Mouse Anti-MMP-7 Monoclonal Antibody – Cat# MBS690216

MMP-7 Antibody – Mouse Monoclonal

Name: MMP-7 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS690216
Price: 875 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS690216

lcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP7 (matrilysin) is expressed in epithelial cells of normal and diseased tissues, and is capable of digesting a large series of proteins of… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

MMP-7, Monoclonal Antibody

Full Product Name

Mouse Anti-Human MMP-7

Product Gene Name

anti-MMP-7 antibody

Product Synonym Names

Anti human MMP-7

Clonality

Monoclonal

Isotype

IgG2

Clone Number

(4C21)

Host

Mouse

Species Reactivity

Human

Form/Format

Lyophilized

Purity/Purification

Protein G affinity chromatography

Specificity

This antibody recognizes human MMP-7 in western blot without cross reactivity with other human MMPs. Reactivity to MMP-7 of other species is not tested.

Preparation and Storage

Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.

Molecular Weight

29,677 Da

Chromosome Location

Chromosome: 11; NC_000011.10 (102520508..102530747, complement). Location: 11q21-q22

OMIM

178990

3D Structure

ModBase 3D Structure for P09237

Antibody Generation

This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with purified human recombinant human MMP-7). The IgG2 fraction of the tissue culture supernatant was purified by Protein G affinity chromatography.

Antigen

recombinant human MMP-7

Reconstitution

Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-MMP-7 antibody

Western Blot (WB), Immunohistochemistry (IHC) - Paraffin

Application Notes for anti-MMP-7 antibody

1. Western blot: Yes (1:500-200). 2. Immunohistochemistry: Yes (1:50-200)

Other Notes

Small volumes of anti-MMP-7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MMP-7 purchase

MBS690216 is an antibody targeting MMP-7. Also known as Mouse Anti-Human MMP-7. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for MMP-7. It may not necessarily be applicable to this product.

NCBI GI #

4505219

NCBI GeneID

4316

NCBI Accession #

NP_002414.1

UniProt Primary Accession #

P09237

UniProt Secondary Accession #

Q9BTK9

UniProt Related Accession #

P09237

GenBank Nucleotide #

NM_002423.3

NCBI Official Full Name

matrilysin preproprotein

NCBI Official Synonym Full Names

matrix metallopeptidase 7 (matrilysin, uterine)

NCBI Official Symbol

MMP7

NCBI Official Synonym Symbols

MMP-7; MPSL1; PUMP-1

UniProt Protein Name

Matrilysin

UniProt Synonym Protein Names

Matrin; Matrix metalloproteinase-7; MMP-7; Pump-1 protease; Uterine metalloproteinase

Protein Family

Matrilysin

UniProt Gene Name

MMP7

UniProt Synonym Gene Names

MPSL1; PUMP1; MMP-7

UniProt Entry Name

MMP7_HUMAN

NCBI Protein Information

matrilysin; matrin; pump-1 protease; uterine matrilysin; uterine metalloproteinase; matrix metalloproteinase-7; matrix metalloproteinase 7 (matrilysin, uterine)

NCBI Summary for MMP-7

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]

UniProt Comments for MMP-7

Function: Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase. Ref.7

Catalytic activity: Cleavage of 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in B chain of insulin. No action on collagen types I, II, IV, V. Cleaves gelatin chain alpha-2(I) > alpha-1(I).

Cofactor: Binds 2 calcium ions per subunit.Binds 2 zinc ions per subunit.

Subcellular location: Secreted › extracellular space › extracellular matrix

Probable.

Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Sequence similarities: Belongs to the peptidase M10A family.

Research Articles on MMP-7

1. Increased expression of MMP7 is associated with colorectal cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MMP-7 antibody

Reference Product	PubMed Publications
MMP1 antibody	>52 publications with MMP-7 and MMP1
CTNNB1 antibody	>47 publications with MMP-7 and CTNNB1
TIMP1 antibody	>29 publications with MMP-7 and TIMP1
CD44 antibody	>19 publications with MMP-7 and CD44
COL18A1 antibody	>3 publications with MMP-7 and COL18A1
SDC1 antibody	>2 publications with MMP-7 and SDC1
HBEGF antibody	>2 publications with MMP-7 and HBEGF
NGF antibody	>1 publications with MMP-7 and NGF

Pathways associated with anti-MMP-7 antibody

Products by Pathway	Pathway Diagram
AGE/RAGE Pathway antibodies	AGE/RAGE Pathway Diagram
Activation Of Matrix Metalloproteinases Pathway antibodies	Activation Of Matrix Metalloproteinases Pathway Diagram
Alpha6-Beta4 Integrin Signaling Pathway antibodies	Alpha6-Beta4 Integrin Signaling Pathway Diagram
Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies	Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
Collagen Degradation Pathway antibodies	Collagen Degradation Pathway Diagram
Collagen Formation Pathway antibodies	Collagen Formation Pathway Diagram
Degradation Of The Extracellular Matrix Pathway antibodies	Degradation Of The Extracellular Matrix Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram
Matrix Metalloproteinases Pathway antibodies	Matrix Metalloproteinases Pathway Diagram
Syndecan-1-mediated Signaling Events Pathway antibodies	Syndecan-1-mediated Signaling Events Pathway Diagram

Diseases associated with anti-MMP-7 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>258 publications with MMP-7 and Neoplasms
Adenocarcinoma Antibodies	>74 publications with MMP-7 and Adenocarcinoma
Neoplasm Metastasis Antibodies	>63 publications with MMP-7 and Neoplasm Metastasis
Lung Diseases Antibodies	>48 publications with MMP-7 and Lung Diseases
Inflammation Antibodies	>45 publications with MMP-7 and Inflammation
Lung Neoplasms Antibodies	>30 publications with MMP-7 and Lung Neoplasms
Fibrosis Antibodies	>28 publications with MMP-7 and Fibrosis
Colonic Neoplasms Antibodies	>27 publications with MMP-7 and Colonic Neoplasms
Breast Neoplasms Antibodies	>26 publications with MMP-7 and Breast Neoplasms
Disease Models, Animal Antibodies	>23 publications with MMP-7 and Disease Models, Animal

Organs/Tissues associated with anti-MMP-7 antibody

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>68 publications with MMP-7 and Lung
Liver Antibodies	>27 publications with MMP-7 and Liver
Intestine Antibodies	>25 publications with MMP-7 and Intestine
Kidney Antibodies	>25 publications with MMP-7 and Kidney
Stomach Antibodies	>20 publications with MMP-7 and Stomach
Brain Antibodies	>17 publications with MMP-7 and Brain
Skin Antibodies	>15 publications with MMP-7 and Skin
Uterus Antibodies	>15 publications with MMP-7 and Uterus
Connective Tissue Antibodies	>14 publications with MMP-7 and Connective Tissue
Prostate Antibodies	>12 publications with MMP-7 and Prostate