Pigeon PAPP-A ELISA Kit – Cat# MBS068675

Pregnancy Associated Plasma Protein A (PAPP-A) ELISA Kit for Pigeon

Name: Pigeon PAPP-A ELISA Kit; Pregnancy Associated Plasma Protein A; MyBioSource
Brand: MyBioSource
SKU: MBS068675
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS068675

MBS068675 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Pregnancy Associated Plasma Protein A (PAPP-A) ELISA Kit target analytes in biological samples. The concentration… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

Pregnancy Associated Plasma Protein A (PAPP-A), ELISA Kit

Full Product Name

Pigeon Pregnancy Associated Plasma Protein A ELISA Kit

Product Gene Name

PAPP-A elisa kit

Species Reactivity

Pigeon

Preparation and Storage

Store all reagents at 2-8 degree C

Molecular Weight

180,973 Da

OMIM

176385

3D Structure

ModBase 3D Structure for Q13219

Other Notes

Small volumes of PAPP-A elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PAPP-A. It may not necessarily be applicable to this product.

NCBI GI #

223590248

NCBI GeneID

5069

NCBI Accession #

Q13219.3

UniProt Primary Accession #

Q13219

UniProt Secondary Accession #

Q08371; Q68G52; Q9UDK7; B1AMF9

UniProt Related Accession #

Q13219

NCBI Official Full Name

Pappalysin-1

NCBI Official Synonym Full Names

pregnancy-associated plasma protein A, pappalysin 1

NCBI Official Symbol

PAPPA

NCBI Official Synonym Symbols

PAPA; DIPLA1; PAPP-A; PAPPA1; ASBABP2; IGFBP-4ase

UniProt Protein Name

Pappalysin-1

UniProt Synonym Protein Names

Insulin-like growth factor-dependent IGF-binding protein 4 protease; IGF-dependent IGFBP-4 protease; IGFBP-4ase; Pregnancy-associated plasma protein A

Protein Family

Pappalysin

UniProt Gene Name

PAPPA

UniProt Synonym Gene Names

IGF-dependent IGFBP-4 protease; IGFBP-4ase; PAPP-A

UniProt Entry Name

PAPP1_HUMAN

NCBI Protein Information

pappalysin-1; IGF-dependent IGFBP-4 protease; aspecific BCL2 ARE-binding protein 2; pregnacy-associated plasma protein A; differentially placenta 1 expressed protein; insulin-like growth factor-dependent IGF binding protein-4 protease; insulin-like growth factor-dependent IGF-binding protein 4 protease

NCBI Summary for PAPP-A

This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. [provided by RefSeq, Jul 2008]

UniProt Comments for PAPP-A

PAPPA: Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. Belongs to the peptidase M43B family.

Protein type: Secreted; EC 3.4.24.79; Protease; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9q33.2

Cellular Component: membrane; extracellular region

Molecular Function: metallopeptidase activity; zinc ion binding; metalloendopeptidase activity

Biological Process: cellular protein metabolic process; female pregnancy; cell differentiation; proteolysis

Research Articles on PAPP-A

1. PAPPA can be used as a novel biomarker for the diagnosis of sepsis-related myocardial dysfunction and the prediction of outcomes in critically ill patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PAPP-A elisa kit

Reference Product	PubMed Publications
IGFBP4 elisa kit	>8 publications with PAPP-A and IGFBP4
IGF1 elisa kit	>5 publications with PAPP-A and IGF1
IGF2 elisa kit	>3 publications with PAPP-A and IGF2
IGFBP5 elisa kit	>3 publications with PAPP-A and IGFBP5
PRG2 elisa kit	>1 publications with PAPP-A and PRG2

Pathways associated with PAPP-A elisa kit

Products by Pathway	Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway antibodies	Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway Diagram

Diseases associated with PAPP-A elisa kit

Disease Name	Pubmed Publications
Neoplasms Antibodies	>128 publications with PAPP-A and Neoplasms
Nervous System Diseases Antibodies	>45 publications with PAPP-A and Nervous System Diseases
Heart Diseases Antibodies	>26 publications with PAPP-A and Heart Diseases
Inflammation Antibodies	>26 publications with PAPP-A and Inflammation
Brain Diseases Antibodies	>20 publications with PAPP-A and Brain Diseases
Lung Diseases Antibodies	>19 publications with PAPP-A and Lung Diseases
Necrosis Antibodies	>18 publications with PAPP-A and Necrosis
Uterine Neoplasms Antibodies	>14 publications with PAPP-A and Uterine Neoplasms
Pain Antibodies	>14 publications with PAPP-A and Pain
Hypertension Antibodies	>12 publications with PAPP-A and Hypertension

Organs/Tissues associated with PAPP-A elisa kit

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>63 publications with PAPP-A and Bone
Bone Marrow Antibodies	>42 publications with PAPP-A and Bone Marrow
Vascular Antibodies	>39 publications with PAPP-A and Vascular
Heart Antibodies	>27 publications with PAPP-A and Heart
Eye Antibodies	>23 publications with PAPP-A and Eye
Liver Antibodies	>22 publications with PAPP-A and Liver
Muscle Antibodies	>22 publications with PAPP-A and Muscle
Lung Antibodies	>17 publications with PAPP-A and Lung
Brain Antibodies	>17 publications with PAPP-A and Brain
Skin Antibodies	>14 publications with PAPP-A and Skin