EPHRIN-A3 Antibody – Mouse Monoclonal

EphrinA3, also known as Ehk1L, EFL2, and LERK3, is a member of the ephrin ligand family which binds members of the Eph receptor family. All ligands share a conserved extracellular sequence, which most likely corresponds to the receptor binding domain. This conserved sequence consists of approximately 125 amino acids and includes four invariant cysteines. The Aclass ligands have a GPI anchor following the conserved sequence. EphrinA3 has been shown to bind EphA2, EphA3, EphA4, EphA5, EphA6, EphA7, EphA8, and EphB1. The extracellular domains of human and mouse EphrinA3 share 96% amino acid identity. Only membrane-bound or Fc-clustered ligands are capable of activating the receptor in vitro. While soluble monomeric ligands bind the receptor, they do not induce receptor autophosphorylation and activation. In vivo, the ligands and receptors display reciprocal expression. It has been found that nearly all receptors and ligands are expressed in developing and adult neural tissue. The Eph/ephrin families also appear to play a role in angiogenesis.

Small volumes of anti-Ephrin-A3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS690264 is an antibody targeting Ephrin-A3. Also known as Mouse Anti-Human Ephrin-A3. Reactive in Human. Host: Mouse.