PCPE-1 Antibody – Rat Monoclonal

Procollagen Cendopeptidase enhancers, known as PCPEs or PCOLCEs, are secreted extracellular matrix glycoproteins that consist of two CUB domains and one NTR domain. They are known to stimulate enzymatic cleavage of procollagens IIII by the BMP-1/ tolloid family of metallo-proteases, also known as procollagen Cproteinases. PCPE1 is expressed primarily by interstitial connective tissues such as tendons, calvaria, and skin. Although BMP1/ tolloid proteinases are involved in processing of multiple extracellular proteins, the enhancer activity of PCPE1 is specific to procollagens since it has no effect on BMP1/ tolloid cleavage of other substrates. It is thought that PCPE1 enhances cleavage of procollagens by binding to the substrate, inducing a conformation change in the substrate, although interaction between PCPE-1 and fulllength BMP-1/ tolloid proteinases has also been reported.

Small volumes of anti-PCPE-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS690005 is an antibody targeting PCPE-1. Also known as Rat Anti-Mouse PCPE-1. Reactive in Mouse. Host: Rat.