

$295 / 100 Tests +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD20 (MS4A1), Monoclonal Antibody
Full Product Name
Mouse Anti-Human CD20-FITC
Product Gene Name
anti-MS4A1 antibody
Product Synonym Names
Mouse Anti-Human CD20 - FITC; Mouse Anti-Human CD20
Clonality
Monoclonal
Isotype
Mouse IgG1
Clone Number
B-Ly1
Host
Mouse
Species Reactivity
Human
Form/Format
Fluorescein (FITC) Conjugate
Specificity
Human CD20
CD20 is a 33-37 kDa unglycosylated phosphoprotein. Although not a member of the tetraspanin superfamily of cell surface receptors, it crosses the cell membrane four times. It is expressed on all stages of B cell differentiation except plasma cells. The CD20 molecule is involved in regulation of B cell differentiation, presumably via its reported function as a Ca++ channel subunit.1-4
Preparation and Storage
The purified (UNLB) antibody is supplied as 0.1 mg of purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. Store at 2- 8 degree C.
The fluorescein (FITC) conjugate is supplied as 100 tests in 1.0 mL of PBS/NaN3. Store at 2-8 degree C.
The biotin (BIOT) conjugate is supplied as 100 tests in 1.0 mL of PBS/NaN3. Store at 2-8 degree C.
The R-phycoerythrin (R-PE), and allophycocyanin (APC) conjugates are supplied as 100 tests in 1.0 mL of PBS/NaN3 and a stabilizing agent. Store at 2-8 degree C. Do not freeze!
The Spectral Red (SPRD), R-phycoerythrin-Cyanine 7 (R-PE-CY 7), and allophycocyanin-Cyanine 7 (APC-CY 7) conjugates are supplied as 100 tests in 1.0 mL of PBS/NaN3 and a stabilizing agent. Store at 2-8 degree C. Do not freeze!
Protect conjugated forms from light. Reagents are stable for the period shown on the label if stored as directed.
Molecular Weight
33,056 Da
Chromosome Location
Chromosome: 21; NC_006603.2 (53903583..53913185)
3D Structure
ModBase 3D Structure for Q3C2E2
Characterization
To insure lot to lot consistency, each batch of product is tested by flow cytometry to conform to characteristics of a standard reference reagent.
Applications Tested/Suitable for anti-MS4A1 antibody
Flow Cytometry; Immunoprecipitation
Application Notes for anti-MS4A1 antibody
Research Application(s): In vitro activation of B cells

Flow Cytometry Suggested Dilution: 10 uL/10^6 cells

Product References and Citations for anti-MS4A1 antibody

1. Knapp, W., B. Dorken, W.R. GIlks, E.P. Rieber, R.E. Schmidt, H. Stein, A.E.G.K. Von dem Borne, eds. 1989. Leukocyte Typing IV: White Cell Differentiation Antigens, Oxford University Press, Oxford.
2. Barclay, A.N., M.H. Brown, S.K.A. Law, A.J. McKnight, M.G. Tomlinson, and P.A. van der Merwe, eds. 1997. The Leukocyte Antigens Facts Book, 2nd Edition, CD20 Section, Academic Press, New York, p. 181.
3. Tedder. T.F., and P. Engel. 1994. Immunol. Today 15:450.
4. Tedder, T.F., M. Streuli, S.F. Schlossman, and H. Saito. 1988. Proc. Natl. Acad. Sci. USA 85:208.

Other Notes

Small volumes of anti-MS4A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MS4A1. It may not necessarily be applicable to this product.

NCBI GI #
78183404
NCBI GeneID
485430
UniProt Primary Accession #
Q3C2E2
UniProt Related Accession #
Q3C2E2
NCBI Official Full Name
CD20
NCBI Official Symbol
MS4A1
NCBI Official Synonym Symbols
CD20
UniProt Protein Name
B-lymphocyte antigen CD20
UniProt Synonym Protein Names
Membrane-spanning 4-domains subfamily A member 1
Protein Family
B-lymphocyte antigen
UniProt Gene Name
MS4A1
UniProt Synonym Gene Names
CD20
UniProt Entry Name
CD20_CANFA
NCBI Protein Information
B-lymphocyte antigen CD20; membrane-spanning 4-domains subfamily A member 1

UniProt Comments for MS4A1

Function: This protein may be involved in the regulation of B-cell activation and proliferation

Subcellular location: Membrane; Multi-pass membrane protein

Tissue specificity: Expressed in PBMCs and lymph node from healthy dogs, in B-cells of canine lymphoma, but not in T-cell lymphoma cells and non-T and non-B-cell lymphoma cells. Ref.1

Post-translational modification: Phosphorylated. Might be functionally regulated by protein kinase(s)

Sequence similarities: Belongs to the MS4A family.
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Research Articles on MS4A1

1. This study examined the immunoreactivity of a monoclonal antibody to MUM1/IRF4 and compared it with expression of CD79a and CD20 in 109 plasmacytomas in 107 dogs.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-MS4A1 antibody

 Products by Pathway  Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram

Diseases associated with anti-MS4A1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >2700 publications with MS4A1 and Neoplasms
 Lymphoma Antibodies  >2143 publications with MS4A1 and Lymphoma
 Leukemia Antibodies  >833 publications with MS4A1 and Leukemia
 Autoimmune Diseases Antibodies  >560 publications with MS4A1 and Autoimmune Diseases
 Lymphoma, T-Cell Antibodies  >431 publications with MS4A1 and Lymphoma, T-Cell
 Skin Diseases Antibodies  >326 publications with MS4A1 and Skin Diseases
 Cardiovascular Diseases Antibodies  >303 publications with MS4A1 and Cardiovascular Diseases
 Vascular Diseases Antibodies  >293 publications with MS4A1 and Vascular Diseases
 Inflammation Antibodies  >218 publications with MS4A1 and Inflammation
 Arthritis, Rheumatoid Antibodies  >214 publications with MS4A1 and Arthritis, Rheumatoid

Organs/Tissues associated with anti-MS4A1 antibody

 Organ/Tissue Name  Pubmed Publications
 Artery Antibodies  >36 publications with MS4A1 and Artery
 Lymphoreticular Antibodies  >4 publications with MS4A1 and Lymphoreticular
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