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Oncostatin M (OSM) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2003523
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MBS2003523 is an antibody targeting OSM. Also known as Polyclonal Antibody to Oncostatin M (OSM). Reactive in Mouse. Host: Rabbit. More details

$205 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Oncostatin M (OSM), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Oncostatin M (OSM)
Product Gene Name
anti-OSM antibody
Immunogen Sequence
Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG SEF- NRGCSN SSSQLLSQLQ NQANLTGNTE SLLEPYIRLQ NLNTPDLRAA CTQHSVAFPS EDTLRQLSKP HFLSTVYTTL DRVLYQLDAL RQKFL
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
0.46mg/ml (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against OSM. It has been selected for its ability to recognize OSM in immunohistochemical staining and western blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: OSM (MBS2003523)
Immunogen: OSM (MBS2009222)
Matching Pairs
Unconjugated Antibody: OSM (MBS2003523)
APC-CY7 Conjugated Antibody: OSM (MBS2037930)
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Molecular Weight
30,114 Da
3D Structure
ModBase 3D Structure for P53347
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
Recombinant OSM (Asn25~Leu115) with N-terminal His-Tag expressed in E.coli.
Cross Reactivity
Mouse
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2037934
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-OSM antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-OSM antibody
Western blotting: 1:50-400
Immunocytochemistry in formalin fixed cells: 1:50-500
Immunohistochemistry in formalin fixed frozen section: 1:50-500
Immunohistochemistry in paraffin section: 1:10-100
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-OSM antibody

Western Blot: Sample: Recombinant OSM, Mouse.
Rabbit Anti-OSM Polyclonal Antibody – Cat# MBS2003523

Immunohistochemistry (IHC) of anti-OSM antibody

DABstainingonIHC-P.Samples:MouseTissue)
Rabbit Anti-OSM Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2003523

Other Notes

Small volumes of anti-OSM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for OSM. It may not necessarily be applicable to this product.

NCBI GI #
61656173
NCBI GeneID
18413
NCBI Accession #
NP_001013383.1
UniProt Primary Accession #
P53347
UniProt Secondary Accession #
Q3U1Y5; Q5SPX6
UniProt Related Accession #
P53347
GenBank Nucleotide #
NM_001013365.2
NCBI Official Full Name
oncostatin-M
NCBI Official Synonym Full Names
oncostatin M
NCBI Official Symbol
Osm
NCBI Official Synonym Symbols
OncoM
UniProt Protein Name
Oncostatin-M
Protein Family
Oncostatin
UniProt Gene Name
Osm
UniProt Synonym Gene Names
OSM
NCBI Protein Information
oncostatin-M

UniProt Comments for OSM

OSM: Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration. Belongs to the LIF/OSM family.

Protein type: Cytokine; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11 A1|11 2.94 cM

Cellular Component: extracellular region; extracellular space

Molecular Function: cytokine activity; growth factor activity; oncostatin-M receptor binding

Biological Process: behavioral response to pain; immune response; negative regulation of cell proliferation; negative regulation of hormone secretion; negative regulation of meiotic nuclear division; peripheral nervous system development; positive regulation of cell proliferation; positive regulation of MAPK cascade; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tyrosine phosphorylation of STAT protein; regulation of growth; response to heat; tyrosine phosphorylation of STAT protein
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Research Articles on OSM

1. OSM mitigated the proliferation of Th17 cells and decreased the expression of IL-17 and IL-21; it promoted the activation of suppressor of cytokine signaling 3 (SOCS3), STAT3, and STAT5; observations suggest that OSM can inhibit Th17 differentiation by reciprocally controlling SOCS3, STAT3, and STAT5
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-OSM antibody

 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram

Diseases associated with anti-OSM antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >212 publications with OSM and Inflammation
 Necrosis Antibodies  >152 publications with OSM and Necrosis
 Liver Diseases Antibodies  >74 publications with OSM and Liver Diseases
 Disease Models, Animal Antibodies  >70 publications with OSM and Disease Models, Animal
 Kidney Diseases Antibodies  >54 publications with OSM and Kidney Diseases
 Fibrosis Antibodies  >48 publications with OSM and Fibrosis
 Breast Neoplasms Antibodies  >44 publications with OSM and Breast Neoplasms
 Lung Diseases Antibodies  >38 publications with OSM and Lung Diseases
 Neoplasms, Experimental Antibodies  >29 publications with OSM and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >25 publications with OSM and Lung Neoplasms

Organs/Tissues associated with anti-OSM antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >461 publications with OSM and Blood
 Bone Antibodies  >183 publications with OSM and Bone
 Lung Antibodies  >99 publications with OSM and Lung
 Heart Antibodies  >83 publications with OSM and Heart
 Skin Antibodies  >57 publications with OSM and Skin
 Spleen Antibodies  >21 publications with OSM and Spleen
 Lymph Node Antibodies  >20 publications with OSM and Lymph Node
 Thymus Antibodies  >17 publications with OSM and Thymus
 Inner Ear Antibodies  >6 publications with OSM and Inner Ear
 Uncharacterized Tissue Antibodies  >2 publications with OSM and Uncharacterized Tissue
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