B7-H2 Antibody – Mouse Monoclonal

Cathepsins of the papain family can be divided into two functional groups. One group comprises ubiquitously expressed, intracellular housekeeping proteases responsible for the general lysosomal protein breakdown. The cathepsins L, B, H, and probably O (1, 2) belong to this group. The other group is characterized by a tissue restricted expression pattern and by the assignment of specific functions correlated with their tissue distribution. For example, cathepsin S, the first known tissue-specific cysteine protease is primarily expressed in lymphatic tissues (3,4) and is responsible for the specific degradation of the invariant chain of MHC class II complexes in antigen-presenting cells (5, 6). Cathepsin K, which is predominantly expressed in osteoclasts, is a major protease in bone resorption (7-9). All presently known thiol-dependent cathepsins share common protein structures with a signal sequence of 16 -18 amino acids, followed by a propeptide of 62 -100 residues and then a catalytically active mature region of about 220 -230 amino acids (1). The propart is involved in the folding of the precursor protein, in the temporary inhibition of the protease in its precursor form, and in transport of the proenzyme to the endosomal/lysosomal compartment using mannose 6-phosphateN-glycosylation sites (10,11). Finally, the mature, catalytically active, enzyme contains the catalytic triad consisting of Cys-25, His-159, and Asn-175 (papain numbering) and is folded into a two-domain structure. In addition, thiol-dependent cathepsins have been characterized as lysosomal enzymes, since they have signal sequences and potential N-glycosylation sites and generally have pH optima in the acidic pH range.

Small volumes of anti-B7-H2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS690255 is an antibody targeting B7-H2. Also known as Mouse Anti-Human B7-H2. Reactive in Human. Host: Mouse.