Rat Anti-TIM-1 Monoclonal Antibody – Cat# MBS690254

T-Cell Immunoglobulin Mucin-1 (TIM-1) Antibody – Rat Monoclonal

Name: TIM-1 Antibody; Monoclonal; Rat; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS690254
Price: 875 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS690254

MUC-1 (Mucin-1; also PEM, PEMT, Episialin, tumor-associated mucin, and carcinoma associated mucin) is a 240-450 kDa type I transmembrane glycoprotein. Human MUC-1 is 1255 amino acids (aa) in length and contains a 23 aa signal sequence, a 1135 aa extracellular… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

T-cell Immunoglobulin Mucin-1 (TIM-1), Monoclonal Antibody

Full Product Name

Rat Anti-Mouse T-cell Immunoglobulin Mucin-1 (TIM-1)

Product Gene Name

anti-TIM-1 antibody

Product Synonym Names

Anti-mouse TIM-1 [T-cell Immunoglobulin Mucin-1] (#3F22)

Clonality

Monoclonal

Isotype

IgG2

Clone Number

(3F22)

Host

Rat

Species Reactivity

Mouse

Form/Format

The IgG fraction of culture supernatant was purified by Protein A/G affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS). Lyophilized samples are stable for 2 years from date of receipt when stored at

Purity/Purification

Protein A/G affinity chromatography

Specificity

This antibody detects mouse of TIM-1 in Western blotting. This antibody does not cross-react with mouse TIM-2 and TIM-3.

Preparation and Storage

Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.

Molecular Weight

33,361 Da

Chromosome Location

Chromosome: 11; NC_000077.6 (46739822..46779578). Location: 11 B1.1; 11

3D Structure

ModBase 3D Structure for Q5QNS5

Antibody Generation

This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with purified mouse recombinant TIM-1. The IgG2 fraction of the culture supernatant was purified by Protein A/G affinity chromatography.

Reconstitution

Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-TIM-1 antibody

Western Blot (WB)

Application Notes for anti-TIM-1 antibody

1. Western blotting: Yes (1:500-1000)

Other Notes

Small volumes of anti-TIM-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TIM-1 purchase

MBS690254 is an antibody targeting TIM-1. Also known as Rat Anti-Mouse T-cell Immunoglobulin Mucin-1 (TIM-1). Reactive in Mouse. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for TIM-1. It may not necessarily be applicable to this product.

NCBI GI #

262231823

NCBI GeneID

171283

NCBI Accession #

NP_001160103.1

UniProt Primary Accession #

Q5QNS5

UniProt Secondary Accession #

Q7TPU2; Q8VIM1; Q8VIM2

UniProt Related Accession #

Q5QNS5

GenBank Nucleotide #

NM_001166631.1

NCBI Official Full Name

hepatitis A virus cellular receptor 1 homolog isoform b

NCBI Official Synonym Full Names

hepatitis A virus cellular receptor 1

NCBI Official Symbol

Havcr1

NCBI Official Synonym Symbols

Tim1; KIM-1; TIM-1; Timd1; AI503787

UniProt Protein Name

Hepatitis A virus cellular receptor 1 homolog

UniProt Synonym Protein Names

Kidney injury molecule 1; KIM-1; T cell immunoglobulin and mucin domain-containing protein 1; TIMD-1; T cell membrane protein 1; T-cell immunoglobulin mucin receptor 1

Protein Family

Protein timeless

UniProt Gene Name

Havcr1

UniProt Synonym Gene Names

Kim1; Tim1; Timd1; HAVcr-1; KIM-1; TIMD-1; TIM-1

UniProt Entry Name

HAVR1_MOUSE

NCBI Protein Information

hepatitis A virus cellular receptor 1 homolog; TIMD-1; HAVcr-1; kidney injury molecule 1; t cell membrane protein 1; T-cell immunoglobulin mucin receptor 1; T-cell immunoglobulin and mucin domain containing 1; t cell immunoglobulin and mucin domain-containing protein 1

UniProt Comments for TIM-1

Function: May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4. May play a role in kidney injury and repair

By similarity. Ref.4

Subcellular location: Membrane; Single-pass type I membrane protein

Probable.

Tissue specificity: Expressed by stimulated T-cells. Expressed during primary antigen stimulation. Ref.1

Polymorphism: Highly polymorphic. Depending on the alleles, expression is associated with an increase and early (BALB/c allele) or decrease (HBA allele) of T-helper type 2 cytokine expression. Associated with asthma susceptibility.

Miscellaneous: Belongs to the T-cell and airway phenotype regulator (Tapr) locus, a single chromosomal region that confers reduced T-helper type 2 responsiveness and protects against airway hyperactivity (AHR), the hallmark of human asthma.

Sequence similarities: Belongs to the immunoglobulin superfamily. TIM family.Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Research Articles on TIM-1

1. Sustained KIM-1 expression promotes kidney fibrosis and provides a link between acute and recurrent injury with progressive chronic kidney disease.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-TIM-1 antibody

Disease Name	Pubmed Publications
Kidney Diseases Antibodies	>174 publications with TIM-1 and Kidney Diseases
Acute Kidney Injury Antibodies	>137 publications with TIM-1 and Acute Kidney Injury
Renal Insufficiency Antibodies	>95 publications with TIM-1 and Renal Insufficiency
Inflammation Antibodies	>38 publications with TIM-1 and Inflammation
Proteinuria Antibodies	>37 publications with TIM-1 and Proteinuria
Cardiovascular Diseases Antibodies	>35 publications with TIM-1 and Cardiovascular Diseases
Lung Diseases Antibodies	>31 publications with TIM-1 and Lung Diseases
Necrosis Antibodies	>26 publications with TIM-1 and Necrosis
Disease Models, Animal Antibodies	>24 publications with TIM-1 and Disease Models, Animal
Liver Diseases Antibodies	>20 publications with TIM-1 and Liver Diseases

Organs/Tissues associated with anti-TIM-1 antibody

Organ/Tissue Name	Pubmed Publications
Other Antibodies	>49 publications with TIM-1 and Other
Lymph Node Antibodies	>3 publications with TIM-1 and Lymph Node