Rat Anti-LIMP-II Monoclonal Antibody – Cat# MBS690239

LIMP-II Antibody – Rat Monoclonal

Name: LIMP-II Antibody; Monoclonal; Rat; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS690239
Price: 875 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS690239

Lysosomes are intracytoplasmic organelles that are found within leukocytes (granulocytes, neutrophils, basophils and eosinophils) and function as storage granules for small particles. Lysosomes actively support subcellular protein degradation mechanisms… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

LIMP-II, Monoclonal Antibody

Full Product Name

Rat Anti-Mouse LIMP-II

Product Gene Name

anti-LIMP-II antibody

Product Synonym Names

Scarb2; LGP85; Cd36l2; LIMP-2; MLGP85; 9330185J12Rik

Clonality

Monoclonal

Isotype

IgG1

Clone Number

(1K53)

Host

Rat

Species Reactivity

Mouse

Form/Format

Lyophilized

Preparation and Storage

Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.

Molecular Weight

54,044 Da

Chromosome Location

Chromosome: 5; NC_000071.6 (92443873..92505608, complement). Location: 5; 5 E3

3D Structure

ModBase 3D Structure for O35114

Antibody Generation

This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with mouse recombinant protein of LIMP-II.

Reconstitution

Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-LIMP-II antibody

Western Blot (WB)

Other Notes

Small volumes of anti-LIMP-II antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LIMP-II purchase

MBS690239 is an antibody targeting LIMP-II. Also known as Rat Anti-Mouse LIMP-II. Reactive in Mouse. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for LIMP-II. It may not necessarily be applicable to this product.

NCBI GI #

6680878

NCBI GeneID

12492

NCBI Accession #

NP_031670.1

UniProt Primary Accession #

O35114

UniProt Secondary Accession #

Q3UNF8

UniProt Related Accession #

O35114

GenBank Nucleotide #

NM_007644.3

NCBI Official Full Name

lysosome membrane protein 2

NCBI Official Synonym Full Names

scavenger receptor class B, member 2

NCBI Official Symbol

Scarb2

NCBI Official Synonym Symbols

LGP85; Cd36l2; LIMP-2; MLGP85; 9330185J12Rik

UniProt Protein Name

Lysosome membrane protein 2

UniProt Synonym Protein Names

85 kDa lysosomal membrane sialoglycoprotein; LGP85; Lysosome membrane protein II; LIMP II; Scavenger receptor class B member 2

Protein Family

Lysosome membrane protein

UniProt Gene Name

Scarb2

UniProt Synonym Gene Names

LGP85; LIMP II

UniProt Entry Name

SCRB2_MOUSE

NCBI Protein Information

lysosome membrane protein 2; LIMP II; lysosome membrane protein II; 85 kDa lysosomal membrane sialoglycoprotein; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2

NCBI Summary for LIMP-II

This gene encodes a CD36-like type III transmembrane glycoprotein that localizes to the lysosomal membrane. Mice lacking the encoded protein exhibit an increased postnatal mortality caused by an obstruction of the ureteropelvic junction, deafness, peripheral demyelinating neuropathy and tubular proteinuria. [provided by RefSeq, Aug 2015]

UniProt Comments for LIMP-II

Function: Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting.

Subunit structure: Interacts with GBA.

Subcellular location: Lysosome membrane; Multi-pass membrane protein.

Tissue specificity: Detected in the extracts of brain, heart, lung, liver and kidney.

Post-translational modification: Acylated by palmitic acid group(s)

By similarity.Heavily glycosylated.

Sequence similarities: Belongs to the CD36 family.

Research Articles on LIMP-II

1. Limp-2 deficiency leads to a minor increase in circulating renin. Limp-2, however, is not required for acute or chronic stimulation of renin release.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-LIMP-II antibody

Products by Pathway	Pathway Diagram
Lysosome Pathway antibodies	Lysosome Pathway Diagram
Lysosome Pathway antibodies	Lysosome Pathway Diagram

Diseases associated with anti-LIMP-II antibody

Disease Name	Pubmed Publications
EPILEPSY, PROGRESSIVE MYOCLONIC 4, WITH OR WITHOUT RENAL FAILURE Antibodies	>180966 publications with LIMP-II and EPILEPSY, PROGRESSIVE MYOCLONIC 4, WITH OR WITHOUT RENAL FAILURE
Neoplasms Antibodies	>13 publications with LIMP-II and Neoplasms
Kidney Diseases Antibodies	>9 publications with LIMP-II and Kidney Diseases
Disease Models, Animal Antibodies	>6 publications with LIMP-II and Disease Models, Animal
Cardiovascular Diseases Antibodies	>6 publications with LIMP-II and Cardiovascular Diseases
Adenocarcinoma Antibodies	>5 publications with LIMP-II and Adenocarcinoma
Liver Neoplasms Antibodies	>5 publications with LIMP-II and Liver Neoplasms
Inflammation Antibodies	>4 publications with LIMP-II and Inflammation
Carcinoma, Hepatocellular Antibodies	>4 publications with LIMP-II and Carcinoma, Hepatocellular
Arteriosclerosis Antibodies	>4 publications with LIMP-II and Arteriosclerosis

Organs/Tissues associated with anti-LIMP-II antibody

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>12 publications with LIMP-II and Kidney
Liver Antibodies	>11 publications with LIMP-II and Liver
Brain Antibodies	>7 publications with LIMP-II and Brain
Muscle Antibodies	>6 publications with LIMP-II and Muscle
Skin Antibodies	>4 publications with LIMP-II and Skin
Ovary Antibodies	>4 publications with LIMP-II and Ovary
Lung Antibodies	>4 publications with LIMP-II and Lung
Spinal Cord Antibodies	>4 publications with LIMP-II and Spinal Cord
Heart Antibodies	>4 publications with LIMP-II and Heart
Spleen Antibodies	>2 publications with LIMP-II and Spleen