SCGF Antibody – Mouse Monoclonal

This gene encodes a member of the C-type lectin superfamily. The encoded protein is a secreted sulfated glycoprotein and functions as a growth factor for primitive hematopoietic progenitor cells. An alternative splice variant has been described but its biological nature has not been determined. [provided by RefSeq, Jul 2008]

Function: Stimulates the proliferation and differentiation of hematopoietic precursor cells from various lineages, including erythrocytes, lymphocytes, granulocytes and macrophages. Acts synergistically with other cytokines, including IL-3, GCSF, GMCSF and FLT3 ligand. Suppresses SCF-stimulated erythrocyte proliferation. Ref.7

Subcellular location: Cytoplasm. Secreted Ref.8.

Tissue specificity: Expressed in skeletal tissues including bone marrow, chondrocytes, primary ossification center-associated cells, the perichondrium and periosteum. Lower levels of expression were detected in spleen, thymus, appendix and fetal liver. Ref.1 Ref.2 Ref.7 Ref.8

Developmental stage: In the bone marrow, expression is limited to immature neutrophils. Expression was not detected in circulating mature neutrophils. Ref.8

Post-translational modification: O-glycosylated. Probably sulfated on the O-glycans. Ref.1

Sequence similarities: Contains 1 C-type lectin domain.