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BMPR1B Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8102879

BMPR1B(bone morphogenetic protein receptor, type IB), also known as ALK6, is a member of the bone morphogenetic protein (BMP) receptor family. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through… More details

$370 / 0.1 mL +1 FREE 8GB USB
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
BMPRIB (BMPR1B), Monoclonal Antibody
Full Product Name
Anti-BMPRIB Antibody, Mouse Monoclonal
Product Gene Name
anti-BMPR1B antibody
Product Synonym Names
ALK-6/BMPR1B Antibody, Mouse MAb; bone morphogenetic protein receptor, type IB; Anti-ALK-6 Antibody; Anti-ALK6 Antibody; Anti-CDw293 Antibody
Clonality
Monoclonal
Isotype
Mouse IgG1
Clone Number
06
Host
Mouse
Species Reactivity
Human
Form/Format
Liquid; 0.2um filtered solution in PBS
Purity/Purification
Protein A
Specificity
Human ALK-6/BMPR1B.
No cross-reactivity in ELISA with Insect cell lysate
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Molecular Weight
60,582 Da
OMIM
112600
3D Structure
ModBase 3D Structure for O00238
Immunogen
Recombinant Human ALK-6/BMPR1B protein
Conjugation
Unconjugated
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human ALK-6/BMPR1B (rh ALK-6/BMPR1B). The IgG fraction of the cell culture supernatant was purified by Protein A affinity.
Applications Tested/Suitable for anti-BMPR1B antibody
ELISA (EIA)
Application Notes for anti-BMPR1B antibody
ELISA: 1:1000-1:2000

Product References and Citations for anti-BMPR1B antibody

Ide H, et al. (1998) Assignment of the BMPR1A and BMPR1B genes to human chromosome 10q22.3 and 4q23--q24 byin situ hybridization and radiation hybrid map ping. Cytogenet. Cell Genet. 81(3-4): 285-6.Mishina Y, et al. (2004) Bone morphogenetic protein type IA receptor signaling regulates postnatal osteoblast function and bone remodeling. J Biol Chem. 279(26): 27560-6.Yoon BS, et al. (2005) Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo. Proc Natl Acad Sci. 102(14): 5062-7.

Other Notes

Small volumes of anti-BMPR1B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BMPR1B purchase

MBS8102879 is an antibody targeting BMPR1B. Also known as Anti-BMPRIB Antibody, Mouse Monoclonal. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for BMPR1B. It may not necessarily be applicable to this product.

NCBI GI #
4502431
NCBI GeneID
658
NCBI Accession #
NP_001194.1
UniProt Primary Accession #
O00238
UniProt Secondary Accession #
P78366; B2R953; B4DSV1
UniProt Related Accession #
O00238
GenBank Nucleotide #
NM_001203.2
NCBI Official Full Name
bone morphogenetic protein receptor type-1B isoform b
NCBI Official Synonym Full Names
bone morphogenetic protein receptor type 1B
NCBI Official Symbol
BMPR1B
NCBI Official Synonym Symbols
ALK6; AMDD; BDA2; ALK-6; BDA1D; CDw293
UniProt Protein Name
Bone morphogenetic protein receptor type-1B
Protein Family
Bone morphogenetic protein receptor
UniProt Gene Name
BMPR1B
UniProt Synonym Gene Names
BMP type-1B receptor; BMPR-1B
UniProt Entry Name
BMR1B_HUMAN
NCBI Protein Information
bone morphogenetic protein receptor type-1B

UniProt Comments for BMPR1B

BMPR1B: a kinase of the STKR family. A type I cell-surface receptor for bone morphogenetic protein. Expressed at ighest level in the prostate. May be upregulated by androgen stimulation in cells which expresses the androgen receptor.

Protein type: Protein kinase, Ser/Thr (receptor); Kinase, protein; EC 2.7.11.30; Membrane protein, integral; Protein kinase, TKL; TKL group; STKR family; Type1 subfamily

Chromosomal Location of Human Ortholog: 4q22-q24

Cellular Component: integral to plasma membrane; plasma membrane; receptor complex

Molecular Function: protein serine/threonine kinase activity; protein binding; transforming growth factor beta receptor activity, type I; metal ion binding; SMAD binding; ATP binding; transmembrane receptor protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity

Biological Process: chondrocyte development; positive regulation of bone mineralization; protein amino acid phosphorylation; limb morphogenesis; BMP signaling pathway; positive regulation of osteoblast differentiation; ovulation cycle; dorsal/ventral pattern formation; eye development; retina development in camera-type eye; proteoglycan biosynthetic process; ovarian cumulus expansion; inflammatory response; positive regulation of cell differentiation; skeletal development; cartilage condensation; retinal ganglion cell axon guidance

Disease: Brachydactyly, Type A2; Chondrodysplasia, Acromesomelic, With Genital Anomalies
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-BMPR1B antibody

 Reference Product  PubMed Publications
 BMPR2 antibody  >113 publications with BMPR1B and BMPR2
 BMP2 antibody  >71 publications with BMPR1B and BMP2
 SMAD1 antibody  >51 publications with BMPR1B and SMAD1
 BMP4 antibody  >49 publications with BMPR1B and BMP4
 BMP7 antibody  >33 publications with BMPR1B and BMP7
 GDF5 antibody  >25 publications with BMPR1B and GDF5
 SMAD5 antibody  >22 publications with BMPR1B and SMAD5
 BMP6 antibody  >21 publications with BMPR1B and BMP6
 SMAD9 antibody  >8 publications with BMPR1B and SMAD9
 SMAD6 antibody  >6 publications with BMPR1B and SMAD6

Pathways associated with anti-BMPR1B antibody

 Products by Pathway  Pathway Diagram
 BMP Signaling Pathway antibodies  BMP Signaling Pathway Diagram
 BMP Signaling Pathway antibodies  BMP Signaling Pathway Diagram
 BMP Signalling And Regulation Pathway antibodies  BMP Signalling And Regulation Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Ovarian Infertility Genes Pathway antibodies  Ovarian Infertility Genes Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By BMP Pathway antibodies  Signaling By BMP Pathway Diagram

Diseases associated with anti-BMPR1B antibody

 Disease Name  Pubmed Publications
 Bone Diseases, Developmental Antibodies  >11 publications with BMPR1B and Bone Diseases, Developmental
 Brachydactyly type A2 Antibodies  >9 publications with BMPR1B and Brachydactyly type A2
 Breast Neoplasms Antibodies  >9 publications with BMPR1B and Breast Neoplasms
 Lung Diseases Antibodies  >8 publications with BMPR1B and Lung Diseases
 Disease Models, Animal Antibodies  >7 publications with BMPR1B and Disease Models, Animal
 Craniofacial Abnormalities Antibodies  >5 publications with BMPR1B and Craniofacial Abnormalities
 Ovarian Diseases Antibodies  >5 publications with BMPR1B and Ovarian Diseases
 Prostatic Diseases Antibodies  >5 publications with BMPR1B and Prostatic Diseases
 Inflammation Antibodies  >5 publications with BMPR1B and Inflammation
 Prostatic Neoplasms Antibodies  >5 publications with BMPR1B and Prostatic Neoplasms

Organs/Tissues associated with anti-BMPR1B antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >238 publications with BMPR1B and Bone
 Ovary Antibodies  >35 publications with BMPR1B and Ovary
 Brain Antibodies  >19 publications with BMPR1B and Brain
 Embryonic Tissue Antibodies  >18 publications with BMPR1B and Embryonic Tissue
 Muscle Antibodies  >15 publications with BMPR1B and Muscle
 Connective Tissue Antibodies  >13 publications with BMPR1B and Connective Tissue
 Nerve Antibodies  >12 publications with BMPR1B and Nerve
 Eye Antibodies  >10 publications with BMPR1B and Eye
 Vascular Antibodies  >10 publications with BMPR1B and Vascular
 Lung Antibodies  >10 publications with BMPR1B and Lung
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