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TNFRSF11A Antibody – Rat Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS690024

Receptor activator of NF-kB (RANK), also known as TRANCE receptor, osteoclast differentiation factor receptor (ODFR) and TNFRSF11A, is a member of the TNF receptor superfamily. Human and mouse RANK share 81% amino acid sequence identity in their extracellular… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
TNFRSF11A, Monoclonal Antibody
Full Product Name
Rat Anti-Mouse TNFRSF11A
Product Gene Name
Product Synonym Names
Tnfrsf11a; OFE; ODFR; Rank; Ly109; mRANK; TRANCE-R
Clonality
Monoclonal
Isotype
IgG2
Clone Number
(12G33)
Host
Rat
Species Reactivity
Mouse
Form/Format
Lyophilized
Preparation and Storage
Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.
Molecular Weight
66,621 Da
Chromosome Location
Chromosome: 1; NC_000067.6 (105780723..105847981). Location: 1 E2.1; 1
3D Structure
ModBase 3D Structure for O35305
Reconstitution
Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-TNFRSF11A antibody
Western Blot (WB)

Other Notes

Small volumes of anti-TNFRSF11A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TNFRSF11A purchase

MBS690024 is an antibody targeting TNFRSF11A. Also known as Rat Anti-Mouse TNFRSF11A. Reactive in Mouse. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for TNFRSF11A. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 11A
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 11a
NCBI Official Symbol
Tnfrsf11a
NCBI Official Synonym Symbols
OFE; ODFR; Rank; Ly109; mRANK; TRANCE-R
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 11A
UniProt Synonym Protein Names
Osteoclast differentiation factor receptor; ODFR; Receptor activator of NF-KB
UniProt Gene Name
Tnfrsf11a
UniProt Synonym Gene Names
Rank; ODFR
UniProt Entry Name
TNR11_MOUSE
NCBI Protein Information
tumor necrosis factor receptor superfamily member 11A; receptor activator of NF-KB; receptor activator of NF-kappaB; osteoclast differentiation factor receptor

UniProt Comments for TNFRSF11A

Function: Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells. Ref.3 Ref.4

Subunit structure: Binds to the clefts between the subunits of the TNFSF11 ligand trimer to form a heterohexamer. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6

By similarity. Interacts (via cytoplasmic domain) with GAB2

By similarity. Ref.4

Subcellular location: Membrane; Single-pass type I membrane protein

Potential.

Tissue specificity: Ubiquitous expression with high levels in trabecular bone, thymus, small intestine, lung, brain and kidney. Weakly expressed in spleen and bone marrow.

Sequence similarities: Contains 4 TNFR-Cys repeats.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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