IL-17 receptor Antibody – Mouse Monoclonal

Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014]

Function: Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling. Ref.7 Ref.10

Subunit structure: Forms heterodimers with IL17RE; the heterodimer binds IL17C.

Subcellular location: Isoform 1: Membrane; Single-pass type I membrane protein

By similarity Ref.9. Isoform 2: Secreted Ref.9.

Tissue specificity: Widely expressed. Ref.7

Post-translational modification: Glycosylated. Ref.10

Involvement in disease: Candidiasis, familial, 5 (CANDF5) [MIM:613953]: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.8

Sequence similarities: Contains 1 SEFIR domain.