CD36 Antibody – Mouse Monoclonal

The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]

Function: Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic efects. Ref.20 Ref.22

Subunit structure: Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity. Ref.12

Subcellular location: Membrane; Multi-pass membrane protein.

Post-translational modification: N-glycosylated and O-glycosylated with a ratio of 2:1. Ref.8 Ref.14 Ref.15 Ref.16

Polymorphism: Genetic variation in CD36 influences the severity and outcome of malaria infection.

Involvement in disease: Defects in CD36 are the cause of platelet glycoprotein IV deficiency (PG4D)[

MIM:608404]; also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal. Ref.17 Ref.21Genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7 (CHDS7) [

MIM:610938]. Ref.23

Sequence similarities: Belongs to the CD36 family.

Sequence caution: The sequence AAM14636.2 differs from that shown. Reason: Frameshift at position 53.